Mefenamic acid has anti-inflammatory and antipyretic properties. It helps to reduce the inflammatory process. This drug improves wound healing. The antipyretic effect of the drug is due to the fact that Mefenamic acid reduces the production of prostaglandins. The tool has an antiviral effect, since it improves the formation of interferon.
In what cases should it be applied?
Mefenamic acid is used in inflammatory diseases of the joints. The drug reduces swelling and relieves inflammation. It can be used for rheumatism and arthritis. The duration of the course of treatment for pathologies of the joints can reach two months. Mefenamic acid is effective in the complex treatment of influenza and viral infections.
The medication will help with women's problems: it should be used for dysfunctional dysmenorrhea and prolonged uterine bleeding. The drug can be taken with headache, muscle, postoperative pain.
What dosages are provided?
Mefenamic acid should be taken orally, after meals. The drug should be taken with milk. Children who have reached the age of 12 should drink 250 - 500 mg of the drug three times a day. The maximum daily dosage is 3000 mg. Upon reaching positive dynamics, the dose is reduced to 1000 mg. Children aged five to twelve years should take mefanamic acid no more than four times a day, 250 mg each. The duration of treatment is about a month. In the therapeutic treatment of a pain symptom, the drug must be consumed for at least a week.
What can be said about side effects?
Mefenamic acid causes adverse changes in the digestive system of the body. Often, when using the drug, abdominal pain, diarrhea and nausea occur. The drug can cause internal bleeding, stomach ulcers, pancreatitis. It often increases the level of liver enzymes in the blood. Acid also affects the hematopoietic system of the body: it can lead to anemia and thrombocytopenia. This medication can increase blood pressure, changes in heart rate. In rare cases, after taking the medicine, heart failure develops, edema appears.
The acid can cause bronchial spasms and an allergic reaction. It worsens the condition of the kidneys and nervous system. When taking the medicine, the patient is often disturbed by sleep, he becomes irritable. The drug negatively affects the senses: when taking this medication, there may be tinnitus, vision problems, inflammation of the eyes.
To whom is this medicine contraindicated?
In some cases, this medication should not be used:
- Mefenamic acid should not be taken with individual susceptibility to the components of the drug.
- This medicine is prohibited for use in gastric ulcer and inflammatory processes in the intestines.
- It should not be prescribed for severe blood diseases, serious pathologies of the liver and kidneys.
- Children under the age of five should not drink this medicine.
- The drug is forbidden to use during the period of bearing a child, during breastfeeding. The medicine increases the heart rate of the unborn baby.
- The drug should not be taken by women who plan to become pregnant in the near future, since after its use there may be problems with conception.
Be careful!
This drug has a large number of side effects. When treating with this drug, care must be taken:
- This medication should not be used by people who have had heart surgery.
- The use of this medicine is not recommended if you are allergic to aspirin.
- In elderly patients, adverse complications may occur during treatment.
- The risk group also includes patients with diabetes, epilepsy, angina pectoris. Such patients need to reduce the recommended dosage of the drug.
- If a person has systemic lupus erythematosus, taking the drug is not recommended due to the high likelihood of meningitis.
- Treatment should be discontinued if skin rash and diarrhea occur. With prolonged use of the drug, it is necessary to monitor blood parameters and kidney function.
- This medication dulls the natural reaction of the body, when treating with this drug, care must be taken when driving a machine.
Opinion of Dr. Komarovsky
A well-known pediatrician does not advise the use of mefenamic acid in the treatment of children. The pediatrician believes that this medicine is highly effective and quickly reduces the temperature. But the composition of the drug contains a large amount of harmful substances, so many developed countries have abandoned the use of this drug as an antipyretic.
Komarovsky writes that to reduce the temperature, it is better to use Paracetamol and Ibuprofen. These drugs meet all the necessary requirements. They are effective and suitable for the treatment of small patients.
How to use the healing paste correctly?
Paste and medicinal solution containing mefenamic acid must be used within a few days, so they should be prepared before use. The paste is used to get rid of toothache. The therapeutic course involves at least seven sessions. For ulcers on the mucous membrane of the oral cavity, applications are made using an aqueous solution of the agent. Such procedures should be carried out up to two times a day.
