In this article, you can read the instructions for using the drug Flemoxin Solutab. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Flemoxin Solutab in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Flemoxin Solutab in the presence of existing structural analogues. Use for the treatment of tonsillitis, sinusitis and other infections in adults, children, as well as during pregnancy and lactation.
Flemoxin Solutab- an antibiotic of the group of semi-synthetic penicillins with a wide spectrum of action. It is a 4-hydroxy analogue of ampicillin. It has a bactericidal effect. Active against aerobic Gram-positive and Gram-negative bacteria.
Microorganisms that produce penicillinase are resistant to amoxicillin (the active substance of the drug Flemoxin Solutab).
In combination with metronidazole, it is active against Helicobacter pylori. Amoxicillin is believed to inhibit the development of Helicobacter pylori resistance to metronidazole.
Cross-resistance exists between amoxicillin and ampicillin.
The spectrum of antibacterial action is expanded with the simultaneous use of amoxicillin and the beta-lactamase inhibitor clavulanic acid. This combination increases the activity of Flemoxin Solutab against Bacteroides spp., Legionella spp., Nocardia spp., Pseudomonas (Burkholderia) pseudomallei. However, Pseudomonas aeruginosa, Serratia marcescens and many other Gram-negative bacteria remain resistant.
Pharmacokinetics
When taken orally, Flemoxin Solutab is rapidly and completely absorbed from the gastrointestinal tract, is not destroyed in the acidic environment of the stomach. When the dose is increased by 2 times, the concentration also increases by 2 times. In the presence of food in the stomach does not reduce overall absorption. Widely distributed in tissues and body fluids. High concentrations of amoxicillin in the liver have been reported (therefore, the simultaneous intake of ethanol (alcohol) negatively affects this organ with the possibility of developing liver failure).
About 60% of an oral dose is excreted unchanged in the urine by glomerular filtration and tubular secretion. A certain amount of amoxicillin is determined in the feces.
In small amounts, amoxicillin penetrates the BBB during inflammation of the pia mater.
Indications
- infectious and inflammatory diseases (respiratory, genitourinary, skin) caused by susceptible microorganisms, incl. bronchitis, pneumonia, tonsillitis, pyelonephritis, urethritis, gastrointestinal infections, gynecological infections, infectious diseases of the skin and soft tissues, listeriosis, leptospirosis, gonorrhea;
- For use in combination with metronidazole: chronic gastritis in the acute phase, peptic ulcer of the stomach and duodenum in the acute phase, associated with Helicobacter pylori.
Release forms
Dispersible tablets 125 mg, 250 mg, 500 mg and 1000 mg.
Instructions for use and dosage
The drug is taken orally. The drug is prescribed before, during or after a meal. The tablet can be swallowed whole, divided into parts or chewed with a glass of water, and can also be diluted in water to form a syrup (in 20 ml) or suspension (in 100 ml) with a pleasant fruity taste.
The dosage regimen is set individually, taking into account the severity of the course of the disease, the sensitivity of the pathogen to the drug, the age of the patient.
In the case of infectious and inflammatory diseases of mild to moderate severity, it is recommended to use the drug according to the following scheme: adults and children over 10 years old are prescribed 500-750 mg 2 times a day or 375-500 mg 3 times a day; children aged 3 to 10 years are prescribed 375 mg 2 times a day or 250 mg 3 times a day; children aged 1 to 3 years are prescribed 250 mg 2 times a day or 125 mg 3 times a day.
The daily dose of the drug for children (including children under 1 year old) is 30-60 mg / kg per day, divided into 2-3 doses.
In the treatment of severe infections, as well as in hard-to-reach foci of infection (for example, acute otitis media), a three-time dose is recommended.
In chronic diseases, recurrent infections, severe infections, adults are prescribed 0.75-1 g 3 times a day; children - 60 mg / kg per day, divided into 3 doses.
In acute uncomplicated gonorrhea, 3 g of the drug is prescribed in 1 dose in combination with 1 g of probenecid.
For patients with impaired renal function with CC≤10 ml / min, the dose of the drug is reduced by 15-50%.
In case of infections of mild and moderate severity, the drug is taken for 5-7 days. However, for infections caused by Streptococcus pyogenes, the duration of treatment should be at least 10 days.
The drug should be continued for 48 hours after the disappearance of the symptoms of the disease.
