Corvalol is a drug that has a sedative and hypnotic effect. Indications for its use are:
- intestinal spasms;
- initial stages of hypertension;
- insomnia;
- tachycardia;
- angina pectoris (in combination with nitrates);
- neuroses with increased irritability.
Source: serdcelechim.ru
Corvalol helps relieve nervous tension, eliminate the effects of stress, improve sleep. That is why it is often taken by many people, and often without a doctor's prescription. But the composition of this drug includes phenobarbital and long-term uncontrolled treatment with it leads to the formation of drug dependence, causes a rather life-threatening overdose. Therefore, in the EU and the USA, this remedy is sold in pharmacies only by prescription. Unfortunately, in Russia and the CIS countries Corvalol can be purchased by anyone and therefore cases of overdose are quite common.
For adults, Corvalol is usually prescribed 15-20 drops three times a day. And only in case of severe tachycardia, up to 40 drops can be taken once.
Over time, patients develop addiction to Corvalol and the usual doses of the drug cease to have the desired effect. As a result of this, they begin to take it in large dosages and much more often. If you take 10 ml of Corvalol, which corresponds to half a bottle, within a short time period, this will lead to overdose symptoms.
An overdose of Corvalol can also develop when taking low doses of the drug. This is observed when it is combined with alcohol, tranquilizers, antidepressants or sedatives, as they potentiate, that is, increase the inhibitory effect of the drug on the central nervous system.
Long-term treatment with Corvalol can cause not only the formation of drug dependence, but also a chronic overdose of the body with ethyl bromisovalerianate, which also leads to a number of pathological changes.
Signs of an overdose
An acute overdose of Corvalol occurs when a person accidentally or intentionally takes a very high dose of the drug, significantly exceeding the therapeutic one, for a short period of time.
Acute overdose of mild Corvalol usually manifests itself:
- drowsiness;
- weakness;
- dizziness;
- decreased concentration and performance;
- movement coordination disorders.
For an overdose of Corvalol of moderate severity, the following symptoms are characteristic:
- deep sleep, in which it is possible to wake a person with great difficulty;
- rapid heart rate (tachycardia).
With a severe overdose of Corvalol, the condition of patients worsens significantly. They are observed:
- violations of the correct rhythm of the heart;
- rapid shallow breathing;
- a sharp decrease in blood pressure;
- muscle twitching, turning into generalized convulsive seizures.
Source: depositphotos.com
Pronounced hypotension becomes the cause of the development of a collaptoid state in the patient, which later, against the background of increasing hypoxia of organs and tissues, passes into a coma. If the patient is not provided with urgent medical care, then a fatal outcome may occur.
Chronic overdose of Corvalol, or rather ethyl bromisovaleriant, which is part of it, manifests itself:
- indifference to the surrounding reality;
- depressive state;
- confusion of consciousness;
- conjunctivitis;
- rhinitis;
- the appearance of acne.
Long-term treatment with Corvalol leads to the formation of drug dependence, which is associated with the phenobarbital contained in the drug. Its presence can be assumed on the basis of the following signs:
- depressed mood;
- tired look;
- self-doubt;
- impaired concentration;
- inadequate reaction to loved ones.
The intensity of the severity of these signs significantly weakens after taking the next dose of Corvalol.
First aid for overdose
In case of acute overdose of Corvalol, it is necessary first of all to perform a gastric lavage. The patient is offered to drink about one liter of pure water, and then, by pressing the fingers of the hand on the root of the tongue, they cause him to vomit. This simple procedure should be performed at least 3-4 times in order to thoroughly cleanse the stomach of the remnants of the taken Corvalol.
After gastric lavage, the patient is allowed to take one of the sorbent preparations. It can be Smecta, Enterogel, Filtrum STI or Activated carbon. They absorb Corvalol contained in the digestive tract and retain it, preventing it from being absorbed and entering the bloodstream.
