Treatment of chronic mycotic prostatitis. Treatment of prostatitis with bacteriophages Is it possible to treat bacterial prostatitis with bacteriophages reviews

M. Kameneva

Cand. biol. Sci., Senior Microbiologist, Department of Diphtheria Toxoids and Bacteriophages, NPO "Biomed"

What medicine should be preferred if the cause of the disease is a pathogenic microflora? In any pharmacy you will be offered a wide range of antibiotics, but sometimes not only patients, but even pharmacists and doctors do not know about bacteriophages. And this is understandable. Throughout their history, bacteriophages have experienced a general interest in them in the era of their inception, and almost complete oblivion in the 60-80s. However, in the last 5 years, interest in them has revived.

Both antibiotics and bacteriophages act directly on microbes, only antibiotics destroy not only pathogenic, but also normal microflora, disturbing the natural balance, while bacteriophages act only on pathogenic microorganisms. Such selective action is due to their nature. Bacteriophages are viruses of bacteria. When meeting a sensitive microbial cell, the phage penetrates inside it, switches its mechanism of action to reproduce its own kind, which, breaking the cell membrane, attack other microbes tenfold. Lysis becomes spontaneous, and the release of unwanted microbes occurs in a matter of hours.

Phagolysis - the destruction of bacteria by phages - is a natural process that occurs in an organ affected by bacteria during spontaneous recovery. And if, for some reason, self-healing does not occur, the body can be helped by introducing the appropriate bacteriophage obtained under production conditions. The phage is named after the microbe it acts on. Salmonella, typhoid, dysentery, staphylococcal, Klebsiella, Pseudomonas aeruginosa, Proteus, coli, streptococcal - this is an incomplete list of phages currently produced by domestic enterprises. We should also mention complex preparations, which are a set of phages for several pathogens at once: this is a pyobacteriophage for the treatment of purulent-septic diseases and an intestibacteriophage against intestinal infections. The main producers of bacteriophages in our country are NPO Immunopreparat (Ufa), an enterprise for the production of bacterial preparations (Nizhny Novgorod), MP Biofon (Saratov), ​​NPO Biomed (Perm).

Clinical practice has shown the effectiveness of the use of bacteriophages in infectious diseases gastrointestinal tract, as well as in inflammatory diseases of the sinuses, oral cavity, upper respiratory tract, genitourinary system, cholecystitis, etc., caused by bacteria sensitive to phage.

However, phages, these ""natural orderlies"", can be used not only for treatment, but also for prevention. infectious diseases. They are non-toxic, have no contraindications for use, and can be used in combination with any other drugs. They can be prescribed to pregnant women, nursing mothers and children of any age, including premature babies. The main condition for their successful application is to test the isolated culture for sensitivity to the corresponding phage. An amazing regularity was noted: unlike antibiotics, the sensitivity of clinical strains of microorganisms to bacteriophages is stable and tends to increase, which can be explained by the enrichment of medicinal preparations with new races of phages.

Staphylococcal bacteriophage today lyses over 90% of staphylococci isolated from purulent-inflammatory diseases. In addition to medical applications, bacteriophages are widely used in veterinary medicine; especially effective staphylococcal bacteriophage in the treatment of mastitis in cows. Bacteriophage preparations are prescribed orally for diseases internal organs or locally, directly on the lesion. The action of the phage is manifested already 2-4 hours after its introduction (which is especially important in intensive care). Bacteriophages penetrate into the blood, lymph and are excreted through the kidneys, sanitizing the urinary tract.

The activity of a bacteriophage is expressed by the degree of its dilution, at which complete lysis of a sensitive test culture occurs. For example, a titer of 10-6 means that the phage exhibits its lytic effect when diluted 1,000,000 times. Liquid phage preparations retain their activity from 6 to 12 years at a temperature of (6–4) 0 C in a place protected from light.

More than 100 years have passed since the first mention of phages, even before their official discovery by d "Erel in 1917. In 1896, Hankin, trying to explain the strong antibacterial effect of the waters of the Ganges and Jumna rivers in India, first described an agent that passes through bacterial filters and causes lysis of microbes, but is destroyed by boiling. Subsequently, d "Erel gave him the name bacteriophage? "eater of bacteria" The first report of successful phage therapy known to science was made in 1921 by Brijong and Maisin, who used a staphylococcal bacteriophage to treat contagious skin diseases. In the 1920s, phages were actively used in the treatment various diseases. However, in the 1940s they were supplanted by antibiotics, and in the West they were completely forgotten about phages.

