Inflammation of the prostate gland is a common male disease, and the treatment of prostatitis with bacteriophages is effective for a number of reasons, which will be highlighted in detail in the article. According to statistics, 80% of men experience prostatitis during their lifetime. Moreover, approximately 30% of patients fall into the age category from 20 to 40 years. The prostate is located under the bladder and surrounds the urethra (urethra).
The most dangerous manifestation of prostatitis is the complete inability to urinate.
When does the prostate begin to develop inflammatory process, then the urethra is pinched by the prostate, because due to inflammation, it begins to increase in size. The disease is manifested by difficulty with urination. The disease is curable, but with careless treatment it can turn into chronic form, and in the last stages of development, surgical intervention is often required.
With prostatitis, the patient begins to feel weakness, general performance worsens, body temperature rises. A man has frequent urge to urinate, but the pressure is weak and there is a feeling of pain in the bladder. Additionally, there may be a burning sensation in the perineum, pain in the intestines during bowel movements. If the patient has purulent inflammation, then pieces of pus may come out of the urethra and anus. These are the main symptoms that occur with prostatitis, both acute and chronic.
The most dangerous manifestation of the disease is the complete impossibility of urination. This state requires the patient to be placed in a hospital for the installation of a catheter so that stagnant urine comes out. There are also signs that initially pay little attention and do not associate them with prostatitis, but they may indicate it:
Deterioration of erection for no apparent reason, or even its complete loss; Painful or accelerated ejaculation; Prolonged erection at night during sleep.
If you pay attention to these uncomplicated symptoms in time and contact a specialist, then it will be much easier to cure the disease.
Most often, the inflammatory process in the prostate gland occurs for a number of reasons:
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A WORKING METHOD Sedentary lifestyle or obesity that cause impaired blood circulation in the pelvic area. Infectious lesions that can lead to complications. Often inflammation of the prostate occurs after past illnesses such as: gonorrhea, urethritis, tuberculosis, tonsillitis or influenza. The entry of pathogenic microflora into the prostate through lymph, sexual contact or blood. Staphylococci, streptococci can easily penetrate the prostate gland, and if a man's immunity is weak, then a disease develops. Injuries, hypothermia and physical inactivity can also contribute to the appearance of the disease. Inflammation in the rectum or frequent constipation. Too active sex life.
The main way to treat prostatitis is the use of antibiotic therapy, but it has a number of negative effects that can be avoided if bacteriophages are used.
Due to the fact that most often prostatitis occurs due to a urological infection, which is complicated by the bacterial flora, a certain number of antimicrobial drugs are used in the treatment. Before starting antibiotic treatment, you need to find out exactly which pathogenic microflora provoked the inflammatory process. After identifying the pathogen, an antibiotic is prescribed, but there are times when the antibiotic did not help, and then it is necessary to change the method of treatment.
The essence of bacteriophages is that they destroy the shell of bacteria by introducing a microbe into the cell
There is always a risk of bacteria developing resistance to a particular antibacterial drug, and this method of treatment is also not suitable for people with gastrointestinal diseases. In this case, bacteriophages from prostatitis are used in the treatment. They are good because they do not damage the lining of the stomach, are very effective, are quickly excreted from the body and help, do not cause side effects, and they can also be combined with other medicines, including antibiotics. The essence of bacteriophages is that they destroy the shell of bacteria by introducing a microbe into the cell.
There are certain types of bacteriophage preparations that can affect only one pathogen selectively, so they are administered only after a thorough laboratory test for the causative agent of inflammation. For example, the Klebsiella bacteriophage is aimed at destroying the structural shell of Klebsiella bacteria, the coliproteus phage destroys Escherichia coli and Proteus, the staphylococcal bacteriophage - staphylococcus, aeruginosophage - Pseudomonas aeruginosa.
On average, the course of treatment with these drugs is a week and a half. Depending on laboratory parameters and doctor's prescriptions, treatment can be prescribed either with one specific bacteriophage or in combination with antibiotics. Bacteriophages can be taken as a systemic drug orally and topically to wash and irrigate the problem area.