In case of an overdose of Corvalol, it is necessary to try to maintain contact with the patient, preventing him from falling asleep. If there is no severe vomiting, then it is often necessary to water the poisoned person, as this will increase the amount of urine separated and thereby accelerate the removal of Corvalol from the body.
With a chronic overdose of Corvalol or the development of drug dependence, the first first aid is to stop further use of this drug.
Antidote
There is no specific antidote for corvalol.
When is medical attention needed?
Even with mild degrees of overdose of Corvalol, you should definitely seek medical help, since at any time the condition of the victim may suddenly and dramatically worsen. Moreover, a visit to a doctor is necessary in case of an overdose of moderate and severe Corvalol.
In a hospital, patients with an overdose of Corvalol undergo gastric lavage using a gastric tube and begin symptomatic therapy aimed at preventing the development or restoring existing disorders of the cardiovascular system and respiratory failure.
For the speedy removal of Corvalol from the body, forced diuresis is performed with alkalization of the blood with sodium bicarbonate solution, hemosorption and / or extracorporeal hemodialysis.
In case of severe respiratory failure, tracheal intubation is performed and the patient is transferred to artificial lung ventilation.
For the treatment of chronic overdose of Corvalol, abundant salted drinking and the use of diuretics (Lasix, Veroshpiron, Hypothiazid) are indicated.
Therapy of drug dependence on Corvalol requires long-term therapy, which is carried out jointly by toxicologists, narcologists and psychotherapists.
Possible Complications
Severe degrees of overdose with Corvalol are quite dangerous. They can be fatal, even if timely medical attention is provided.
An overdose of Corvalol is often complicated by pneumonia, impaired renal function. In the long term, neurological disorders (depression, staggering gait) can be observed, which are caused by toxic and hypoxic encephalopathy.
In the elderly, chronic overdose can cause:
- reducing the reaction rate;
- memory impairment;
- difficult thinking;
- impaired coordination of movements.
All of the above often leads to falls in older people, which can lead to fractures.
Video from YouTube on the topic of the article:
Corvalol is a popular drug with a sedative effect. The drug has a wide range of indications, but contains phenobarbital, which requires careful use. The drug depresses the activity of the nervous system, thereby providing a sedative and hypnotic effect.
Everyone periodically encounters neuroses, insomnia and irritability. There are many drugs for the treatment of such conditions, and the most affordable of them is Corvalol. The drug has been used for more than half a century as a sedative. Nevertheless, not everyone knows that the usual and affordable remedy is unsafe.
As part of the drug:
- phenobarbital;
- ethyl ester of bromisovaleric acid;
- mint oil.
The drug is available in tablets and drops.
Release form Corvalol
Corvalol - drops often taken by hypertensive patients and people with sleep disorders. They act very quickly and provide a persistent sedative effect for a long time. However, phenobarbital is a psychotropic substance that is difficult to excrete from the body. This component makes Corvalol an effective sedative, but also causes the danger of abuse of drops or tablets.
Kovralol-drops contains alcohol and purified water as forming components. The medicine is available in small dark glass bottles equipped with a dispenser. Corvalol, the composition of which contains mint oil and valerian extract, has a specific smell and an easily recognizable bitter taste. The drug is a pale yellow oily liquid.
Corvalol tablets are admitted in cartons. Each package contains from 2 to 10 blisters, 10 tablets each. The composition is the same - phenobarbital, ethyl ester of valerian extract and natural mint oil. Lactose monohydrate, magnesium stearate and acesulfame calcium are used as forming components in the manufacture of tablets.
Some interesting facts about Corvalol:
- the drug has been produced since 1960;
- the medicine is practically unknown outside the former USSR;
- the active substance is a potent narcotic;
- Import of Corvalol is prohibited in some European countries and in the United States.
In Russia, Ukraine and Belarus, this drug is among the top five best-selling drugs.
Phenobarbital in the composition is the most dangerous ingredient
What does Corvalol treat?
The drug has a sedative and hypnotic effect. Taking Corvalol allows you to get rid of feelings of anxiety, fear, insomnia. The action of Corvalol is manifested in the inhibition of the nervous system.