Today at Western countries interest in phages has been reawakened. The impetus for this was the growing number of antibiotic-resistant microorganisms, especially staphylococci and Pseudomonas aeruginosa. Moreover, not only specialists are interested in bacteriophages, but even politicians. US Vice President Al Gore called phages "a new weapon to fight pathogenic bacteria." AT last years defended a number of doctoral dissertations on practical application bacteriophages, for example, in Finland - on the inclusion of the latter in yoghurts. Several American firms began to produce phages.

Looking at the scale with which the production of phages in the West is beginning to improve, one can confidently predict that in ten years their production will become one of the leading industries in the pharmaceutical industry.

It is possible and vital to treat bacterial flora with phages in gynecology and urology, about this in the article

"Review on the treatment with phages of bacterial vaginosis and prostatitis of a married couple from the Crimea." Atopopobium of the vagina goes away, the normal microflora is restored , andno antibiotics, about this also in the article "Review on the treatment with phages of bacterial vaginosis and prostatitis of a married couple from the Crimea."

Misuse antibiotic ov led to the fact that they are more do not treat the human body from opportunistic and pathogenic flora. Microbes are immortal, but man is not doomed!

There is an alternative in treatment, and these are bacteriophages -

bacterial viruses consisting of one or two nucleic acid chains. Most often, they multiply in bacterial cells and cause their decay. Bacteriophages - a well-forgotten old. This year marks exactly 100 years since they were discovered by the Canadian microbiologist Felix D'Herrel.

As an example of the effectiveness of the use of bacteriophages in the treatment of bacterial vaginosis and prostatitis, I cite as an example a letter of review from a married couple from the Crimea.

“Good afternoon Tatyana Robertovna and readers of this site. We would like to leave our feedback about our problem and the treatment that Tatyana Robertovna prescribed to us. We both had complaints of itching, burning, pain in the genitourinary system. I took a lot of courses of antibiotics. Courses of antibiotics helped, but then two months later, all the symptoms returned. For a year, my wife took such courses 6 times, which they didn’t drink or inject. The whole pharmacy went through us. After four courses, my wife found ATOPOBIUM VAGINAE, I constantly have one or the other UPF. Treatment with antibiotics did not solve the problem. We accidentally found this site, read it and we liked Tatyana Robertovna's approach to treatment and understanding the problem of fighting unnecessary bacteria. Antibiotics no longer believed in them. We wrote a letter to Tatyana Robertovna, she immediately responded to our problem and scheduled us to undergo tests. Then we got treatment. Treatment is long, from a month - but without side effects and persecution of organisms. They even lost weight (who needs it :), because. you need to follow a diet during treatment. After the main stage, they passed the tests and, lo and behold, my wife does not have ATOPOBIUM VAGINAE, and I began to feel much better. Now we are going through a corrective course. We would like to say a BIG THANK YOU to Tatiana Robertovna for your professionalism and for helping people. May God bless you with health, well-being, love and success in life. Sincerely, Andrey and Natalya.”

For many, this is food for thought. And for some, who are growing in number, it is a consciously chosen alternative method of treatment.

bacterial flora.

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Normally, the prostate gland does not contain foreign microorganisms. Sometimes bacteria through the urinary tract or through the blood can enter the prostate and cause inflammation. This is how acute and chronic bacterial prostatitis. For a man, this is an extremely unpleasant and painful experience.

Causes of bacterial prostatitis

Bacterial prostatitis can be caused by 2 reasons - these are pathogenic and conditionally pathogenic microorganisms.

• Pathogenic bacteria include sexually transmitted infections such as chlamydia and gonococci. Persons leading a disorderly sexual life, lead the risk group for specific prostatitis.
• Among nonspecific microorganisms in men over 35 years of age, prostatitis is most often caused by Escherichia coli. Usually the infectious process begins in the urethra and then ascends to the prostate. About 25-40% of the population are carriers of pathogenic staphylococci.