The first improvements occur after 2-4 days from the start of therapy, and patients also note a general improvement in their condition, normalization of body temperature, pain relief and removal of intoxication. Conclusion - bacteriophages are one of the best ways to get rid of prostatitis by methods of conservative medicine.
Do you have PROSTATITIS? Have you already tried many remedies and nothing helped? These symptoms are familiar to you firsthand:
constant pain in the lower abdomen, scrotum; difficulty urinating; sexual dysfunction.
The only way is surgery? Wait, and don't act radically. Prostatitis is POSSIBLE to cure!
The course of male prostatitis often takes a protracted nature, requiring long-term and complex treatment. Since the main cause of the disease is a urological infection, antibiotic therapy is mandatory in all cases. One of its promising areas is bacteriophages in prostatitis, which have a number of advantages over antibiotics and have good efficiency.
The positive antimicrobial effect of bacteriophages consists in their ability to destroy the membrane of pathogenic bacteria by introducing into the cell body and subsequent intensive reproduction. These drugs have a strict selectivity of action, as they are able to multiply only in a certain type of bacteria. Therefore, the treatment of prostatitis with bacteriophages can be started only when the composition of the pathological microflora is known.
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Unlike antibiotics, to which resistance and resistance develop over time, phage therapy can be prescribed even in cases where the bacteria that caused the disease turned out to be resistant to antibiotic therapy. In addition, this method of treatment has a number of other advantages:
speed of action and deep penetration into the infectious focus; absence negative impact on beneficial intestinal flora; absence side effects and contraindications; rapid elimination from the patient's body; compatibility with other groups of drugs.
Course therapy with phages in this pathology can last from 7 to 10 days. It is possible as an isolated prescription of the drug, and combined, in particular, together with various groups of antibiotics. Bacteriophages for prostatitis are used orally according to the scheme recommended by the attending physician, as well as local therapy, in the form of irrigation and washing.
To date, many varieties of the drug have been synthesized, in particular, from such common infections as staphylococcus aureus, streptococcus, Pseudomonas aeruginosa and many others. Improvement of clinical analyzes occurs as early as 2-4 days, patients also note a decrease in pain and intoxication, dysuric phenomena and normalization of body temperature. One of the conditions for the effectiveness of phage therapy is the preliminary detection of the sensitivity of the microbial flora.
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- Category:
The invention relates to urology and can be used for etiopathogenetic treatment of chronic inflammatory diseases of the prostate. Etiotropic therapy is carried out by introducing a pyobacteriophage, and pathogenetic therapy includes microclysters with electroactivated aqueous solutions of Zn, Mg, Mn salts prepared on the Espero-1 apparatus, and in the first 2 days - with anolyte, and in the next 5-7 days - with the catholyte of these solutions, with the addition of dimexide to them at the rate of 4 ml per 100 ml of solution. The method allows to stop the pain syndrome in short time and improve the effectiveness of treatment. 1 tab.
The invention relates to medicine, in particular to urology, and can be used for the etiopathogenetic treatment of chronic inflammatory diseases of the prostate. Known treatments chronic prostatitis through the complex use of antibacterial drugs, prostate massage, thermal procedures, mud therapy, hormone and immunotherapy (Tkachuk V.I. et al. Chronic prostatitis. - M.: -1989). However, in modern conditions, the microbial flora differs, as a rule, in polyvalent resistance: the achievement of a bacteriostatic concentration of antibiotics and chemotherapy drugs in the prostate tissue is difficult due to the peculiarities of the functioning of its epithelium (Tkachuk V.I. et al. 1989). In addition, prolonged use of antibiotics contributes to the development of candidiasis and diobacteriosis. A known method for the treatment of chronic prostatitis and sexual disorders (USSR author's certificate N486750, A 61 K 17/00) - pathogenetic - by massaging the prostate gland with simultaneous intramuscular administration of proteolytic enzymes. However, this method is aimed at only one link in the pathogenesis - it prevents the development of gross cicatricial deformities and cannot be used independently in the case of an active inflammatory