Mifepristone INN
International name: Mifepristone
Dosage form: tablets
Pharmachologic effect:
Synthetic steroid antiprogestogen (blocks the action of progesterone at the level of progestogen receptors), does not have progestogenic activity. Marked antagonism with GCS. Depending on the phase of the menstrual cycle, it causes an increase in the contractility of the myometrium, stimulating the release of interleukin-8 in choriodecidual cells, increasing the sensitivity of the myometrium to Pg (to enhance the effect, it is used in combination with a synthetic analogue of Pg), resulting in desquamation of the decidua and excretion of the ovum ; causes inhibition of ovulation, changes in the endometrium and prevents the implantation of a fertilized egg.
Pharmacokinetics:
Absolute bioavailability - 69%. After a single oral dose of 600 mg Cmax - 1.98 mg / l, TCmax - 1.3 hours. Communication with proteins (albumin and acid alpha1-glycoprotein) - 98%. After the distribution phase, excretion is slow at first, the concentration decreases by a factor of 2 between 12-72 hours, then more rapidly. T1 / 2 - 18 hours
Indications:
Termination of uterine pregnancy early (up to 42 days of amenorrhea). Preparation and induction of labor in full-term pregnancy. Emergency (postcoital) contraception within 72 hours after intercourse without the use of contraceptives or methods, or if they are unsuccessful (including an error in the application of the calendar method, unsuccessful interruption of sexual intercourse, rupture or slipping of the condom) - 10 mg tablets .
Contraindications:
Hypersensitivity, adrenal insufficiency and long-term corticosteroid therapy, acute or chronic renal and / or hepatic insufficiency, porphyria, anemia, hemostasis disorders (including previous treatment with anticoagulants), inflammatory diseases of the female genital organs, the presence of severe extragenital pathology, smoking women over 35 years of age (without prior consultation with a therapist). For termination of pregnancy: suspected ectopic pregnancy, pregnancy not confirmed by clinical studies, exceeding 42 days after the cessation of menstruation, which occurred against the background of the use of IUDs or after the abolition of hormonal contraception. For the preparation and induction of labor: severe preeclampsia, preeclampsia, eclampsia, premature or post-term pregnancy. With caution. COPD (including bronchial asthma), arterial hypertension, arrhythmia, CHF.
Dosing regimen:
For medical termination of pregnancy: a single dose of 600 mg of mifepristone is taken orally in the presence of a doctor, 1-1.5 hours after a meal (light breakfast), washed down with 1/2 cup of boiled water. In order to enhance the effect of mifepristone, a synthetic analogue of PgE1 is prescribed - 400 mg of misoprostol. The patient should be under the supervision of medical personnel for at least 2 hours after application. 36-48 hours after taking mifepristone, the patient should come for ultrasound control. After 8-14 days, a clinical examination and ultrasound control are repeated, and the level of beta-CHG is determined to confirm that a miscarriage has occurred. If there is no effect from the use of the drug on day 14 (incomplete abortion or ongoing pregnancy), vacuum aspiration is performed, followed by a histological examination of the aspirate. For preparation and induction of labor: a single dose of mifepristone 200 mg orally in the presence of a physician. After 24 hours, a second dose of 200 mg. After 48-72 hours, the state of the birth canal is assessed and, if necessary, Pg or oxytocin is prescribed. For contraceptive purposes: inside, 2 hours before or 2 hours after a meal, within 72 hours after unprotected intercourse, 1 tablet (10 mg) in any phase of the menstrual cycle.
Side effects:
Metrorrhagia, lochiometer, subinvolution of the uterus, discomfort and pain in the lower abdomen; exacerbation of infections of the uterus and urinary tract; weakness, headache, nausea, vomiting, diarrhea, dizziness, hyperthermia, chills. Against the background of combined treatment with misoprostol (additionally): vaginitis, dyspepsia, insomnia, asthenia, leg pain, anxiety, anemia, decrease in Hb (more than 2 g / dl), fainting, leucorrhea. Overdose. Symptoms: adrenal insufficiency.