Staphylococcus colonizes the epidermis, where it may not show its presence for a long time. When it enters the skin wounds or damaged mucous membranes, the microorganism begins to show its pathogenic properties. Staphylococcus aureus in the prostate is often the cause of bacterial prostatitis.

Other opportunistic bacteria that cause prostatitis:

• staphylococcus hemolytic;
• Pseudomonas aeruginosa;
• klebsiella;
• Proteus;
• enterobacter;
• epidermal staphylococcus aureus.

With timely antibiotic treatment, in most cases, recovery occurs. It should be understood that a key factor in the development of nonspecific bacterial prostatitis is a decrease in immunity. In order to avoid relapses of the disease, it is necessary to strengthen the body's defenses.

Symptoms of bacterial prostatitis

With bacterial prostatitis, the clinical manifestations of the disease begin quickly. The patient may be disturbed by the general symptoms of inflammation in the body: chills, fever, redness of the skin.

In addition, there are local symptoms:

• blood in urine
• burning and pain when urinating
• weak urine stream
• difficulty emptying the bladder
• pain and burning in the lower abdomen, lumbar and sacral region of the back, in the perineum or testicles;
• pain during bowel movements and ejaculation;
• the presence of blood in the semen.

Diagnosis of the disease

Usually, the diagnosis of this disease is not difficult.

On examination, the doctor may find enlargement or tenderness of the lymph nodes in the groin. It is possible to detect fluid released from the urethra, swelling and tenderness of the scrotum. With a digital examination of the prostate, its enlargement is determined. With a chronic infection of the prostate gland, it will be felt softening. Palpation reveals a sharply painful, swollen, soft and warm prostate gland.

In a laboratory examination, signs of bacterial prostatitis will be noted in the urine: leukocytosis, the presence of bacteria is possible. Bacteriological analysis of urine will allow you to isolate the pathogen and determine it with prostatitis. possible increase in the level of leukocytes and erythrocyte sedimentation rate.

Treatment of bacterial prostatitis

Can bacterial prostatitis be cured? Treatment can and should be done. Timely appeal to the urologist will allow this disease.

Traditionally, antibiotics and anti-inflammatory therapy are used to treat bacterial prostatitis. The optimal treatment regimen includes the appointment of an antibiotic after determining the sensitivity of the pathogen. Prior to this, drugs for the treatment of prostatitis are selected empirically. Most often, drugs of the fluoroquinolone series are taken. These antibiotics have good tissue penetration and a wide spectrum of antimicrobial activity, including causative agents of bacterial prostatitis. Antibiotics in the treatment of acute prostatitis take 2-4 weeks.

Treatment of chronic bacterial prostatitis requires longer therapy. Antibiotics in this case are selected after determining the pathogen and its sensitivity to the drug. To achieve a therapeutic effect, combination therapy is required, which includes measures aimed at increasing immunity. Physiotherapeutic procedures are prescribed - electrophoresis, magnetotherapy, laser therapy, prostate massage.

Antibiotics have their drawbacks. One of them is dysbacteriosis. You can use an alternative treatment - bacteriophages. They do not have such a negative effect, which makes their use attractive. By nature, bacteriophage is an antimicrobial virus. It is selectively introduced into the pathogen. The bactericidal effect is manifested in the fact that multiplying inside the cell, phages cause the death of the microbe. Another advantage is that bacteriophage can prescribe in the presence of antibiotic-resistant bacteria.

Bacteriophages act more selectively than antibiotics. Therefore, treatment with phages requires mandatory identification of the pathogen. For example, a staphylococcal bacteriophage kills only staphylococci, and will not act on other pathogens. The treatment regimen for bacterial prostatitis with phages lasts 7-10 days. Bacteriophage for prostatitis is applied orally and topically as irrigations and lavages.

Sometimes bacterial swelling of the prostate gland makes it difficult to empty the bladder. In such cases, the installation of a urinary catheter is required. It can be placed through the abdomen (suprapubic catheter) or inside the urethra (urethral catheter).
The patient should take a large number of liquid, about 2-4 liters. The flow of urine will help flush out microorganisms from the urethra and prostate.