The drug is widely taken by cores and hypertensive patients. A fairly common question for older people is how Corvalol works, increases or decreases blood pressure. Hypertensive patients drink 20-30 drops of Corvalol, which lowers blood pressure. Hypotensive patients take a drug to normalize sleep and improve well-being. At the same time, both groups of patients are sure that the medicine helps them. The truth is that Corvalol does not cure any diseases. Improving well-being when taking drops is due to the sedative effect of the drug.
The list of indications given in the instructions for use is quite large. It is suggested to take drops or tablets in the following cases:
- neurosis;
- increased irritability;
- insomnia;
- cardiopsychoneurosis;
- hypertension;
- tachycardia;
- vascular spasms.
The drug does not treat these conditions, but relieves symptoms due to sedative, antispasmodic and hypnotic effects. Simply put, taking Corvalol changes the patient's attitude to the disease by inhibiting the activity of the nervous system.
The tool allows you to get rid of the syndrome of hypochondria, reducing nervous excitability. With hypertension, an increase in pressure is always associated with stress and psycho-emotional stress. Corvalol inhibits the activity of the nervous system, thereby eliminating the cause of the increase in pressure, but does not directly affect the disease.
So what Corvalol helps with will depend on the exact symptoms. The drug will eliminate the symptoms of any ailments caused by a strong load on the nervous system. Drops can be drunk even with migraine - due to the calming effect, the intensity of pain perception changes and the impression of an analgesic effect of the drug taken is created.
How to drink Corvalol?
When using the drug, it is important to remember that an overdose of Corvalol can lead to dangerous complications and severe side effects. The fact is that this drug contains bromine (bromisovaleric acid ester). Accumulating in the body, this substance can cause severe disruption of the internal organs.
When taking Corvalol, instructions for use depend on the form of release. How many drops of Corvalol can be taken will depend on the symptoms. With neurosis, irritability and anxiety, the recommended dose of Corvalol is from 15 to 30 drops. The remedy is diluted in a small amount of water and taken three times a day.
With tachycardia and severe conditions caused by vasospasm, you can take 40 drops of Corvalol. This is the maximum allowable dosage for one dose. To make the medicine work faster, it is dripped onto a piece of refined sugar, which is then absorbed. In addition, how Corvalol is drunk also depends on the sensitivity of taste buds. Some people can take the drops sublingually without water, noting the rapid onset of the therapeutic effect. For most patients, the optimal method of taking the medicine is the use of sugar.
For insomnia, take 30 drops of the drug half an hour before going to bed. Short-term use of Corvalol in drops is allowed. Excretion of the drug from the body occurs within 20 hours after taking a therapeutic dose. The longer a person takes Corvalol, the more difficult it is for the body to cope with it.
How to take Corvalol tablets? The instruction suggests drinking 1 tablet 2 or 3 times a day. The drug acts faster if the tablet is not swallowed with water, but put under the tongue and wait for complete dissolution. With tachycardia, a single dose of three tablets at once is allowed. For insomnia, drink 1-2 tablets half an hour before bedtime.
Having figured out how much and in what quantities you can drink Corvalol, it is recommended that you first consult with your doctor, as the drug is addictive and addictive.
Tablets are easy to carry
Is it possible to drink Corvalol drops with hypertension?
Corvalol tincture is often taken by hypertensive patients, noting the hypotensive effect of the drug. Moreover, hypertension is also listed in the indications for use given in the instructions for the drug. Nevertheless, Corvalol should be taken with caution for the treatment of hypertension. The drug is addictive and can cause deterioration of the cardiovascular system when the drops are abused.
You can take Corvalol at high blood pressure, as it lowers blood pressure due to its antispasmodic effect. However, this remedy should act as an auxiliary medicine. Drops do not cure hypertension. You can take them to quickly normalize the psycho-emotional state in order to avoid a sudden jump in pressure. Also, hypertensive patients can occasionally take drops to relieve headaches provoked by increased pressure.