Special instructions:
To interrupt pregnancy, the drug should be used only in medical obstetric and gynecological institutions belonging to the public health system, as well as in municipal and private property, having licenses for this type of activity and appropriately trained medical personnel and the necessary equipment. Patients are informed that in case of failure of therapy on days 10-14 (incomplete abortion or ongoing pregnancy), the pregnancy will need to be terminated surgically (the possibility of congenital malformations in the fetus). Breastfeeding is stopped for 14 days after ingestion. The use of the drug requires the prevention of Rh alloimmunization and other general measures associated with abortion. Patients with prosthetic heart valves or infective endocarditis treated with mifepristone should be treated prophylactically with antibiotics. The drug is not recommended as a planned permanent contraception; does not protect against sexually transmitted diseases and AIDS.
Latin name: Mifepristone
ATX code: G03XB01
Active substance: Mifepristone
Manufacturer: Pharmsintez, Russia
Pharmacy leave condition: On prescription
Mifepristone is a hormonal drug used to terminate a pregnancy up to 41 days. menstrual cycle, as well as to stimulate labor.
Indications for use
- When terminating a pregnancy for up to 9 weeks using artificial prostaglandin analogues
- For conservative expansion of the walls of the cervix (termination of pregnancy before 12 weeks in an operative way)
- In order to potentiate the effects of prostaglandins in late pregnancy (at 13-22 weeks for medical reasons only)
- For the implementation of stimulation of labor activity in case of fetal death at a later date (2-3 trimester).
Compound
One tablet of a hormonal drug contains mifepristone 200 mg. In this preparation there are additional components, among them include:
- Starch
- magnesium stearate
- lactose
- Carboxymethyl starch
- Cellulose in microcrystalline form
- Polyvinylpyrrolidone.
Medicinal properties
Mifepristone tablets are classified as synthetic antiprogestogens, under the influence of the tablets, the process of active influence on the contractility of the uterus begins. The action of Mifepristone is aimed at increasing the tone of the uterus, as well as the contractile activity of its muscle layer, namely the myometrium. After taking the active substance of the tablets, it neutralizes the effect of the hormone progesterone on the receptors. It does not show gestagenic activity, it works as an antagonist of GCS, since competition is observed when communicating with receptors.
After taking the hormone, an increase in the frequency of contractions of the myometrium begins, this occurs due to a specific action (stimulation of a substance inside the choriodecidual cells, namely interleukin-8). This increases the sensitivity of the myometrium to how prostaglandins act. Taking a regular hormonal drug in the amount prescribed by the doctor, they start stimulating the excretion of the fetal egg, this will happen when the decidua is desquamated.
After a woman takes a dosage of 600 mg of the drug, the highest concentration of the active ingredient is observed no later than 1.3 hours. The bioavailability of mifepristone is 69%. Communication with albumins is observed at the level of 98%.
The half-life of the substance does not exceed 18 hours. The active ingredient contained in the tablets is excreted no faster than 12 hours, the plasma index decreases by 2 times. After this, the second phase of elimination begins, which proceeds quite quickly.
Release form
Price from 4000 to 5000 rubles.
Domestic mifepristone is available in the form of yellowish tablets. The polymer jars contain 3 or 6 pcs., It is sold together with the instructions for Mifepristone.
Mifepristone: instructions for use
The attending physician will tell you how to take Mifepristone, the first tablet of the drug is taken in the conditions of medical institutions, where the patient's condition is monitored.
According to the instructions to drink Mifepristone in the first weeks of pregnancy, in order to stimulate uterine contraction, it is necessary to take 600 mg of drugs (number of tablets - 3 pcs.). You will need to take the pill in the presence of a doctor 1-1.5 hours after the main meal, drinking a sufficient amount of liquid. How long the drug works and what happens after taking it is best to check with a gynecologist. Medical abortion occurs after taking mifepristone for 24-48 hours, when blood begins to be released from the genital tract with the separation of clots. After how many hours the bleeding will end and what consequences the woman expects after such a procedure, the doctor will tell in detail. In some cases, the specialist will recommend using other hormonal pills that cause labor pains, for example, Pencrofton. Before using Pencrofton, it is recommended to clarify how it is drunk and how effective it will be.