Side effect
- taste change;
- nausea, vomiting;
- diarrhea;
- dysbacteriosis;
- stomatitis, glossitis;
- hepatic cholestasis;
- pseudomembranous and hemorrhagic colitis;
- leukopenia, neutropenia, thrombocytopenic purpura, eosinophilia, thrombocytopenia, agranulocytosis, hemolytic anemia;
- excitement, anxiety;
- insomnia;
- ataxia;
- confusion;
- behavior change;
- depression;
- peripheral neuropathy;
- headache;
- dizziness;
- skin reactions, mainly in the form of a specific maculo-papular rash;
- hives;
- skin hyperemia;
- erythematous rashes;
- rhinitis;
- conjunctivitis;
- arthralgia;
- toxic epidermal necrolysis;
- allergic vasculitis;
- anaphylactic shock;
- angioedema;
- labored breathing;
- vaginal candidiasis;
- superinfection (especially in patients with chronic diseases or reduced body resistance).
Contraindications
- hypersensitivity to the components of the drug;
- hypersensitivity to other beta-lactam antibiotics, incl. to other penicillins, cephalosporins, carbapenems.
Use during pregnancy and lactation
The use of the drug Flemoxin Solutab during pregnancy and lactation is possible if the expected benefit of therapy for the mother outweighs the risk of side effects in the fetus and infant.
In small amounts, amoxicillin is excreted in breast milk, which can lead to the development of sensitization phenomena in an infant.
Use in children
It is used in children according to indications according to the dosing regimen (including infants and newborns).
special instructions
Prescribe the drug to patients with infectious mononucleosis and lymphocytic leukemia should be used with caution, since there is a high probability of non-allergic exanthema.
The presence of erythroderma in history is not a contraindication for the appointment of the drug Flemoxin Solutab.
Cross-resistance with penicillins and cephalosporins is possible.
The appearance of severe diarrhea, characteristic of pseudomembranous colitis, is an indication for discontinuation of the drug.
During the course of treatment, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.
Perhaps the development of superinfection due to the growth of microflora insensitive to the drug, which requires a corresponding change in antibiotic therapy.
With the simultaneous use of estrogen-containing oral contraceptives and amoxicillin, other or additional methods of contraception should, if possible, be used.
Influence on the ability to drive vehicles and control mechanisms
There were no reports of adverse effects of the drug on the ability to drive vehicles or work with mechanisms.
drug interaction
Probenecid, phenylbutazone, oxyphenbutazone, diuretics, allopurinol, NSAIDs, to a lesser extent - acetylsalicylic acid and sulfinpyrazone inhibit the tubular secretion of penicillins, which leads to an increase in T1 / 2 and an increase in the concentration of amoxicillin in the blood plasma.
Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) show synergism when taken simultaneously.
Possible antagonism when taken with some bacteriostatic drugs (eg, chloramphenicol, sulfonamides).
Simultaneous administration of Flemoxin Solutab with estrogen-containing oral contraceptives may reduce the effectiveness of the latter and increase the risk of acyclic bleeding.
Antacids, glucosamine, laxative drugs, aminoglycosides, food reduce absorption. Ascorbic acid increases absorption.
Increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index); enhances the absorption of digoxin.
The simultaneous use of amoxicillin with allopurinol increases the risk of skin rash.
Analogues of the drug Flemoxin Solutab
Structural analogues for the active substance:
- Amoxisar;
- Amoxicillin;
- Amoxicillin DS;
- Amoxicillin sodium sterile;
- Amoxicillin Sandoz;
- Amoxicillin-ratiopharm;
- Amoxicillin trihydrate;
- Amosin;
- Gonoform;
- Grunamox;
- Danemox;
- Ospamox;
- Hyconcil;
- Ecoball.
In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.
Flemoxin is a generic of one of the most popular antibiotics in the world -. The original drug was developed by British pharmacists in the 60s of the last century. Amoxicillin appeared on the pharmaceutical market in the early 70s.
Amoxicillin is without a doubt one of the safest broad spectrum antibacterial drugs. According to some reports, this penicillin antibiotic is almost the most prescribed medicine in pediatrics. Almost every reputable pharmaceutical company considers it their duty to release their "Amoxicillin". The Japanese corporation Astellas Pharma also succeeded in this matter by developing Flemoxin.
Flemoxin Solutab stands out against the monotonous background of Amoxicillins due to its release form. After all, the drug is available in the form of dispersible tablets, which have a lot of advantages compared to the pills we are used to.