In hypertensive patients, blood pressure often rises due to experiences - sedative drops will help to avoid this
What happens if you drink Corvalol at low pressure?
Corvalol does not increase pressure, but lowers it, as it has an antispasmodic effect and relaxes blood vessels. With hypotension, taking medication can make you feel worse.
In the case of a slight decrease in pressure, taking Corvalol is justified only to normalize sleep. The tool relieves tension and irritability and helps to normalize sleep. As practice shows, taking drops or tablets with phenobarbital at low pressure can induce sleep for up to 15 hours.
Hypotonic patients often note a breakdown and apathy. This is due to impaired blood circulation and oxygen transport to the brain cells. At very low pressure, Corvalol can only aggravate the condition. There is severe weakness, dizziness, the patient may faint.
Pressure below 100 to 60 mm Hg. - an absolute contraindication to taking these sedative drops.
Contraindications
The drug should not be taken in the following cases:
- severe hypotension;
- severe disorders in the liver and kidneys;
- individual intolerance;
- hypersensitivity to bromine;
- heart failure;
- myocardial infarction;
- diabetes;
- depression;
- alcoholism or drug addiction;
- dependence on medications;
- pronounced shortness of breath.
Phenobarbital disrupts the action of hypoglycemic drugs and insulin, therefore it is prohibited for diabetics. Taking Corvalol in this case can lead to the development of hypoglycemia.
Side effects
Subject to the recommended dosage, Corvalol is well tolerated by the body. At the same time, Corvalol lowers blood pressure, so taking the drug at low and low pressure in patients with hypotension can lead to serious consequences, up to coma.
The most common side effects:
- dyspnea;
- stomachache;
- pressure reduction;
- bradycardia;
- inhibition of the reaction;
- apathy;
- prostration;
- nausea and vomiting.
Valerian extract in the composition of Corvalol tincture can cause allergies. In case of intolerance, severe symptoms of an allergic reaction may appear, up to angioedema. In this case, you need to urgently call an ambulance.
In case of severe manifestations of side effects or an overdose, you need to call an ambulance
Overdose symptoms
An overdose of Corvalol is observed while taking large doses of the drug. This is manifested by a decrease in pressure to critical values, confusion, disorientation. Syncope may develop. In severe cases, an overdose of Corvalol can cause respiratory arrest.
Long-term use of the drug causes bromine poisoning. Corvalol is addictive. Abrupt withdrawal of the drug with prolonged use causes withdrawal symptoms. Against the background of discontinuation of the drug, psychomotor agitation is often observed.
An overdose of Corvalol requires immediate symptomatic treatment. In severe cases, resuscitation is necessary.
Use for pregnant women and children
Corvalol is not used during pregnancy. The drug contains a narcotic substance that can cause the development of various disorders in the fetus. Corvalol during pregnancy can also provoke a miscarriage.
The drug passes into breast milk, so it is forbidden to use it during lactation. The effect of Corvalol on newborns is manifested in severe form. This medicine can cause the baby to stop breathing and develop a coma. Corvalol children, regardless of age, should not be taken.
Drug Interactions and Precautions
The action of Corvalol is based on the effect on the nervous system, so the drug should not be taken with other sedatives and tonics, including caffeine. The drug enhances the effect of painkillers and anesthetics. Corvalol should not be taken concomitantly with epilepsy drugs.
Many are interested in what will happen if you drink Corvalol and alcohol. This combination can cause symptoms of alcohol intoxication and severe liver dysfunction, so alcohol is prohibited while taking drops or tablets.
During treatment with the drug, you should refuse to drive vehicles, as the drug affects the reaction rate.
Neurotic conditions, insomnia and other disorders require immediate medical attention. As a rule, in such diseases, patients are prescribed vasodilators and the most popular and inexpensive drugs include the well-known drug Corvalol. Instructions for use, reviews of the drug will be discussed below.