The doctor who terminated the pregnancy should follow the patient for 2 hours to assess how the pills will begin to work. After 36-48 hours after taking mifepristone tablets, the woman will need to undergo an ultrasound examination to make sure the drug is working. This procedure is mandatory. If the pills did not work as expected, and the contractile activity of the uterus, causing a miscarriage, did not begin, misoprostol is prescribed. This drug will help induce contractions, artificial labor will begin.
After the discharge of the fetal egg has been stimulated (in a week or after 14 days), it is necessary to repeat the ultrasound.
If a woman taking this drug has an incomplete abortion or the pregnancy is not terminated, it is recommended to perform a vacuum aspiration with further examination of the resulting aspirate.
Use in term pregnancy
I drink the drug and before childbirth with a full-term baby, Mifepristone causes labor pains. This action can prevent complications that are characteristic of the late birth period. Stimulation of delivery on Mifepristone involves taking 200 mg of a hormonal drug (1 tablet once a day). After 24 hours, the hormonal effect of this drug is continued, the tablets are taken in the same way as the woman drank them before. At the end of the third day, the state of the birth canal is assessed, the heartbeat and activity of the child is monitored. After how much the drug Mifepristone begins to act in a particular case, you should ask your doctor.
If, according to the results of the examination, it turned out that the pills did not cause uterine contractions and the woman is not in childbirth, other drugs are prescribed for admission - Oxytocin or prostaglandins. Against the background of these drugs, contractions begin, there is no need to carry out any other stimulating actions for the woman to give birth on her own.
It is also important how mifepristone acts on the fetus. Artificially induced childbirth after taking doses of a hormonal drug prescribed by a doctor in most cases does not lead to serious consequences; a slowdown in psychomotor reactions is not recorded in children. But still, Mifepristone is prescribed to stimulate labor in late pregnancy in exceptional cases, in order to prevent possible side effects for the mother's body and pathology in the child (usually they are recorded after women have given birth). In some cases, it will be safer to give birth without taking any hormonal labor stimulants.
Application during GV
Not prescribed during lactation.
Contraindications
- The presence of uterine fibroids
- Serious pathologies of the functioning of the adrenal glands, liver and renal system
- Severe anemia
- High risk of ectopic pregnancy
- porfiria
- The course of inflammatory diseases of the internal genital organs
- Premature or very postterm pregnancy
- Pregnancy that occurred while taking hormonal contraceptives
- In late pregnancy
- The presence of preeclampsia
- Excessive susceptibility to a hormonal drug
- Violation of hemostasis
- Pregnancy for more than 42 days. after the last menstruation
- Abnormal location of the fetus
- Absence of confirmation of pregnancy on ultrasound
- Identification of extragenital pathologies
- Bloody discharge began to appear during pregnancy (their etiology has not been established).
Precautionary measures
With caution, a remedy is prescribed for confirmed arrhythmias, arterial hypertension, and also for bronchial asthma.
To drink the drug or not in the presence of some complications is determined individually.
Cross-drug interactions
When taking Mifepristone along with GCS, the dosage of the latter will need to be increased.
Non-steroidal anti-inflammatory drugs, including aspirin, should not be used, in this case it will be possible to prevent a decrease in the effectiveness of the treatment.
Side effects
In a number of cases, adverse reactions caused by mifepristone are noted:
- Severe headaches along with dizziness
- Asthenia
- Nervous excitement and excessive anxiety
- Development of anemia
- Fever, lethargy
- Vomit
- Pain in the lower abdomen
- Exacerbation of infectious diseases of the genitourinary system
- Dyspepsia
- The occurrence of vaginitis, the appearance of leucorrhoea
- Sleep quality disorder.
If the above adverse reactions are observed, do not take hormonal pills and seek medical help.
Overdose
An overdose of mifepristone tablets when taking less than 2 g per day is unlikely. In the case of an overdose, adrenal insufficiency develops.
Storage conditions and shelf life
Hormonal drugs must be stored in a dark, preferably cool place at temperatures up to 25 C for 2 years from the date of manufacture.
Analogues
Mir-pharma, Russia
Price from 5889 to 6409 rubles.
The composition of Ginestril completely coincides with Mifepristone, respectively, and it has the same effect on the body. In addition, both drugs are from a domestic manufacturer. Gynestril is produced in the form of tablets, one pack contains 30 pcs. dosage of 50 mg.