process. There is also known a method for the treatment of chronic urethroprostatitis (author's certificate N 1130345, A 61 H 23/00), based on the introduction of medicinal substances and electrophoresis of antibacterial drugs into the urethral mucosa with modulated currents with the duration of each procedure 5 - 15 minutes. However, this method is invasive, traumatic and painful, although it allows to achieve a significant concentration of drugs in the prostate gland. A known method for the treatment of chronic prostatitis, which allows, according to the authors, to improve regional blood flow and functional activity of the prostate gland due to the impact on the mucous membrane of the rectum in the projection of the prostate gland simultaneously with 2% troxevasin gel and vibration massage against the background of antibacterial therapy (RF patent N 2016563, A 61 H 23/00). This method is closest to what we claim, as it includes etiotropic and pathogenetic therapy, and in this regard, we have adopted as a prototype. In the development of chronic prostatitis, two leading points should be distinguished - etiological and pathogenetic. Impact on only one of them cannot provide not only recovery, but even any long-term remission. The etiological factor is predominantly Proteus vulgaris, E. coli, Staphylococous aurigineus. Pathogenetic factors are a violation of blood and lymph microcirculation, a violation of the outflow of prostate secretion, a deficiency of a number of trace elements (Zn, Mn, Mg) in the prostate tissue. In the method according to the patent of the Russian Federation N 2016563, the effect on the pathogen is carried out by prescribing antibacterial drugs, which is undesirable for a number of the above reasons, such as the predominance of multiresistant flora, insufficient penetration of antibiotics into the prostate parenchyma, and the development of dysbacteriosis. Of the pathogenetic factors, this method allows only to achieve an improvement in blood and lymph microcirculation, and secondarily - an increase in the functional activity of the prostate gland. In addition, electroprocedures included in the medical complex have a number of contraindications. And finally, the application of the method according to the prototype does not affect the content of trace elements in the prostate tissue. Our proposed method is devoid of these disadvantages of the prototype. The aim of the present invention is to increase the effectiveness of the treatment of chronic prostatitis and relieve pain in a short time. This goal is achieved by the fact that etiotropic therapy is carried out by introducing per os a polyvalent bacteriophage (pyobacteriophage), and pathogenetic therapy includes microclysters with electroactivated aqueous solutions of salts Zn, Mn, Mg, and in the first days - with anolyte, and in the following days - with the catholyte of these solutions, with the addition of Dimexide preparation to them at the rate of 4 ml per 100 ml of solution. The use of pyobacteriophage as an etiotropic therapy has the following advantages over traditional antibacterial - antibiotic - therapy: the absence of contraindications and side effects , good tolerability, high efficiency in relation to multiresistant flora, no negative effect on the normal intestinal microflora. At the same time, as a pathogenetic treatment, the patient is given microclysters with electroactivated aqueous solutions of Mg, Mn, Zn, prepared on the Espero-1 apparatus. Carrying out heated to 38 o C microclysters simultaneously promotes hydromassage of the prostate gland and improves blood and lymph microcirculation, namely, they additionally affect 2 more links in the pathogenesis of chronic prostatitis. Dimexide is added to the electroactivated aqueous solution of metal salts at the rate of 4 ml per 100 ml of an aqueous solution - for more targeted delivery of medicinal substances directly to the prostate tissue. Dimexide was chosen by us due to its ability to penetrate well through the skin and mucous membranes, pronounced local anesthetic activity in pain syndromes, its anti-inflammatory and antimicrobial action. The method is carried out as follows. After a complete clinical and laboratory examination, the patient is prescribed pyobacteriophage - 20 ml 4 times a day for the first 5-7 days. At the same time, in the first 2 days, warm (38 o C) microclysters with anolyte are prescribed, and then for 5-7 days - with catholyte of electroactivated solutions of Zn, Mg, Mn salts. The solutions are prepared on a specialized apparatus "Espero-1" in accordance with the instructions attached to it. 4 ml of dimexide are added to 100 ml of an aqueous solution for deeper penetration of drugs into the underlying tissues. Microclysters are carried out in the evening. After the procedure, the patient lies on his