Form, description of the drug, composition and packaging
In what form is the drug "Corvalol" produced? Consumer reviews report that this tool can be purchased in two forms:
- Drops are transparent with a characteristic odor for oral administration. They include ethyl ester of alphabromisiovaleric acid, phenobarbital and pepper. Such a tool is produced in dark glass bottles.
- "Corvalol" in tablets. The reviews say that the active ingredients of this form are peppermint oil, ethyl ester of α-bromoisovaleric acid and phenobarbital. As additional substances, beta-cyclodextrin, potato starch, lactose monohydrate, microcrystalline cellulose and magnesium stearate are used. Tablets have a round and flat shape, bevelled edges, as well as white color with splashes. They go on sale in cell packs.
Pharmacological characteristics
What is the drug "Corvalol"? Reviews of experts indicate that this is a combined remedy, the action of which is due to the properties of the ingredients that make up its composition.
This medicine has an antispasmodic and sedative effect. In addition, it facilitates the onset of sleep.
Drug properties
What properties are inherent in drops and tablets "Corvalol"? Reviews of doctors claim that the effectiveness of this remedy has been confirmed by many years of experience.
Ethyl bromisovalerianate, or the so-called ethyl alpha-bromisovaleric acid ester, has a sedative (similar to valerian) and antispasmodic effect, which is due to irritation of the nasopharynx and oral cavity receptors, as well as a decrease in reflex excitability in the central nervous system and increased inhibition in the neurons of the subcortical structures and the cerebral cortex . In addition, the medication in question reduces the activity of the vasomotor central centers and has a local antispasmodic effect (mainly on smooth muscles).
Such a component of the drug as phenobarbital enhances the sedative effect of other substances, facilitates the onset of sleep and reduces the excitation of the central nervous system.
As for peppermint oil, it has antispasmodic, vasodilating (reflex), antiseptic and choleretic effects. It is able to irritate the cold receptors of the oral mucosa and reflexively dilate the vessels of the brain and heart. In addition, this component eliminates signs of flatulence (due to irritation of the receptors of the gastrointestinal mucosa) and enhances intestinal motility.
Indications
What is the drug "Corvalol" prescribed for? Reviews report that this remedy is used as a vasodilator and sedative for diseases such as:
It should also be said that Corvalol is used as an antispasmodic for spasms of the muscles of the digestive tract (for example, with biliary or intestinal colic).
Contraindications
Like any medicine, Corvalol also has contraindications. These include:
- hypersensitivity to drug substances;
- severe disorders of the kidneys and liver;
- breastfeeding (if it is necessary to use the drug during breastfeeding, it is necessary to decide on the termination of lactation);
- lactase deficiency;
- period of pregnancy;
- minor age (safety and effectiveness have not been established);
- lactose intolerance;
- malabsorption glucose-galactose (since the drug contains lactose).
The drug "Corvalol": instructions for use (tablets)
Reviews of experts report that you can take this medication without a doctor's prescription. The dosage of the drug is selected individually.
The medication is taken orally before meals with water. For adults, the drug is prescribed 1-2 tablets twice a day. With tachycardia, a single dosage can be increased to three tablets per day. The maximum allowable dose is 6 tablets.
The duration of the medication is set individually, depending on the patient's condition.
How are Corvalol drops (tincture) taken?
The reviews say that the drug in the form of drops must be taken orally before meals. The drug is prescribed in the amount of 15-30 drops. They are dissolved in a small volume of drinking water (about 30-50 ml) twice or thrice a day.
If necessary, a single dosage of the drug (for example, with tachycardia) can be increased to 40-50 drops.
As for children, depending on the clinical picture of the disease and age, they are prescribed 3-15 drops per day.
The duration of the drug in children is set individually.
Does it cure herpes and acne?
Does Corvalol help with herpes? Reviews of supporters of traditional medicine say that when the first signs of this disease appear (for example, discomfort, twitching of the lips and itching), a cotton swab is soaked in a medicine, and then pressed against the sore spot for a few seconds. With the timely implementation of this procedure, herpetic eruptions do not appear.