With prostatitis, hot and spicy food is worth it.

Do not self-medicate! Do not treat prostatitis folk remedies! The decision on how to treat bacterial prostatitis and which antibiotics to use should be made by the doctor, as each case is unique.

Possible Complications

Untreated prostatitis threatens with a large number of complications.

• One of the complications of acute bacterial prostatitis is its transition to chronic bacterial prostatitis. This disease is complex and difficult to treat. can lead to infertility.
• With inadequate treatment, small pustules appear in the prostate tissue, which merge, and one large abscess is formed - an abscess of the prostate gland. This complication will require surgical treatment.
• If the swelling of the gland during inflammation is very pronounced, urinary retention may develop. This condition is dangerous because it can lead to rupture of the bladder or urethra. The ingress of urine and micro-organisms into abdominal cavity lead to peritonitis, which can cause sad consequences.
• If bacteria manage to get from the prostate into the bloodstream, such a formidable complication as sepsis will develop. Treatment methods for this condition require long-term hospitalization in the intensive care unit, a combination of surgical debridement of infection foci and multicomponent general therapy.
• With purulent fusion of the prostate, the formation of fistulas with neighboring organs is possible. Treatment of such complications is very long and requires the intervention of a surgeon.

A complication of bacterial prostatitis is possible in every patient. Therefore, at the first signs of the disease, you should immediately consult a doctor.

Prevention of bacterial prostatitis

Although bacterial prostatitis can be cured, it is best to prevent it from occurring.

To prevent the occurrence of bacterial prostatitis, it is important to practice safe sexual behavior. Having a regular sex life with one regular partner is the best defense against prostatitis.

Lessons physical culture, giving up bad habits and balanced diet help maintain immunity at a sufficiently high level, which is also an important aspect in the prevention of bacterial prostatitis.

Infections of the genitourinary system, including prostatitis, tend to have a long and protracted course, and in half of the cases become chronic. Despite all the pharmacological possibilities of modern medicine, the effectiveness of their therapy undergoes some difficulties and does not allow to completely get rid of the causative agent of the disease. This requires the search for additional solutions to the problem, one of which is the treatment of prostatitis with bacteriophages.

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Indication for admission

Prostatitis is infectious inflammatory process prostate tissue caused by various bacterial agents. It is extremely important to determine the specific type of pathogen for further drug selection. Indications for the appointment of bacteriophages in patients with this pathology are as follows:

• confirmed laboratory-bacterial nature of the disease;
• chronic variant of the course of prostatitis;
• ineffectiveness of treatment with a course of antibiotics;
• isolation of a culture of resistant (resistant to the main treatment) bacteria;
• the presence of temporary contraindications to the appointment of antibiotics (for example, severe intestinal dysbacteriosis, the presence of allergic reaction, severe immune disorders);
• complications of prostatitis;
• concomitant infectious processes of other organs and systems;
• as a component of combination therapy;
• advanced or senile age, diseases accompanied by a decrease in the body's defenses;
• in young children;
• additional prevention of recurrence or exacerbation of chronic prostatitis.

Contraindications

There are no contraindications to the use of bacteriophages in prostatitis. The only exception is individual intolerance or sensitivity to any of the components of the drug by the patient.

A possible limitation of the dose and frequency of administration is required in patients with severe hepatic or renal insufficiency, since there is a high probability of impaired excretion of the substance from the body. In each case, the decision is made only by the doctor on an individual basis and after interpreting the relevant examination.

Benefits of bacteriophage treatment

bacteriophages

The main advantage of bacteriophages is the specificity of their action against a particular pathogenic bacterial agent. Moreover, there are also phage species that destroy certain variants within the species. In addition, combined polyvalent preparations are produced that can act on several pathogens at the same time, i.e. with a broad antibacterial effect.

Phage therapy is able to destroy bacteria resistant to antibiotics (including II-III generation cephalosporins, fluoroquinolones, which are often prescribed for urinary tract infections). In other cases, they are used even to minimize the use of antibacterial drugs and thus prevent the development of resistance. It is noted that the sensitivity of the pathogenic flora to the phage does not decrease and may even improve. The mechanism of this phenomenon has not yet been studied.