stomach for 40-50 minutes. The proposed method of treatment applied by us in 11 patients with chronic prostatitis. In 9 patients (81.8%), a significant improvement was noted, in 2 other patients - an improvement, expressed in the relief of pain and in the sanitation of the secretion of the prostate gland in a short time. In general, the effectiveness of the treatment of chronic prostatitis increased to 81.8%. The table below presents the data of a comparative analysis of the effectiveness of treatment according to the claimed method in comparison with the prototype method. No side effects were noted in any case. Long-term results were followed up for 6-18 months - no relapses of the disease were noted. Example 1. Patient M., aged 33, engineer. D-h: chronic prostatitis with severe pain syndrome. Suffering for 7 years. Repeatedly treated in various clinics, but the effect was incomplete and short-lived. Upon receipt of a complaint of constant dull stabbing pain in the perineum. Status Genitalis. Palpation of the scrotum organs without pathology. Per rectum: the ampoule is free. The prostate is somewhat thickened, inhomogeneously compacted, the groove is smoothed. Palpation is painful. The secret of the prostate: 35-40 leukocytes, few lecithin grains. Sowing on the microflora - noted the growth of Staph.aurig. 500 thousand. The patient was prescribed pyobacteriophage at a dose of 20 ml x 4 times a day for 7 days. In the first two days, he was given microclysters with EVR anolyte, in the next 5 days - with EVR catholyte with a complete set of trace elements (Zn, Mg, Mn) with the addition of Dimexide to aqueous solutions according to the above scheme. During the treatment, the pain syndrome was completely stopped, the secret of the prostate was sanitized, the tone of the prostate gland improved. The control examination was carried out after 6 months. In the secret of the prostate, there are 5-7 leukocytes in the field of view, there are a lot of lecithin grains, no growth of pathogenic flora was noted. Example 2. Patient I., 36 years old. Businessman. D-h: chronic prostatitis with a continuously relapsing course since 1987. Repeatedly received complex treatment, including tetracyclines, macrolides and fluoroquinolones. As a result, intolerance to many drugs has developed. In 1995 he was treated for dysbacteriosis of the large intestine. Upon admission - complaints of pain in the perineum, cramps when urinating, decreased libido and lethargy of erection. Status genitalis: external genitalia without pathology. Per recturn: the ampoule is free. The prostate is flattened, hypotonic, with focal seals, the groove is smoothed. Palpation is painful. There are few lecithin grains in the secret of the prostate gland, up to 70 leukocytes per field of view. The growth of Proteus vulgaris, resistant to all antibiotics - 1 million. The patient was prescribed pyobacteriophage 20 ml x 4 times a day with simultaneous warm microclysters according to the above scheme. After 3 days, the patient noted a significant improvement, and by the 8th day of treatment - the cessation of pain and dysuria. Test data by the end of treatment: 10-12 leukocytes in the field of view, there are a lot of lecithin grains. The growth of pathogenic flora was not observed. Control analysis - after 8 months. There are no complaints. No recurrence of the disease was noted.
Claim
A method for the treatment of chronic prostatitis, including etiopathogenetic therapy, characterized in that etiotropic therapy is carried out by oral administration of pyobacteriophage 20 ml 4 times a day for 5 to 7 days, and pathogenetic therapy includes microclysters with electroactivated aqueous solutions of salts of Zn, Mg, Mn, prepared on the apparatus "Espero-1", and in the first two days - with anolyte, and in the next 5 - 7 days - with the catholyte of these solutions, to which dimexide is added at the rate of 4 ml per 100 ml of solution.
Inflammation of the prostate gland is a common male disease, and the treatment of prostatitis with bacteriophages is effective for a number of reasons, which will be highlighted in detail in the article. According to statistics, 80% of men experience prostatitis during their lifetime. Moreover, approximately 30% of patients fall into the age category from 20 to 40 years. The prostate is located under the bladder and surrounds the urethra (urethra).
The most dangerous manifestation of prostatitis is the complete inability to urinate.
When an inflammatory process begins to develop in the prostate gland, the urethra is pinched by the prostate, because due to inflammation, it begins to increase in size. The disease is manifested by difficulty with urination. The disease is curable, but with careless treatment it can become chronic, and in the last stages of development, surgery is often required.