It should also be noted that the medicine in question also treats bubbles that have already appeared. They are lubricated with the drug until the wounds disappear.
Does Corvalol help with acne? Consumer reviews say that this medication effectively copes with acne. They are treated in exactly the same way as herpes.
Side effects
Tablets and drops "Corvalol" often cause drowsiness, decreased concentration, slow heart rate, dizziness and allergic reactions. Also, against the background of taking this remedy, patients may experience disorders of the digestive tract.
Usually, all of these side effects go away on their own with a decrease in the dosage of the drug or discontinuation of its intake.
With prolonged use of the drug, drug dependence, addiction, withdrawal syndrome, as well as bromism and accumulation of bromine in the body may develop.
There is no experience with the use of this drug in children under 18 years of age. Therefore, minors are not allowed to take it.
During the use of the drug, you should not drink alcoholic beverages. It is also required to refrain from engaging in hazardous activities that require a person to react quickly and increase concentration (including when working with complex mechanisms and driving vehicles).
Similar means and cost of medicine
The price of Corvalol is the lowest among products with a similar effect. You can buy a bottle of drops or tablets for 15-20 rubles. It is the low cost of the drug that contributes to its particular popularity among patients.
What can replace this remedy if there are contraindications? According to information from experts, this drug has many analogues. The closest in properties include the following: "Cardiolin", "Pumpan", "Aspirin Cardio", "Neocardil", "Captopres", "Nicotinic acid", "Inosine", "Sotaleks" and others. It should immediately be noted that the effectiveness of these funds and their method of administration may differ significantly from the same indicators of the Corvalol drug. Therefore, only an experienced specialist should replace the mentioned medicine with the listed medicines. Moreover, most of them are forbidden to be given to young children.
Medical and consumer reviews
What do patients say about Corvalol? Feedback from most consumers is positive. They claim that this medication quickly eliminates irritability, restores heart function and helps to normalize sleep. Moreover, many patients choose this tool because it not only effectively copes with the tasks, but also has a very low cost.
However, it should be noted that, in addition to positive reviews, the medication in question also has negative feedback. According to doctors, Corvalol drops and tablets are ineffective compared to their counterparts. This medicine has a sedative and antispasmodic effect only for a short period of time. After stopping the medication, feeling unwell often returns.
No side effects were reported by users while taking this drug.
The components that make up Corvalol eliminate disorders of the human nervous system. They also facilitate the process of natural falling asleep. And even help with some heart diseases.
Release form and composition
The company that manufactures Corvalol produces drops in black glass with a volume of less than 50 ml. Also, the tool is sold in tablets, which are stored in plates. One contains 10 pieces.
The medicine contains the following elements:
Active substances: phenobarbital - 18.26 mg, ethyl ester of alpha-bromisovaleric acid - 20 mg;
Auxiliary components: peppermint oil, ethanol 95%, artesian water, sodium hydroxide.
The principle of action of Corvalol
Helps in cases of spreading spasm and irritability.
The elements contained in the medication perform the functions of calming:
- Phenobarbital. Nerve impulses stop flowing to the brain. Vital energy gradually decreases, reactions become more passive. Within a short period of time, the process of calming down begins. The pressure is reduced, but does not relieve the symptoms of hypertension. This component reduces the level of bilirubin and helps with Gilbert's syndrome;
- Mint oil. Expands blood vessels, fights bloating. When used, a minty taste is felt;
- Ethyl ester of "alpha-bromoisovaleric acid". Excitation processes stop, calming gradually occurs. The “braking” of the personality begins.
Indications for use
Assign to reduce nervousness. Helps with the action of negative emotions and poor natural falling asleep. The use of Corvalol is effective against the manifestations of hypertension, with pain in the stomach and intestines.
Contraindications
Instructions for use Corvalol
If there was an increase in heart rate - three times a day. For serious illnesses - increase to six doses.
If you use a medication, and after alcohol, the effect of Corvalol will not occur.