Bacteriophages are a group of viruses that have a negative effect on bacterial agents through lytic enzymes. Phages penetrate the cell, begin to multiply actively and destroy the cell wall. They act exclusively on pathogenic flora. This ensures the safety of the use of phages in relation to the preservation of normal intestinal microflora, in contrast to antibacterial drugs that cause dysbacteriosis.

The onset of action in bacteriophages is very rapid. Literally on the 2-3rd day evaluate the effectiveness. The general condition and well-being improves, body temperature decreases, painful symptoms, dysuric disorders, irritation associated with prostatitis gradually decrease, and quality of life indicators improve. Phages quickly penetrate into the blood and lymph, and are excreted from the human body to a greater extent through the kidneys, thereby additionally sanitizing the urinary tract. When compared with the effect of antibiotic treatment, bacteriophage therapy showed high clinical results and practically comparable data. The development of relapses in the future also has the same frequency in both groups of patients. In addition, high safety, easier tolerance makes bacteriophages an alternative choice of treatment for the elderly, with concomitant immunodeficiency conditions, children, etc.

Action of bacteriophages

In the presence of a bacterial agent that is sensitive to bacteriophage, the number of the latter begins to progressively increase, which can lead to a decrease in the dosage taken. The period of the phage in the blood is also lengthened. None of the known antibiotics has such abilities.

Bacteriophages do not have any toxic effects on the body of a man. They act simultaneously on other chronic foci of infection, even if they are asymptomatic.

The use of bacteriophages in the treatment of any form of prostatitis can cause a positive effect in terms of improving antitoxic, cellular and humoral immunity. Other favorable properties of phages have also been found. For example, the normalization of the exchange of iron and copper. In addition, bacteriophage therapy causes activation and triggers the antioxidant mechanism.

Another important advantage of bacteriophages over the rest pharmacological agents is their relative availability and low material costs required for their acquisition.

Varieties of funds

Prostatitis in men can be caused various types bacteria. Depending on this, there are several main types of bacteriophages that are able to treat this disease:

• Klebsiella (active against Klebsiella);
• coliproteic (bactericidal effect is directed against Escherichia coli, Proteus);
• staphylococcal (high sensitivity in staphylococci);
• Pseudomonas aeruginosa;
• streptococcal;
• combined;
• pyobacteriophage;
• sextaphage;
• intesti-bacteriophage.

Basic principles of therapy

The main condition effective reception bacteriophages is a preliminary determination of the sensitivity of the isolated bacterial culture to the corresponding phage. To do this, it is advisable to examine the secret of the prostate gland in the bacteriological laboratory, in which pathogenic microorganisms (enterobacteria, staphylococci, Pseudomonas aeruginosa, streptococci, etc.) are identified. Less than half of the cases show mixed flora.

As a rule, bacteriophages for the treatment of prostatitis are used in liquid form (vials with solutions). They can be used orally, or used as a local therapy (washing, irrigation, lotions). The daily dose when taken orally is 100 ml. and is divided into 3 stages. Use the medicine strictly on an empty stomach. Locally, the phage solution is passed through the drainage into the lower urinary tract, the bladder, 50 ml 2-3 times a day. Duration of therapy - 10-14 days or more (on average - up to 20). This is necessary to achieve complete penetration of the agent into the prostate tissue. The disadvantage of the mode of using bacteriophages is the need for a daily 3-fold intake compared to 1-fold administration of fluoroquinolones. This fact can negatively affect the patient's adherence to the regular intake of the therapeutic drug.

The duration of therapy for a sluggish form of prostatitis is extended to 1-2 months, with periodic breaks between courses and repeated bacteriological studies of the prostate secretion in the laboratory.

It also provides for the possibility of delivering a bacteriophage to an infectious focus in the prostate tissue in the form of rectal suppositories, microclysters. For this purpose, more suitable combinations of phages acting on several pathogens at once. Candles are applied 2 times a day, morning and evening, for 12-14 days. For microclysters, 50 ml of the medicinal substance is used in the form of a ready-made solution, which is administered after bowel movements also twice a day for 7-10 days. Manipulation makes sense when isolating a population of bacteria introduced from the gastrointestinal tract (Enterococcus fecalis, Escherichia coli).