Useful remedy based on mefenamic acid
The Mefenat ointment, in addition to this acid, contains vilinin. It has a bacteriostatic effect. Vilinin is effective for wound healing. It can be used for trophic ulcers, purulent wounds, burns. This remedy is also prescribed for eczema, boils, severe cracks on the lips.
Polyethylene oxide is also present in the structure of the ointment. It reduces the inflammatory process and promotes deep penetration of the ointment into the skin.
The ointment has a local effect, it gives a long-lasting effect. The average duration of action is 10 hours.
The agent should be applied to the affected part of the body with a gauze swab twice a day. The drug has a slight analgesic effect. The duration of treatment is about 14 days. Sometimes there is irritation in the place where the ointment was applied. The redness usually goes away after a few days.
How does the drug interact with other drugs?
If you use this drug in parallel with taking Analgin, the inflammatory process in the patient will pass much faster. Other non-steroidal anti-inflammatory drugs are not recommended. Some doctors believe that in the treatment of acute respiratory diseases, in addition to Mefenamic acid, Immustat should be used. As the results of studies have shown, these two drugs interact perfectly with each other: they quickly eliminate the unpleasant manifestations of the disease, reduce the likelihood of complications.
Mefenamic acid is a fairly serious medicine, so you should consult your doctor before starting a course of treatment. In no case should you exceed the recommended dosage of the drug!
What is mefenamic acid? To date, the drug is very popular in arthrology, in the treatment of diseases of an infectious and inflammatory nature.
Pharmacological properties of the drug, as well as indications and contraindications for use, analogues and cost in this article.
mefenamic acid. General information
It is an anti-inflammatory, analgesic, antiviral drug.
The drug is widely used in arthrology, for the treatment of diseases of an infectious and inflammatory nature.
Pharmacological properties
Mefenamic acid is a derivative of anthranilic acid, belonging to the group of non-steroidal anti-inflammatory and antirheumatic drugs.
It affects the central and peripheral mechanisms of pain, reduces the local inflammatory process.
Helps to lower the temperature, due to the influence on the center of thermoregulation. The anti-inflammatory effect is obtained by stimulating the production of interferons. The effect of taking the drug occurs after three hours. Mefenamic acid is excreted from the body in the urine.
Composition and form of release
Mefenamic acid is a bitter gray-white powder, odorless.
Produced in the form of a tablet of 10 pieces in one cell, one or two packs in a cardboard box.
Active ingredient: mefenamic acid.
Excipients: talc lactose monohydrate, corn starch sodium lauryl sulfate; silicon dioxide; magnesium stearate.
Indications
Contraindications
Mefenamic acid should not be used if:
Carefully:
- - patients with epilepsy;
- - hypertension;
- - nonspecific ulcerative colitis;
Side effects
- - Has an undesirable effect on the central nervous system: drowsiness, weakness, irritation, convulsions, headaches;
- - nausea, vomiting, gas formation;
- - colitis, heartburn, hepatitis, jaundice, enterocolitis, pancreatitis;
- - high or low blood pressure;
- - arrhythmia;
- - gastritis;
- - bronchospasm;
- - cystitis;
- - renal failure.
The use of mefenamic acid
Way
Mefenamic acid is indicated to be taken orally, during a meal. The tablet or capsule is not divided and must be swallowed whole.
Dosage: adults 250 mg or 500 mg 3-4 times a day. The maximum daily dose is 3 grams.
The duration of the course of treatment is prescribed by the attending physician.
The daily dose of mefenamic acid for children aged five to twelve years should not exceed 1 gram. The exact dosage and duration of the course is determined by the attending physician.
Overdose
The drug has a rapidly rapidly absorbed into the gastrointestinal tract, so in case of an overdose, there may be: ulcers, erosion of the gastrointestinal tract.
Accompanied by the following symptoms: vomiting, nausea, increased or decreased blood pressure, shortness of breath, coma.
In case of an overdose of the drug, it is necessary: induce vomiting, take sorbents.
special instructions
Mefenamic acid should not be taken by patients with allergies to the components of the drug and non-steroidal anti-inflammatory drugs, heart failure, after undergoing heart surgery and with cirrhosis of the liver.
With caution: the elderly, patients with diabetes mellitus, circulatory disorders, bronchial asthma, stroke. This group of patients is prescribed a drug with a minimum dosage.