In this article, we will try to understand how Flemoxin differs from analogues, as well as to clarify the positive aspects of the drug. And we will not bypass the negative qualities, which, of course, are also present.
Astellas Pharma: new life for antibiotics
Astellas Pharma is the largest Japanese pharmaceutical concern. It appeared in 2005 through the merger of two well-known Japanese companies: Fujisawa Pharmaceutical Co and Yamanouchi Pharmaceutical Co.
Today, Astellas Pharma works in various areas of medicine, creating both original drugs and analogues of well-known brands. The company also produces several antibiotics, which have become widely known due to the dispersible form of release.
Each of these medicines has an additional word in the name, indicating a special form - solyutab. Dispersible preparations include:
- cephalosporin antibiotic Ceforal Solutab;
- Unidox Solutab, widely known in Russia;
- Wilprafen Solutab;
- Flemoxin Solutab and Flemoklav Solutab are two related drugs containing Amoxicillin as an active ingredient.
I would like to note that Flemoxin Solutab is registered only in Germany, Iceland, Portugal and the CIS countries.
>>Recommended: if you are interested in effective methods of getting rid of chronic rhinitis, pharyngitis, tonsillitis, bronchitis and constant colds, then be sure to check out this website page after reading this article. The information is based on the personal experience of the author and has helped many people, we hope it will help you too. Now back to the article.<<
Flemoxin solutab: composition of the drug
The composition of Flemoxin includes, as you already understood, the only active ingredient - Amoxicillin - in the form of a stable compound (trihydrate).
Pharmaceutics is developing every day, releasing more and more new drugs on the shelves of the pharmacy network. Especially often you can find medicines with the prefix "Solutab". Do these drugs have similarities? What is the difference between Unidox Solutab and Flemoxin Solutab, this article will tell.
What is Solutab
Before making a comparison, it is necessary to find out what the prefix “Solutab” means. This word means that the drug has a special form of release.
All antibiotics released in the form of Solutab have the following features:
- The main active ingredient is enclosed in special microspheres that make the antibiotic resistant to the acidic environment of the stomach;
- Solutab antibiotics are highly effective and rapidly absorbed. Therefore, this form of release is considered an analogue of injections;
- The medicine is highly soluble in water.
It turns out that Unidox and Flemoxin have a common release form.
Comparison of drugs
To compare Flemoxin and Unidox, you need to find out what these drugs are.
Flemoxin is an antibacterial agent of the penicillin series based on amoxicillin trihydrate. The antibiotic has a wide spectrum of action, detrimental to gram-positive and gram-negative microorganisms. The drug is actively used in the treatment of diseases of the skin, respiratory, digestive, urinary systems caused by bacterial flora.
Flemoxin has a small list of contraindications and side effects, so it is often used in pediatrics, as well as for the treatment of pregnant and lactating women.
Unidox is an antibiotic of the tetracycline group. The main active ingredient is doxycycline. Unidox has a wide range of effects, providing a bacteriostatic effect on microorganisms. The therapeutic effect is to stop the reproduction of pathogenic microflora.
Unidox indications:
- Respiratory system infections;
- Diseases of the digestive system;
- Actively fights inflammation on the skin in the form of acne, blackheads;
- Infections of the urinary and reproductive system;
Unidox Solutab differs from Flemoxin Solutab in a list of contraindications. Antibiotic Unidox is not used in children under 8 years of age. This is due to the fact that when taken in young children, there is a risk of formation in the body of insoluble complexes with calcium in the bone marrow, as well as in the teeth.
As a result, the child has:
- Enamel hyperplasia, characterizing its underdevelopment;
- The color of the teeth changes. They turn yellow;
- Slows down bone growth.
Also, the drug should not be used by lactating and pregnant women.
Drug differences
Unidox and Flemoxin have the following differences:
- The drugs belong to different groups of antibiotics. Therefore, if one drug is not suitable for the treatment of an infectious disease, then the drug can be replaced with another antibiotic;
- Safety. Flemoxin is a safer drug;
- Mechanism of action on microorganisms. Flemoxin has a bactericidal effect, and Unidox is bacteriostatic;
- Unidox has a much larger list of indications than Flemkosin. This means that it has a wider spectrum of action.