On the contrary, there is an acceleration of the heart rate from alcohol and a decrease from the drug. The first is removed quickly enough and there is a sharp contraction of blood vessels.
Overdose in most cases leads to serious consequences. Ranging from inflammatory skin lesions to unstable heart function. As a result, the internal organs do not receive enough oxygen and the necessary vital substances. There is depression, neuropsychiatric disorders. And then death may follow. Drink Corvalol considering contraindications.
Side effects
Well tolerated by patients, if you follow the rules of use and do not increase the dose. In the case when a person has a high sensitivity to the drug, then the following symptoms are possible - vomiting, indigestion, dizziness.
In the worst cases, there are spasms of the limbs, exhaustion, lethargy. Also, there is a decrease in the pulse rate and heart beats gradually decrease.
Corvalol during pregnancy
Women in position may experience sleep disturbances. There may be increased anxiety. Hormonal disorders during fetal development are a common symptom. The use of Corvalol can be dangerous for a child because of one component - phenobarbital. Therefore, it is better not to take the remedy.
Specialists in pharmacology have studied that frequent use of the drug is very bad for the mother and fetus. Substances enter the stomach and therefore the child also receives them.
If you wake up in the middle of the night due to lack of air and cannot cope without the help of medicines, then it is better to take valerian and validol. They can get rid of the symptoms. But, if dependence on the drug is manifested, then it is better to use panangin and verapamil. They contain elements that do not harm the health of mother and child.
The constant use of the drug threatens with serious consequences, because chemical compounds are harmful.
Before deciding to take any drug, it is recommended to consult with a gynecologist.
Medicine analogs
Many analogues of the drug appeared on sale. Pharmacological studies have identified similar medicines that are not inferior to Corvalol in terms of functionality. It does not contain harmful substances.
Valerian- reduces nervousness, dilates coronary vessels, reduces the number of heart beats, a person falls asleep easily. The components of the drug enhance the effect of the drugs taken for spasm and for sedation.
Valocordin- removes the symptoms of tachycardia, high irritability and fear. Eliminates sleep problems.
Verapamil- from abruptly arising angina pectoris and fluctuations in heart beats, arrhythmias.
Barboval- relieves neurosis, excitability, insomnia, hysteria. Take with mild attacks of angina pectoris, spasms of the stomach and intestines.
Corvaldin- helps with fear, agitation, disorders of the nervous system, anxiety, facilitates falling asleep. The components included in the medication are very well tolerated. Harmless to the heart, even if it functions in a bad rhythm. The number of strokes gradually decreases and eventually returns to normal.
Corvaltab- eliminates high nervousness. Doctors can prescribe for insomnia. Prevents disorders of the cardiovascular system, spasms, the initial stages of a sharp increase and decrease in pressure.
Motherwort tincture- a sedative, normalizes the heartbeat. Eliminates harmful substances, inflammation. Acts as a mild diuretic.
Corvalol is used in the following cases:
- insomnia and neuroses with high irritability;
- in the complex of hypertension and vegetovascular dystonia;
- with not strong spasms of the coronary vessels;
- in case of tachycardia;
- as an antispasmodic drug to relieve intestinal spasm caused by neurovegetative disorders.
How to use
For adults, Corvalol is prescribed orally or sublingually, 1 tablet or diluted with water, 10-30 drops. Can be consumed on a piece of sugar 2 or 3 times a day.
The drug is taken as needed, for example, with tachycardia and during spasms of the coronary vessels. A single dose can be increased to 3 tablets or 45-50 drops.
The period of application of Corvalol is determined by the doctor, based on the data of the clinical effect and individual tolerance to the drug (Reviews about Corvalol can be read at the end of the article).
Release form. Compound
Corvalol is available in the form of tablets No. 10, 30, 50 pcs.
The composition of the tablets:
- ethyl ester of alphabromisiovaleric acid - 12, 42 mg;
- phenobarbital - 11.34 mg;
- mint oil - 0.88 mg.