Signs of the development of prostatitis
With prostatitis, the patient begins to feel weakness, general performance worsens, body temperature rises. A man has frequent urge to urinate, but the pressure is weak and there is a feeling of pain in the bladder. Additionally, there may be a burning sensation in the perineum, pain in the intestines during bowel movements. If the patient has purulent inflammation, then pieces of pus may come out of the urethra and anus. These are the main symptoms that occur with prostatitis, both acute and chronic.
The most dangerous manifestation of the disease is the complete impossibility of urination. This condition requires the patient to be placed in a hospital for the installation of a catheter so that stagnant urine comes out. There are also signs that initially pay little attention and do not associate them with prostatitis, but they may indicate it:
- Deterioration of erection for no apparent reason, or even its complete loss;
- Painful or accelerated ejaculation;
- Prolonged erection at night during sleep.
If you pay attention to these uncomplicated symptoms in time and contact a specialist, then it will be much easier to cure the disease.
Causes of prostatitis
Most often, the inflammatory process in the prostate gland occurs for a number of reasons:
- Sedentary lifestyle or obesity, which cause impaired blood circulation in the pelvic area.
- Infectious lesions that can lead to complications. Often inflammation of the prostate occurs after past illnesses such as: gonorrhea, urethritis, tuberculosis, tonsillitis or influenza.
- The entry of pathogenic microflora into the prostate through lymph, sexual contact or blood. Staphylococci, streptococci can easily penetrate the prostate gland, and if a man's immunity is weak, then a disease develops.
- Injuries, hypothermia and physical inactivity can also contribute to the appearance of the disease.
- Inflammation in the rectum or frequent constipation.
- Too active sex life.
The main way to treat prostatitis is the use of antibiotic therapy, but it has a number of negative effects that can be avoided if bacteriophages are used.
Treatment of prostatitis with bacteriophages
Due to the fact that most often prostatitis occurs due to a urological infection, which is complicated by the bacterial flora, a certain number of antimicrobial drugs are used in the treatment. Before starting antibiotic treatment, you need to find out exactly which pathogenic microflora provoked the inflammatory process. After identifying the pathogen, an antibiotic is prescribed, but there are times when the antibiotic did not help, and then it is necessary to change the method of treatment.
There is always a risk of bacteria developing resistance to a particular antibacterial drug, and this method of treatment is also not suitable for people with gastrointestinal diseases. In this case, bacteriophages from prostatitis are used in the treatment. They are good because they do not damage the lining of the stomach, are very effective, are quickly excreted from the body and help, do not cause side effects, and they can also be combined with other medicines, including antibiotics. The essence of bacteriophages is that they destroy the shell of bacteria by introducing a microbe into the cell.
M. Kameneva
Cand. biol. Sci., Senior Microbiologist, Department of Diphtheria Toxoids and Bacteriophages, NPO "Biomed"
What medicine should be preferred if the cause of the disease is a pathogenic microflora? In any pharmacy you will be offered a wide range of antibiotics, but sometimes not only patients, but even pharmacists and doctors do not know about bacteriophages. And this is understandable. Throughout their history, bacteriophages have experienced a general interest in them in the era of their inception, and almost complete oblivion in the 60-80s. However, in the last 5 years, interest in them has revived.
Both antibiotics and bacteriophages act directly on microbes, only antibiotics destroy not only pathogenic, but also normal microflora, disturbing the natural balance, while bacteriophages act only on pathogenic microorganisms. Such selective action is due to their nature. Bacteriophages are viruses of bacteria. When a phage encounters a sensitive microbial cell, it penetrates inside it, switches its mechanism of action to reproduce its own kind, which, breaking the cell membrane, attack other microbes tenfold. Lysis becomes spontaneous, and the release of unwanted microbes occurs in a matter of hours.