Pros:
- May be used in the treatment of uterine leiomyoma
- Emergency contraceptive drug
- The shelf life of Ginestril tablets is 5 years.
Minuses:
- The high price of Gynestril
- Not indicated for ovarian tumors
- Ginestril is available by prescription.
Misoprostol and mifepristone are used in combination for early medical abortion without surgery. Mifepristone and misoprostol must be taken together and should only be taken if the pregnancy is less than 9 weeks.
The use of drugs must be done correctly. At the first stage, you need to take Mifepristone tablets. Doses are prescribed by the attending physician. The drug causes the endometrium and placenta to separate. In this case, the cervix softens and its contractions increase. This is necessary to remove the fetus.
Then you need to take misoprostol tablets, which the doctor prescribes to use every 2 days after the use of mifepristone, after which the uterine contractions increase and a miscarriage occurs. You need to know that in some clinics, women are left for 4 hours after taking misoprostol. This is done due to the fact that when using the medication, various side effects may occur. Termination of pregnancy usually occurs at home or in a hospital setting. Doctors sometimes allow women to use misopristol at home.
How should medicines be taken?
A medical-type abortion can be done in 2 or more visits to your doctor. To properly use these medicines, a woman must go to see a gynecologist. At the first visit, doctors give the patient Mifepristone, and the second medicine for use is given to the woman at home.
After 14 days, the patient goes to the doctor again. An examination is carried out, which should establish that the termination of pregnancy occurred without any complications.
If the medicines do not work, then the patient is sent for a surgical operation to complete the process, since misoprostol causes damage to the fetus and it becomes incapacitated. During the procedures, a woman can use various painkillers.
The effectiveness of this method of abortion
Medical abortion is performed up to 9 weeks of gestation. If this time does not exceed 49 days, then the effectiveness of the combination of drugs is 91-93%. If the gestational age is more than 7 weeks, then the quality of medical abortion decreases. It should be noted that after the use of misoprostol, many patients may experience bleeding for 4 hours and the uterus begins to contract. Usually, the process of terminating a pregnancy ends one day after doctors give the woman misoprostol. If this does not happen, then a second dose of the drug can be used. If this does not help, then you need to do a surgical operation.
Side effects and various complications
For the drug Misoprostol, the instructions for use indicate the possibility of the following adverse events:
- The patient experiences nausea, which then turns into vomiting.
- Symptoms of diarrhea may appear.
- Often women complain of headaches and severe dizziness.
- Hot flushes may begin or, conversely, the patient feels chills.
- Some women feel tired or tremble.
The longer the pregnancy, the higher the risk of the above side effects. This is especially true in women with their first pregnancy.
There may be a fatal outcome if the patient after a medical abortion undergoes a severe infection. In this case, the patient is tormented by nausea, she weakens, diarrhea appears, sometimes there are pains in the abdomen. If a woman has these symptoms immediately after a medical-type abortion, she should immediately consult a doctor.
Complications, after which the patient should go to the gynecologist, may have the following symptoms:
- There was severe bleeding, during which large clots come out of the woman for 2 or more hours.
- The outflowing blood spoils 2 large pads in 60 minutes, and the bleeding itself lasts more than 2 hours.
- Bleeding continues continuously for half a day.
- The woman showed signs of infection: pain in the head or muscle tissue, deterioration of health, severe dizziness. Body temperature may be normal.
- Pain in the abdomen that does not go away even after using analgesics, prolonged rest, or using a heating pad.
- Hot flashes have appeared or the body temperature has become above 38 ° C and does not subside for more than 4 hours.
- Vomiting that lasts more than 240 minutes.
- The stomach swells or the heart beats faster.
- Vaginal discharge appeared, which has a very bad smell.
- Swollen, sore and reddened genitals.
- Bleeding does not stop for more than 2 weeks.
- There were side effects after the procedure.
- No period for 42 days.
- A woman has depression after a medical abortion.
When should drugs not be used?
Mifepristone is not recommended for patients who:
- Ectopic pregnancy.
- Various neoplasms in the ovaries.
- There is a spiral inside the uterus.