The release of Corvalol is also made in the form of drops:
- d/peroral. approx. fl. 25 ml, in a pack, No. 1
- d/peroral. approx. fl. 50 ml, in a pack, No. 1
The composition of the drops:
- ethyl ester of alphabromisiovaleric acid - 2%;
- phenobarbital - 1.82%;
- peppermint oil - 0.14%.
Auxiliary components:
- sodium hydroxide;
- ethyl alcohol 90%;
- distilled water.
Beneficial features
Corvalol is a sedative and antispasmodic drug, the effect of which is determined by the components present in it.
- The ethyl ester of α-bromoisovaleric acid is characterized by a reflex-soothing and antispasmodic effect on the body due to irritation of the receptors of the oral cavity and nasopharynx, as well as a decrease in excitability in the central nervous system. In this case, there is an increase in the phenomena of inhibition in the brain, as well as a decrease in the activity of vasomotor centers and a direct local antispasmodic effect on the smooth muscles of all vessels.
- The phenobarbital component is able to reduce the flow of excitation to the cerebral cortex and subcortical structures. Depending on the dose, the decrease in the activating effect has a hypnotic, sedative and tranquilizing effect.
- Corvalol reduces excitatory effects on vasomotor centers, peripheral and coronary vessels, lowering the total blood pressure, thereby relieving and preventing vasospasm, especially cardiac.
- Peppermint oil contains many essential oils: about 50% menthol and 5–9% of its esters. They irritate the "cold" receptors of the oral cavity and reflexively dilate the vessels of the brain and heart, eliminating spasm of smooth muscles. Able to cause a sedative and weak choleretic effect. Peppermint oil also has an antispasmodic and antiseptic effect, and also has the ability to eliminate the phenomenon of flatulence.
Taking Corvalol sublingually, its absorption begins in the sublingual region. The bioavailability of active substances is high - up to 80%. The positive effect appears almost immediately.
The effect of the drug when taken orally develops after 10-30 minutes and lasts up to 6 hours. In those who have previously taken barbituric acid preparations, the duration of action becomes shorter due to an increase in the rate of metabolism of phenobarbital in the liver.
In elderly people and patients with cirrhosis of the liver, Corvalol's metabolism function is reduced, so T ½ becomes longer, which requires a dose reduction and an increase in the time interval between taking the drug.
Video
Watch the video below about Corvalol:
Side effects
In most cases, the drug is well tolerated. In rare cases, the following side effects may occur:
All these phenomena are gradually eliminated as the dosage of the drug is reduced. Dependence on Corvalol is possible in the case of its prolonged use, and bromism phenomena are also possible. The main symptoms include: apathy, depression, rhinitis, depression of the central nervous system, conjunctivitis, poor coordination, acne, confusion, hemorrhagic diathesis.
Contraindications
- high sensitivity to the constituent components of the drug, as well as bromine;
- violations of the functions of the liver and kidneys;
- hepatic porphyria;
- severe heart failure;
- the period of bearing a child and breastfeeding.
The drug should not be taken when operating mechanisms and drivers of motor vehicles.
There is no experience of using Corvalol in childhood.
Interaction with other drugs
- enhance the action of Corvalol drugs of depressant central action;
- phenobarbital may have an inducing effect on liver enzymes, therefore, its simultaneous use with drugs metabolized in the liver (oral contraceptives, griseofulvins, drugs with coumarin derivatives, corticosteroids) is not recommended;
- Corvalol is able to enhance the effect of local anesthetics, hypnotics and painkillers (this is due to the derivatives of barbituric acid contained in it);
- in combination with valproic acid, its effect is enhanced;
- together with methotrexate, its toxicity increases;
- alcohol increases the toxicity of the drug and enhances the effect of exposure.
Overdose
Overdose is possible in the case of frequent and prolonged use of the drug, which is associated with the process of cumulation of its components. Quite a long and constant use can provoke dependence, psychomotor agitation and withdrawal symptoms. A sharp refusal to take Corvalol can provoke a withdrawal syndrome.