Phagolysis - the destruction of bacteria by phages - is a natural process that occurs in an organ affected by bacteria during spontaneous recovery. And if, for some reason, self-healing does not occur, the body can be helped by introducing the appropriate bacteriophage obtained under production conditions. The phage is named after the microbe it acts on. Salmonella, typhoid, dysentery, staphylococcal, Klebsiella, Pseudomonas aeruginosa, Proteus, coli, streptococcal - this is an incomplete list of phages currently produced by domestic enterprises. We should also mention complex preparations, which are a set of phages for several pathogens at once: this is a pyobacteriophage for the treatment of purulent-septic diseases and an intestibacteriophage against intestinal infections. The main manufacturers of bacteriophages in our country are NPO Immunopreparat (Ufa), an enterprise for the production of bacterial preparations (Nizhny Novgorod), MP Biofon (Saratov), NPO Biomed (Perm).
Clinical practice has shown the effectiveness of the use of bacteriophages in infectious diseases gastrointestinal tract, as well as in inflammatory diseases of the sinuses, oral cavity, upper respiratory tract, genitourinary system, cholecystitis, etc., caused by bacteria sensitive to phage.
However, phages, these ""natural orderlies"", can be used not only for treatment, but also for prevention. infectious diseases. They are non-toxic, have no contraindications for use, and can be used in combination with any other drugs. They can be prescribed to pregnant women, nursing mothers and children of any age, including premature babies. The main condition for their successful application is to test the isolated culture for sensitivity to the corresponding phage. An amazing regularity was noted: unlike antibiotics, the sensitivity of clinical strains of microorganisms to bacteriophages is stable and tends to increase, which can be explained by the enrichment of medicinal preparations with new races of phages.
Staphylococcal bacteriophage today lyses over 90% of staphylococci isolated from purulent-inflammatory diseases. In addition to medical applications, bacteriophages are widely used in veterinary medicine; especially effective staphylococcal bacteriophage in the treatment of mastitis in cows. Bacteriophage preparations are prescribed orally for diseases of the internal organs or locally, directly on the lesion. The action of the phage is manifested already 2-4 hours after its introduction (which is especially important in intensive care). Bacteriophages penetrate into the blood, lymph and are excreted through the kidneys, sanitizing the urinary tract.
The activity of a bacteriophage is expressed by the degree of its dilution, at which complete lysis of a sensitive test culture occurs. For example, a titer of 10-6 means that the phage exhibits its lytic effect when diluted 1,000,000 times. Liquid phage preparations retain their activity from 6 to 12 years at a temperature of (6–4) 0 C in a place protected from light.
More than 100 years have passed since the first mention of phages, even before their official discovery by d "Erel in 1917. In 1896, Hankin, trying to explain the strong antibacterial effect of the waters of the Ganges and Jumna rivers in India, first described an agent that passes through bacterial filters and causes lysis of microbes, but is destroyed by boiling. Subsequently, d "Erel gave him the name bacteriophage? "eater of bacteria" The first report of successful phage therapy known to science was made in 1921 by Brijong and Maisin, who used a staphylococcal bacteriophage to treat contagious skin diseases. In the 1920s, phages were actively used in the treatment various diseases. However, in the 1940s they were supplanted by antibiotics, and in the West they were completely forgotten about phages.
Today at Western countries interest in phages has been reawakened. The impetus for this was the growing number of antibiotic-resistant microorganisms, especially staphylococci and Pseudomonas aeruginosa. Moreover, not only specialists are interested in bacteriophages, but even politicians. US Vice President Al Gore called phages "a new weapon to fight pathogenic bacteria." IN last years defended a number of doctoral dissertations on practical application bacteriophages, for example, in Finland - on the inclusion of the latter in yoghurts. Several American firms began to produce phages.
Looking at the scale with which the production of phages in the West is beginning to improve, one can confidently predict that in ten years their production will become one of the leading industries in the pharmaceutical industry.
»» № 6 "98
Despite the variety of drugs offered for chemotherapy bacterial diseases(more than 600 items, including more than 100 antibiotics), urinary tract infections still rank first among all hospital-acquired infections.