Can be taken together
In rare cases, a doctor may prescribe two antibiotics at the same time, with a complicated or combined infection. The instructions also indicate that when doxycycline interacts with bactericidal antibiotics, such as penicillin, the therapeutic effect is reduced. Therefore, it is undesirable to take Unidox and Flemoxin together.
From the foregoing, we can conclude that these two drugs are completely different antibiotics, despite the same word present in the name.
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Flemoxin Solutab® (lat. Flemoxin Solutab®) is an antibiotic of the penicillin class. The active substance is amoxicillin.
Dosage forms of flemoxin solutab
Flemoxin Solutab is available as dispersible (soluble) tablets containing 125, 250, 500 or 1000 mg of amoxicillin (as amoxicillin trihydrate). Tablets are white to light yellow, oval, from white to light yellow in color with the company's logo and digital designation on one side and a line dividing the tablet in half on the other side. The number on the tablet indicates the content of amoxicillin:- "231" - the tablet contains 125 mg of amoxicillin
- "232" - the tablet contains 250 mg of amoxicillin
- "234" - the tablet contains 500 mg of amoxicillin
- "236" - the tablet contains 1000 mg of amoxicillin
Indications for use of flemoxin solutab
Flemoxin solutab is used in the treatment of infectious and inflammatory diseases caused by microbes sensitive to flemoxin slyutab, including:
- respiratory infections
- infectious diseases of the genitourinary system
- infectious diseases of the skin and soft tissues
- infectious diseases of the gastrointestinal tract, including Helicobacter pylori-associated gastric and duodenal ulcers, atrophic gastritis, MALTomas.
Flemoxin solutab in gastroenterology
Gastroenterologists most often use flemoxin solutab as one of the antibiotics as part of complex therapy for eradication Helicobacter pylori. Flemoxin solutab is not used for eradication Helicobacter pylori outside special schemes, without drugs that reduce the acidity of the stomach. The doses and procedure for taking flemoxin solutab depends on the eradication "scheme" used (see the article "Amoxicillin" or "Standards for the diagnosis and treatment of acid-dependent and Helicobacter pylori-associated diseases (fourth Moscow agreement)")Flemoxin solutab is also not used in any form for the treatment of peptic ulcer of the stomach and duodenum or gastritis in the absence of Helicobacter pylori.
Method of application of flemoxin solutab and doses
Flemoxin Solutab is taken orally, before, during or after a meal, swallowed whole, or divided into parts or chewed, washed down with a glass of water or diluted in water to form a syrup (in 20 ml) or suspension (in 100 ml).Adults and children over 10 years old, with mild to moderate infections - 500-750 mg 2 times a day or 375-500 mg 3 times a day.
Children from 3 to 10 years - 375 mg 2 times a day or 250 mg 3 times a day; from 1 to 3 years - 250 mg 2 times a day or 125 mg 3 times a day. The daily dose of flemoxin solutab for children under 1 year old is 30–60 mg per kg of body weight, divided into 2–3 doses.
In the treatment of severe infections and with hard-to-reach foci, it is desirable to take flemoxin solutab three times.
In chronic diseases, relapses, severe infections: adults - 0.75–1 g 3 times a day, children - up to 60 mg per kg per day; the dose calculated in this way is divided into 3 doses.
In acute uncomplicated gonorrhea - 3 g once, in combination with 1 g of probenecid.
For infections of mild and moderate severity, treatment with flemoxin solutab is 5–7 days, for infections caused by Streptococcus pyogenes, - not less than 10 days.
In the treatment of chronic diseases, severe infections, the dose of flemoxin solutab should be determined by the clinical picture of the disease. Reception of flemoxin solutab is continued for two days after the disappearance of the symptoms of the disease.
With a creatinine clearance of less than 10 ml per minute, the dose of flemoxin solutab is reduced by 15–50%.
Professional medical articles regarding the use of flemoxin solutab for eradicationHelicobacter pylori
- Potapov A.S., Pakhomovskaya N.L., Dublina E.S. Evaluation of the effectiveness and safety of triple eradication therapy for helicobacteriosis in children with drugs chelol, de-nol and flemoxin solutab // Almanac of Clinical Medicine. - 2006. - Volume XIV. - With. 87–94.
- Samsonov A.A., Maev I.V., Ovchinnikova N.I., Shakh Yu.S., Podgorbunskikh E.I. The effectiveness of the use of colloidal bismuth subcitrate in the schemes of eradication therapy for Helicobacter pylori in duodenal ulcer // RJGGK. 2004. No. 4. pp. 30–35.