To reduce side effects on the gastrointestinal tract, mefenamic acid should be used during or after meals. If skin rashes and nausea occur, the drug should be discontinued.
Analogues
Preparations identical in composition and indications for use
Other analogues of the drug
Storage conditions
Store at temperatures up to 25 degrees, out of the reach of children.
Conditions for dispensing from pharmacies.
Released without a doctor's prescription.
Price
The cost of the drug depends on the form and packaging.
Average price: 240-300 rubles.
Name:
Mefenamic acid (Acidum mefenamicum)
Pharmachologic effect:
Mefenamic acid belongs to the group of NSAIDs and is a derivative of anthranilic acid, has analgesic, anti-inflammatory and antipyretic properties. It inhibits the synthesis of prostaglandins and serotonin, providing an anti-inflammatory effect. It affects both the central mechanisms of pain sensitivity and peripheral ones, causing a decrease in local inflammation in the focus. Stabilizes protein structures and cell membranes, reducing the permeability of the vascular wall. Reduces cell proliferation in the inflammatory focus, which stimulates healing.
The antipyretic effect is due to the influence on the thermoregulatory center and a decrease in the production of prostaglandins.
Antiviral effect - stimulates the formation of interferon, increases the ratio of T-helpers, increases the activity of T-lymphocytes.
When taken orally, the drug is rapidly absorbed in the gastrointestinal tract. Smax is observed after 2-4 hours, an increase in blood concentration is directly proportional to the dose taken. There is a high connection with blood proteins (albumin) up to 90%. Metabolized in the liver. Period T ½ 120-240 minutes. Eliminated in urine and partly in feces.
Indications for use:
Symptomatic therapy of pain syndrome,
Inflammatory processes of the osteoarticular apparatus: rheumatoid arthritis, rheumatism, ankylosing spondylitis,
Post-traumatic and post-operative manifestations such as pain, swelling and inflammation,
Blood loss in menorrhagia due to ovulatory dysfunctional bleeding in the absence of pathology of the pelvic organs,
functional dysmenorrhea,
In febrile conditions, as an antipyretic,
In the complex therapy of influenza and SARS.
Application method:
Pediatric age group 5 to 12 years: 250 mg three to four times daily. The duration of therapy is from 20 to 60 days or more.
With symptomatic therapy of pain syndrome, a short course of treatment is up to 7 days.
Undesirable phenomena:
The most common side effects are changes in the gastrointestinal tract, which are accompanied by dyspepsia, gastrointestinal discomfort, pain in the epigastric region, diarrhea, increased levels of liver enzymes, and can also provoke stomach ulcers and gastrointestinal bleeding.
Negative hematological effects were noted: hemolytic anemia, agranulocytosis, eosinophioia, thrombocytopenia or thrombocytopenic purpura.
Changes in the cardiovascular system: rhythm disturbances, increased blood pressure, peripheral edema, rarely congestive heart failure.
Changes in the respiratory system are accompanied by symptoms of bronchospasm and dyspnea.
Changes in the urinary system: dysuric manifestations, non-specific inflammation of the kidneys, impaired renal function, albuminuria, hematuria.
CNS changes: very rarely sleep disturbance and irritability.
Allergic reactions are manifested by urticaria and skin rashes.
Contraindications:
Individual intolerance to the drug,
peptic ulcer of the stomach and duodenum,
Inflammatory processes of the gastrointestinal tract,
Liver and kidney dysfunctions,
blood diseases,
Pregnancy,
lactation period,
Children's age group up to 5 years.
During pregnancy:
The period of pregnancy, lactation is a contraindication for the use of mefenamic acid.
Interaction with other drugs:
Mefenamic acid affects platelet function, which may enhance the effect of anticoagulant therapy and vitamin K antagonists.
Dicoumarin, opioid analgesics, vitamin B6, B1, phenothiazine derivatives may enhance the effect of mefenamic acid.
Methotrexate has more pronounced negative effects when taken simultaneously with mefenamic acid.
NSAIDs, warfarin in combination with the use of mefenamic acid increase the risk of developing gastrointestinal disorders.
Antacids increase the bioavailability of mefenamic acid, which increases its side effects.