Difficulties in the treatment of urological infections are due to many factors. The introduction of endoscopic interventions (both therapeutic and diagnostic) and high technologies in urological practice, in addition to positive aspects, has introduced a number of problems: new entry gates of infection have opened, the number of operated patients of elderly and senile age with weakened immunity has increased. Permanent drains, stones, and residual urine serve as colonization and breeding grounds for hospital microbiota. The predominance of the role of opportunistic microorganisms in the development of hospital urological infection has led to a decrease in the effectiveness of treatment and created difficulties in the selection of therapeutic drugs, especially for patients suffering from chronic inflammatory diseases of the kidneys and urinary tract. Initial, natural, resistance to old antibiotics does not disappear, and bacteria gradually improve resistance mechanisms and develop protection factors against new groups of antibiotics, such as 3rd generation cephalosporins or fluoroquinolones. Antibiotics create a selective background for the gradual spread of strains of microorganisms resistant to them and the wide distribution of information exchange mechanisms in nature.
Antibacterial treatment can cause the development of dysbacteriosis. In the case of the use of antibiotics against the background of the developed dysbacteriosis of the intestinal tract, antibacterial therapy can increase the degree of its severity. In addition, antibiotics reduce the colonization resistance of the intestine, increase the permeability of the intestinal wall, facilitating the penetration of opportunistic microorganisms into the bloodstream, internal organs and the development of a secondary focus of infection. Bacteriophage preparations have good prospects as antibacterial therapy.
Therapeutic and prophylactic bacteriophages contain polyclonal virulent bacteriophages with a wide range of action, including active against bacteria resistant to antibiotics. Phage therapy can be successfully combined with the prescription of antibiotics.
Currently, bacteriophage preparations are being produced in Russia against the main pathogens of hospital infection, such as staphylococcal, streptococcal, Klebsieleus, Proteus, Pseudomonas aeruginosa, coliphage (NPO Immunopreparat, Ufa; enterprise for the production of bacterial preparations, Nizhny Novgorod; MP " Biofon", Saratov). The advantage of these drugs lies in the strict specificity of the action, since they cause the death of only their specific type of bacteria, without affecting, unlike antibiotics, the normal intestinal microflora of the patient. The use of bacteriophages has shown good results in the treatment of dysbiosis, surgical, urogenital, ENT infections.
Domestic neonatologists have shown the high efficiency of phage therapy for purulent-septic infections in young children. In addition to the lytic effect on microbes, their importance in the mechanism of antitoxic, cellular and humoral immunity is noted.
In the Research Institute of Urology of the Ministry of Health of the Russian Federation, together with the Research Institute for Standardization and Control of Medical and Biological Preparations named after V.I. L.A. Tarasovich and NPO "Immunopreparat" during 1993-1994. a study was made of the clinical efficacy of bacteriophage preparations in the treatment of patients with inflammatory urological diseases.
Phage therapy was used mainly in the treatment of chronic infectious and inflammatory urological diseases: chronic cystitis, chronic pyelonephritis, chronic prostatitis, urethritis, suppuration of wounds, in some cases in acute purulent-septic conditions of patients - a total of 46 people. Liquid bacteriophages were used for treatment: Pseudomonas aeruginosa, Proteus, coliphage, staphylococcal and combined pyobacteriophage containing the listed phages. Phages were used topically: through drains into the bladder (50 ml 1-2 times a day), into the wound (10-20 ml), into the renal pelvis (5-7 ml), and inside (daily dose of 100 ml per day). day 30 minutes before meals). The course of treatment is 7-10 days.
Satisfactory clinical analyzes were obtained already on the 2-4th day of treatment with bacteriophages: a decrease in the symptoms of general intoxication, dysuria, a decrease in body temperature, and an improvement in bowel function (especially in children).
The overall bacteriological efficacy was over 84%, clinical - over 92%. The clinical efficacy of phage therapy is almost comparable to the activity in the control group of patients who were treated with modern antibiotics - fluoroquinolones.
Thus, bacteriophage therapy for urinary tract infections is an effective independent type of treatment or can be used in combination with antibacterial chemotherapy.
Being a harmless biological method of treatment, bacteriophage therapy can be used in young children. For getting positive results The use of bacteriophages requires a preliminary study of the sensitivity of microorganisms to them. When using bacteriophages in large clinics, it is advisable to include in the composition of industrial strains on which commercial preparations are prepared, hospital strains of causative agents of purulent-inflammatory diseases characteristic of this hospital. Domestic preparations of bacteriophages are relatively cheap, which is of great economic importance in the treatment of patients with urological infections.