Other medicines containing the active ingredient amoxicillin
Amoxicillin, Amoxicillin, Amoxicillin capsules 0.25 g, Amoxicillin DS, Amoxicillin sodium sterile, Amoxicillin Sandoz, Amoxicillin-ratiopharm, Amoxicillin-ratiopharm 250 TS, Amoxicillin powder for suspension 5 g, Amoxicillin tablets, Amoxicillin trihydrate, Amoxicillin trihydrate (Purimox) , Amosin Gonoform, Gramox-D, Grunamox, Danemox, Ospamox, Hikoncil, Ecobol.general information
According to the pharmacological index, flemoxin solutab belongs to the group "Penicillins", according to ATC - to the group "Broad-spectrum penicillins" and has the code "J01CA04 Amoxicillin".Flemoxin solutab is a generic of amoxicillin and therefore information about its medicinal properties, including: indications for use, dosing regimen, a list of microorganisms against which flemoxin solutab is active, flemoxin solutab in eradication schemes, antibiotic resistance Helicobacter pylori to flemoxin solutab (amoxicillin), preservation during therapy with flemoxin solutab, pharmacokinetics of flemoxin solutab, interaction of flemoxin solutab with other drugs, contraindications when taking flemoxin solutab - see the article "Amoxicillin".
The manufacturer of Flemoxin Solutab is Astellas Pharma Europe B.V. (Astellas Pharma Europe B.V.), Holland.
Manufacturer's instructions (pdf): "Instruction (information for specialists) on the medical use of the drug Flemoxin Solutab".
Flemoxin Solutab has contraindications and features of use, consultation with a specialist is necessary before starting therapy.
The drug Flemoxin Solutab is an antibacterial drug. The composition, if indicated for use, is used in pediatric and therapeutic practice. The antibiotic belongs to the group of semi-synthetic penicillins with a wide spectrum of activity. The drug is a 4-hydroxy analogue.
Dosage form
The drug is produced in the form of tablets intended for oral administration.
Description and composition
Dispersible tablets have a color from white to light yellow. The drug has an oval shape with the company logo and the digital designation 236 on one side and a line dividing the tablet into 3 parts on the back. The main active ingredient is 3 1. The list of auxiliary components of the drug can be presented as follows:
- raspberry lemon flavor;
- flavoring vanillin;
- crospovidone;
- magnesium stearate;
- saccharinate;
- cellulose microcrystalline.
Pharmacological group
The antibacterial agent belongs to the group of semi-synthetic penicillins with a wide spectrum of activity. The composition is a 4 hydroxyl analog. The agent has a pronounced bactericidal effect. The drug is active against aerobic gram-positive bacteria and gram-negative anaerobic bacteria.
Rarely observed hepatitis, colitis, allergic reactions, interstitial nephritis. When taken in combination with clavulanic acid, liver disorders may occur.
Interaction with other drugs
Data on drug interactions indicate that it significantly reduces the effectiveness of contraceptives intended for oral administration. Women should look for another method of preventing unwanted pregnancies.
When taken simultaneously with bactericidal antibiotics, synergism is manifested.
When taken with bacteriostatic and antibiotics, antagonism.
The drug enhances the effect of indirect anticoagulants suppressing the intestinal flora.
A decrease in the prothrombin index is possible.
special instructions
With caution, the drug is used by people who are prone to allergic reactions. During the use of the drug, you should stop drinking alcoholic beverages. in combination with is not recommended for patients under the age of 18 years.
Overdose
Against the background of taking the drug in doses significantly exceeding the adverse reactions regulated by the instructions, they can manifest themselves with greater intensity. Treatment consists in the abolition of the used medicinal composition. If the patient's health deteriorates sharply, it is necessary to seek qualified medical help.
Storage conditions
Flemoxin Solutab should be stored at a temperature not exceeding 25 degrees. The maximum storage time is 2 years from the date of issue.
The drug is sold to the public through a network of pharmacies in free sale.
Analogues
The drug Flemoxin Solutab has a sufficient number of analogues that can act as its applicant. The list of analogues includes all drugs containing in the composition.
It is considered as the most popular analogue, which is a substitute for flemoxin. The composition is designed specifically to eliminate infectious processes and subsequent inflammatory processes in the human body.