Overdose:
Mefenamic acid in overdose has a pronounced tendency to provoke acute erosions or ulcers of the gastrointestinal mucosa, in rare cases, tonic-clonic convulsions. Treatment: symptomatic therapy, sorbents, gastric lavage, forced diuresis, urine alkalinization. There is no specific antidote. Hemodialysis is not effective due to the strong bond of the drug with albumin.
Release form of the drug:
Tablets p / o 500 mg in contour cells No. 10.
Packing cardboard No. 10, No. 20.
Storage conditions:
Stored at temperatures not exceeding 25 °C.
Compound:
The active substance is mefenamic acid.
1 tablet contains acidum mefenamicum - 500 mg
Excipients: potato starch, methylcellulose, croscarmellose Na, octadecanoic acid, magnesium stearate.
Additionally:
Mefenamic acid should not be used in patients who are allergic to aspirin or NSAIDs, have had heart surgery, have severe heart failure, ulcers, intestinal perforations, or severe cirrhosis.
Patients who may experience complications during treatment: the elderly, manifestations of dehydration, epilepsy, allergies, asthma, risk of stroke, angina pectoris, circulatory disorders, diabetes mellitus, bleeding disorders, porphyria, or decreased liver or kidney function. These situations may require a dose reduction or treatment change.
To reduce irritation of the gastric mucosa, the dose of the drug may be reduced, and it is also recommended to take mefenamic acid with food.
Therapy with the drug should be discontinued if symptoms of diarrhea or skin rash occur.
With prolonged therapy, it is necessary to monitor blood counts and liver and kidney function.
Mefenamic acid reduces the rate of reactions and is not recommended during therapy driving vehicles. Not applicable to children under 5 years of age.
Similar drugs:
Diclo-F (Diclo-F) Remisid (Remisid) Rapten gel (Rapten gel) Rapten (Rapten) Dolgit (Dolgit)
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Thanks a lot!Attention! The information is provided for informational purposes only. This manual should not be used as a guide to self-medication. The need for appointment, methods and doses of the drug are determined solely by the attending physician.
general characteristics
international and chemical names: mefenamic acid, N-(2,3-dimethylphenyl) anthranilic acid;
main physical and chemical properties: tablets of a flat-cylindrical form, grayish-white color with a slightly yellowish or greenish tinge (marbling is allowed), odorless;
compound: 1 tablet contains mefenamic acid - 0.5 g;
Excipients: potato starch, methylcellulose, talc.
Release form. Tablets.
Pharmacotherapeutic group
Nonsteroidal anti-inflammatory and antirheumatic drugs. ATC code М01А G01.
Pharmacological properties
Pharmacodynamics. Mefenamic acid-Darnitsa has anti-inflammatory, antipyretic and analgesic properties.
Affects phases (Phase- homogeneous, physically independent and separable part of a complex system) exudation and proliferation (Proliferation(from lat. proles - offspring, offspring and fero - I carry) - the growth of body tissue by neoplasm (reproduction) of cells. May be physiological (eg normal regeneration, breast cell proliferation during pregnancy and lactation) and pathological (eg tumors)) with inflammation. The mechanism of anti-inflammatory action is due to the ability to inhibit the synthesis mediators (Mediator- a substance that carries out the transfer of excitation from the nerve ending to the working organ and from one nerve cell to another) inflammation (prostaglandins, serotonin (Serotonin is a derivative of the amino acid tryptophan. It is synthesized mainly in the central nervous system and chromaffin cells of the gastrointestinal tract. The mediator of nerve impulse transmission through the synapse. Vertebrate brain neurons that use serotonin as a mediator are involved in the regulation of many forms of behavior, sleep processes, thermoregulation, etc. As a hormone, serotonin also regulates the motility of the gastrointestinal tract, mucus secretion, causes spasm of damaged vessels, etc. ), kinins (kinins- substances with a wide spectrum of biological activity. Kinins relax vascular smooth muscles, lower blood pressure, increase capillary permeability, cause pain, contract or relax the smooth muscles of isolated organs) etc.), reduce the activity of lysosomal enzymes (Enzymes- specific proteins that can significantly accelerate chemical reactions occurring in the body, without being part of the final reaction products, i.e. are biological catalysts. Each type of enzyme catalyzes the transformation of certain substances (substrates), sometimes only a single substance in a single direction. Therefore, numerous biochemical reactions in cells are carried out by a huge number of different enzymes. Enzyme preparations are widely used in medicine) that are involved in the inflammatory response. Mefenamic acid-Darnitsa stabilizes protein ultrastructures and cell membranes, reduces vascular permeability, uncouples oxidative phosphorylation, inhibits the synthesis of mucopolysaccharides, inhibits cell proliferation in the focus of inflammation, increases resistance (resistance- resistance of the body, immunity to any factors of external influence. In particular, nonspecific resistance refers to the means of innate immunity. The term is more often used in relation to microorganisms (the emergence of mechanisms of resistance to antimicrobial drugs, antibiotics) or plants (to diseases). In relation to humans and animals, the term immunity is more commonly used) cells and stimulates wound healing.