- The patient underwent long-term treatment with corticosteroids.
- Dysfunction of adrenal structures.
- During advanced anemia.
- The patient is on anticoagulants or has poor blood clotting.
- Diagnosed with liver and kidney disease.
- There is hypertension or myocardial disease.
- SARS.
- There is an allergy to the components of the drug.
- There are skin diseases that are inherited.
In medical-type abortion procedures, the patient should not take aspirin or drink alcoholic beverages.
A woman should not have sex for 7 days after the procedures (the attending physician will indicate the exact time of abstinence to her).
After that, she should use condoms and contraceptives (for example, a spiral) during sexual intercourse so as not to introduce an infection into the body.
Mifepristone is a hormonal drug, an antiprogestogenic steroid of synthetic origin. It is used for medical termination of pregnancy in the early stages.
The action of the drug lies in the ability to stimulate the tone of the uterus and the contractile activity of the myometrium. It is a blocker of progesterone receptors (pregnancy hormone), which subsequently leads to the destruction of the membrane of the fetal egg and miscarriage.
It does not have gestagenic activity, antagonism with GCS is noted.
The drug reaches its maximum concentration in the blood serum after a single oral dose of 600 mg after 1.3 hours. C max is 1.98 mg/l. The absolute bioavailability of Mifepristone is 69%. 98% binds to plasma proteins (albumin and α1-glycoproteins).
The half-life of the drug is 18 hours. This process takes place in two phases: the slow elimination phase (12-72 hours), in which the concentration of the active component in the blood plasma is reduced by 2 times, and then the rapid elimination phase.
Indications for use
What helps mifepristone? According to the instructions, the drug is prescribed in the following cases:
- Artificial stimulation of the onset of the birth process during full-term pregnancy;
- Termination of uterine pregnancy in the early stages (up to 42 days without menstruation).
Instructions for use Mifepristone, dosage
The drug should be used only in specialized institutions with the necessary equipment.
For medical termination of pregnancy in the early stages, Mifepristone is prescribed at a dose of 600 mg (3 tablets) once. In the presence of a doctor, it is taken orally 1-1.5 hours after a meal (light breakfast), drinking 100 ml of pure water.
The patient should be observed for at least 2 hours after taking the drug. After 36-48 hours after admission, the patient should report to the hospital for ultrasound control and, if necessary, she should be prescribed misoprostol.
After 10-14 days, a clinical examination and ultrasound control are repeated, if necessary, the level of chorionic gonadotropin is determined to confirm spontaneous abortion.
If there is no effect from the use of the drug on day 14 (incomplete abortion or ongoing pregnancy), vacuum aspiration is performed, followed by a histological examination of the aspirate.
To induce labor
In full-term pregnancy, mifepristone is prescribed 1 time per day at a dosage of 200 mg (1 tablet). According to the instructions for use, after 24 hours, a second dose is taken in the same dosage.
Assessment of the state of the birth canal is carried out after 2-3 days, after which (if necessary) oxytocin or prostaglandins are prescribed.
Postcoital contraception: inside at a dose of 10 mg (regardless of the phase of the menstrual cycle), 2 hours before or 2 hours after a meal (within the next 72 hours after unprotected sexual intercourse).
Leiomyoma of the uterus: inside at a dose of 50 mg 1 time / day, the duration of treatment is 3 months.
Side effects
The instruction warns of the possibility of developing the following side effects when prescribing Mifepristone:
- From the digestive system: nausea, vomiting, diarrhea.
- From the side of the central nervous system: dizziness, headache.
- On the part of the reproductive system: spotting from the genital tract, menstrual irregularities, amenorrhea, exacerbation of inflammation of the uterus and appendages, lochiometer, subinvolution of the uterus.
- Allergic reactions: urticaria.
- Other: discomfort and pain in the lower abdomen, weakness, hyperthermia.
Contraindications
Mifepristone is contraindicated in the following cases:
- Individual intolerance to the components of the drug;
- adrenal insufficiency;
- Acute and chronic renal and hepatic failure;
- Suspicion of an ectopic pregnancy;
- Long-term use of glucocorticosteroids;
- Myoma;
- The presence of scars in the uterine cavity;
- Violation of hemostasis;
- Anemia;
- Severe extragenital pathologies;
- CLD (including bronchial asthma);
- Heart failure;
- Heart rhythm disturbances;
- Severe forms of arterial hypertension;
- Pregnancy for more than 42 weeks;
- Pregnancy that occurred while taking hormonal contraceptives.