Gel forms are known, which include one or more bacteriophages, and which are applied externally, 2 times a day after hygienic manipulations.

The degree of activity of the agent is determined by its dilution, at which the wall of bacteria is destroyed. Thus, a titer value of 10 6 corresponds to the fact that the bacteriophage begins to act when diluted 1,000,000 times.

Sometimes, at the discretion of the doctor, bacteriophages can be added to the main antibiotic therapy or prescribed as a course immediately after it. Local treatment with phages is applicable only in combination with oral administration or with the main group of antibiotics (a representative of fluoroquinolones, doxycycline, cephalosporin), since it alone will not lead to complete eradication of the infectious agent. Phage therapy is perfectly combined with any groups of drugs, does not affect their pharmacodynamics and pharmacokinetics, while maintaining biological efficiency.

Are there side effects

Side effects as a result of the use of bacteriophages are not observed. The only adverse reactions may be allergic manifestations, in the form of rashes, urticaria, Quincke's edema, anaphylaxis, etc. In rare cases, dyspeptic disorders (nausea), discomfort in the stomach, mostly acquiring mild or moderate severity, are possible.

There are no data on cases of overdose of bacteriophages.

Among the methods presented by the possibilities of modern medicine, bacteriophages are the most gentle and at the same time safe, highly effective way to treat inflammatory and infectious processes in the prostate gland (prostatitis). In conditions of increasing resistance of pathogenic microflora to last generations antibiotics, this species medicines is becoming almost indispensable in the clinical practice of any medical specialist. In addition, the safe use of phages ensures their wide use in all categories of patients, incl. debilitated and with comorbidities.

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15.02.2018

Prostatitis is an inflammatory disease that affects the prostate - the male reproductive organ, which performs a secretory function and regulates potency. In case of violation of his work, the representative of the stronger sex can become impotent or infertile. The causes of the disease are:

• Inactive lifestyle
• Prolonged sexual abstinence or too frequent sexual intercourse, interruption of sex
• Bad habits, unhealthy diet
• Infection

What is a bacteriophage?

Bacteriophages are found in almost any environment around us, some are already present in the human body, others are in the air, water, soil, food.

Weak potency, a flaccid penis, the absence of a long-term erection is not a sentence for a man's sexual life, but a signal that the body needs help and male strength is weakening. There are a large number of drugs that help a man get a stable erection for sex, but they all have their drawbacks and contraindications, especially if the man is already 30-40 years old. Drops "M16" for potency help not only to get an erection HERE AND NOW, but act as a prevention and accumulation of male power, allowing a man to remain sexually active for many years!...

Therefore, in one patient it may be effective, while in another it may not. But with the simultaneous use of antibiotics and bacteriophages, one can expect an increase in the effectiveness of both.

Indications for use

1. Pathologies of the gastrointestinal tract (cholecystitis, dysbacteriosis)
2. Inflammatory phenomena in newborns or young children
3. Infections after surgery
4. Eye infections
5. Infection prevention in the hospital

Description of medicines

To eliminate inflammation of the prostate gland, bacteriophages of the most different types, after all, various bacteria are capable of causing prostatitis. The choice of medicine occurs only after they have been determined. Consider what medications a doctor can prescribe.

Staphylococcal bacteriophage

Staphylococcal bacteriophage for prostatitis is produced only in the form of a solution, which must be taken orally or used externally. The product is produced in glass ampoules of 20 and 100 ml, in one package there can be 4-10 pieces of the first or 1 pc. second. The main active substance of the drug is a sterile filtrate of phagolysates of Streptococcus strains. Specifically for this medication, indications for admission can be called:

• Diseases of the ENT, respiratory tract, lungs
• Infections that entered the body during surgery
• Urological infections
• Infectious diseases of the digestive tract, dysbacteriosis
• Prevention of pathologies caused by streptococci

The instructions for use say that the solution must be taken orally, rectally or externally. It can also be used to wash the nose or mouth, inject medicine into the vagina, uterus. How to use Bacteriophage for prostatitis: for an adult, it is necessary to use 20-30 ml of the drug daily orally or 40-50 ml during enema. The duration of therapy depends on where the inflammation is located, the course of the disease, and ranges from 1 to 3 weeks.