When preparing and conducting stimulation (induction) of childbirth:
- Severe degree of preeclampsia;
- Preeclampsia, eclampsia;
- Abnormal position of the fetus;
- Mismatch of the fetal head and the size of the mother's pelvis;
- Bloody discharge from the genital tract of unclear etiology;
- Premature or delayed pregnancy.
With leiomyoma: submucous location of myomatous nodes, the size of uterine leiomyoma, exceeding 12 weeks of pregnancy in size, ovarian tumors, endometrial hyperplasia.
With caution should be prescribed for chronic obstructive pulmonary disease, bronchial asthma, arterial hypertension, arrhythmias, chronic heart failure, heart rhythm disturbances.
Overdose
Reception in doses up to 2 g does not cause unwanted reactions. In cases of drug overdose, adrenal insufficiency may occur.
Mifepristone analogues, price in pharmacies
If necessary, you can replace Mifepristone with an analogue for the active substance - these are drugs:
- Ginepriston (from 260.00 rubles),
- (from 345.00 rubles),
- Ginestril (from 5470.00 rubles),
- Agesta.
ATX code matches:
- Agesta,
- Ginestril,
- Jenale,
- miropriston,
- Pencrofton.
When choosing analogues, it is important to understand that the instructions for use of Mifepristone, price and reviews, do not apply to drugs of similar action. It is important to consult a doctor and not to make an independent replacement of the drug.
Price in Russian pharmacies: Mifepristone 200 mg 1 tab. - from 650 rubles, according to 783 pharmacies. At the moment, there is practically no sale, the most affordable substitute is Ginepriston.
Store in a dry, dark place, out of the reach of children. Shelf life - 2 years.
Conditions for dispensing from pharmacies - by prescription.
Sometimes circumstances or medical indications force a woman to take such a step as terminating a pregnancy.
Active ingredient: mifepristone
Many today opt for medical abortion. Especially often for this purpose, a drug such as "Mifepristone" is used.
Benefits of Medical Abortion
Any surgical intervention is associated with certain risks. During a surgical abortion, there is a risk of mechanical injury, and the risk of infection increases due to the expansion of the cervical canal.
During vacuum regulation, which is considered one of the safest ways to terminate a pregnancy, there is a risk of incomplete release of the ovum, and menstrual irregularities are more serious.
Medical abortion is a more gentle procedure not only for the woman's body, but also for her psyche. After all, its implementation does not require a mechanical effect on the reproductive organs, even a short stay in a hospital or a sick leave. As statistics show, women around the world are increasingly choosing to terminate their pregnancy with the help of drugs.
Mifepristone is the drug of choice around the world
This medicine was created in France in the late 70s of the last century. And already in the 80s, he received a license and began to be used by doctors from different clinics in the world in combination with drugs for abortion in the early stages.
Today, Mifepristone tablets are widely used not only for early medical abortions. They are effective for terminating a pregnancy in the second trimester. Quite often, "Mifepristone" is used for missed pregnancy and to stimulate childbirth.
It is allowed to take "Mifepristone" in late pregnancy (from 13 to 22 weeks). It is also used for artificial childbirth after 22 weeks. The drug is recommended by WHO as a safe method of medical abortion.
In addition, the use of Mifepristone tablets during the conservative treatment of small uterine fibroids is quite effective.
I would like to note the huge popularity of the drug in Russia. For example, recently it has taken a leading position among medicines in the results of the search for OKPD.
mifepristone and misoprostol
The combination of "Mifepristone" with other drugs
Mifepristone is an antiprogestogen that blocks the action of progesterone, the pregnancy hormone. Under its action, the uterine mucosa loses its ability to hold the embryo, the cervix softens, and the uterus itself becomes more sensitive to prostaglandins - substances that cause it to contract. Therefore, the drug is most often used together with Misoprostol (prostaglandin).
The combination of these medicines helps to achieve a guaranteed result. As statistics show, in the first months of pregnancy, in 95% of cases, drugs are used successfully.
Some women experience expulsion of the ovum even before the use of misoprostol. For most, within a day after taking it. In a small proportion of patients, the process is delayed up to two weeks.
Many are interested in how much Mifepristone costs and where you can buy it. The price in the pharmacy for Mifepristone and Misoprostol is quite affordable, they are sold without a prescription and are freely available in many pharmacies. For example, in Russia, the average cost of Mifepristone in pharmacies is 3,000 rubles.
There are cheaper analogues, such as Mifolian (Chinese manufacturer), Pencrofton (Russian), Mirolut and Ginestril (Nizhpharm, Russia), Mifeprex (Russia). On the domestic market there is an analogue of "Mifegin", the international non-proprietary name (INN) of which is "Mifepristone".
Although the drug contains the same active ingredient, reviews about it are very contradictory. Therefore, before replacing one drug with another, analyze the opinions of those who have already experienced their effect.
In pharmacies, you can find a drug with the name "Mifepristone" from a Chinese manufacturer. It contains two active ingredients: mifepristone and misoprostol. According to reviews, the effect of the drug is quite aggressive, and often after its use there are consequences such as bleeding and inflammation. Therefore, when buying an abortive agent, carefully read the annotation, where its composition is indicated.
How is a medical abortion performed?
Often women are interested in how to take abortion drugs. Although detailed instructions for use and ease of use encourage a woman to drink Mifepristone at home, it is still best to always perform medical abortion under the supervision of a doctor.
Women who go for self-abortion do not know what the body's reaction to the drug will be.
To begin with, the doctor will prescribe the necessary examinations. It is important to exclude ectopic pregnancy, some internal pathologies. Since it is undesirable to delay the deadlines, in many clinics such examinations can be completed within one day.
If there are no contraindications, a woman can drink the first dose of Mifepristone directly in the clinic (no preparation for medical abortion is needed). After that, it is recommended to be under the supervision of a doctor for about 2 hours, so that he can make sure that there are no side effects of the drug. Then you can go home.
The next visit to the doctor usually occurs 2 days after taking the drug. During this period, bleeding may appear. The answer to the question, after how much Mifepristone begins to act, is strictly individual. For some, the abortive properties of the drug appear quite quickly, after a couple of hours, while others, when they visit the doctor again, say that nothing happens, the drug did not work.
If there is no discharge after Mifepristone, prostaglandins should be used. This happens about 40% of the time. After taking them, a miscarriage usually occurs in 95% of women. At this time, it is important that the gynecologist monitor the patient's condition. In some patients, everything proceeds in the same way as normal menstruation, only with the presence of clots. Someone has more bleeding, and the doctor can take timely measures if necessary.
There may be side effects such as severe vomiting, dizziness. Then it is necessary to adjust the dosage of the drug. Then, after 10-14 days, the doctor prescribes a control ultrasound to see if the fetal egg is completely expelled or if surgery is necessary.
In the later stages, the principle of using medical abortion is the same, but it must be carried out exclusively in a hospital setting. In most cases, everything passes without negative consequences.
mifepristone and alcohol
The combination of "Mifepristone" and alcohol
During the period of use of Mifepristone tablets, alcohol intake and smoking are strictly contraindicated. Alcohol can affect the processes occurring in the body in the most unexpected way.
Its interaction with an abortive drug can lead to unpredictable complications. And the ability to dilate blood vessels - to bleeding.
After the procedure, it is advisable to refrain from strong drinks and nicotine for another two weeks. Although a medical abortion has a gentle effect on a woman's body, hormonal changes occur after it, and ethyl alcohol can adversely affect its course.
Mifepristone to induce labor
Tablets "Mifepristone" at the 40th week of pregnancy are prescribed to stimulate delivery. This happens if the pregnancy is full-term. In this case, Mifepristone is used to soften the cervix and naturally expel the fetus. Sometimes Ginipral is used for this, and then an antiprogestogen.
Mifepristone is also prescribed at 41 weeks, when the woman is overweight and the cervix is immature. In this case, the stimulation of labor is much safer for the health of the mother and child than waiting for the natural onset of labor.