If it is necessary to use lotions or irrigation, it is necessary to apply up to 200 ml of bacteriophage. With urethritis, the input occurs through drainage, 20-50 ml twice a day. When you need to get to the prostate gland, you can take it inside at the same time (2 times a day before meals) and do an enema (once in the evening).

El Macho for potency

The only contraindication to taking Staphylococcal Bacteriophage is the patient's hypersensitivity to its components. Pay close attention to how the liquid looks, because. when it becomes cloudy, it cannot be used. The bottle with bacteriophages should be shaken before use and look for the presence of sediment (it, like turbidity, is formed by bacteria from environment caught in the wrong use of the vial). Hence a few rules for patients:

1. Wash your hands well before using the product
2. Treat the cap every time with alcohol-containing solutions
3. It is necessary to remove only the cap, and do not touch the inner cork
4. It cannot be placed inside on any surface.
5. Do not leave the bottle open, store only in the refrigerator

Because from the instructions it is clear that the cork cannot be removed, how to draw up the medicine? You need to take a syringe and pierce the stopper with it. When opened, the product can be stored for its entire shelf life, but if the liquid becomes cloudy, get a new one. In a pharmacy, the Bacteriophage of this group is sold without a doctor's prescription.

Intensi bacteriophage

The method of application for the solution is as follows: 30-40 ml orally 1 hour before meals, repeat 4 times a day. The duration of therapy is 7-10 days. When enema, it is necessary to dilute the agent in a small amount of hot water and inject into anus. It is necessary to carry out the procedure 1 time per day, preferably in the evening, before going to bed. After the administration of the drug, the patient needs to lie on his stomach for about 30-40 minutes so that the solution can be absorbed into the tissues.

Before starting the installation of an enema with Intensi-bacteriophage, be sure to empty your intestines - natural way or with a cleansing enema. A combination of both methods is possible. For the prevention of infections, it is necessary to take a single dose of the drug once a day. The cost of one package is about 800 rubles, you can buy it without a prescription from your doctor.

Pyobacteriophage complex

A drug with antibacterial action. Its composition is a mixture of purified filtrates of various bacteria. Phage therapy with it is effective against streptococci, staphylococci and enterococci, Klebsiel pneumonia, etc. Other types of microorganisms medicine It does not work. It is available as a solution for oral or rectal administration.

With the solution, you can make applications and lotions, moisten tampons for vaginal or rectal administration. The exact dosage should be determined by the doctor, based on the patient's condition. Recommended are 30 ml of bacteriophage for internal use and 50 ml for enema. Duration of treatment - from 5 to 15 days. Side effects or cases of overdose with the drug are unknown.

It is necessary to store the bottle with the solution at a temperature of 2 to 8 degrees, the shelf life is 2 years. If a precipitate or cloudiness appears, immediately stop taking it and buy a new package.

Alternative to bacteriophages

The only analogues of bacteriophages can only be antibiotics. They are chosen according to the indicators of sensitivity of bacteria with their active substances, or they stop at broad-spectrum preparations. With prostatitis, 4 groups of antibiotics are used:

• Tetracyclines (Doxycycline, Unidox Solutab). Negatively affect the digestive tract, but are usually well tolerated by patients.
• Penicillins (Amoxicillin, Augmentin). Inexpensive, quite effective, but resistance is quickly developed to them.
• Macrolides (Azithromycin, Fromilid). Penetrates the prostate tissue best of all, has virtually no side effects
• Fluoroquinolones (Levofloxacin, Ofloxin). The most highly effective means, but therefore the most dangerous

Each of them can cope with a certain group of pathogens, as well as reduce the inflammatory process, and facilitate urination. First, doctors may prescribe first-line antibiotics that have a broad list of actions, and after an accurate diagnosis of the infection, prescribe another, with a narrower focus.

Antibiotics have big number side effects, which prevents them from being taken for a long time. In addition, pathogens are able to develop resistance to most of them.

In a pharmacy, you can buy an antibiotic only with a doctor's prescription. He also prescribes a treatment regimen and chooses dosages that may be completely different from those indicated in the instructions.

An interesting opinion of a doctor on the treatment of bacteriophages can be seen below.

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