Antipyretic properties are associated with the ability to inhibit the synthesis of prostaglandins and influence the center of thermoregulation. In the mechanism of analgesic action, along with the influence on the central mechanisms of pain sensitivity, a significant role is played by the local effect on the focus of inflammation and the ability to inhibit the formation of algogens (kinins, histamine (Histamine is a derivative of the amino acid histidine. It is contained in an inactive, bound form in various organs and tissues, and is released in significant quantities during allergic reactions, shock, and burns. Causes expansion of blood vessels, contraction of smooth muscles, increased secretion of hydrochloric acid in the stomach, etc.), serotonin).
Unlike most other non-steroidal anti-inflammatory drugs, Mefenamic acid-Darnitsa stimulates the formation of interferon.
Pharmacokinetics. After ingestion, mefenamic acid is rapidly and fairly completely absorbed in the digestive tract. The maximum concentration in the blood is observed 2-4 hours after ingestion. The blood level is proportional to the dose. The equilibrium concentration (20 mcg / ml) is determined on the 2nd day of use (1 g 4 times a day).
Contacts albumin (Albumins- simple globular proteins contained in the blood serum are determined in the laboratory during a biochemical blood test) blood. In the liver, it forms metabolites by oxidation, hydrolysis, and glucuronidation. Half-life (Half-life(T1 / 2, a synonym for the half-life) - the period of time during which the concentration of drugs in the blood plasma decreases by 50% of the initial level. Information about this pharmacokinetic indicator is necessary to prevent the creation of a toxic or, conversely, ineffective level (concentration) of drugs in the blood when determining the intervals between injections) from the blood is about 3 hours. It is excreted from the body unchanged and as metabolites mainly by the kidneys (67% of the dose), with faeces (20-25%).
Indications for use
Mefenamic acid-Darnitsa is prescribed for the treatment of acute rheumatism, rheumatoid arthritis, ankylosing spondylitis (Bechterew's disease- a chronic inflammatory disease of the articulations and joints of the spine, especially the sacroiliac, intervertebral joints, costovertebral joints and joints of the processes of the vertebrae, tending to ankylosing (immobility of the joints)). Used for headache, toothache, arthralgia, myalgia (Myalgia- muscle pain due to spasm, compression, inflammation or ischemia of the muscles), fever (Fever- a special reaction of the body that accompanies many diseases and is manifested by an increase in body temperature. A febrile reaction most often occurs with infectious diseases, with the introduction of therapeutic sera and vaccines, with traumatic injuries, crushing of tissues, etc.), infectious-allergic myocarditis (Myocarditis- an inflammatory disease of the heart muscle of an infectious, allergic or toxic-allergic nature), dysmenorrhea (Dysmenorrhea- a cyclic pathological process in which severe pains in the lower abdomen appear on the days of menstruation. These pains may be accompanied by other symptoms: general weakness, nausea, vomiting, headache, dizziness, lack of appetite, dry mouth, salivation, bloating, etc.), premenstrual syndrome (Premenstrual syndrome(premenstrual tension syndrome) - a cyclic change in the mood and physical condition of a woman, occurring 2-3 days or more before menstruation, disrupting the usual way of life or work and alternating with a period of remission associated with the onset of menstruation, lasting at least 7-12 days), acute respiratory (Respiratory- respiratory, pertaining to respiration viral infections and influenza.
Dosage and administration
Mefenamic acid-Darnitsa is taken orally after meals (it is recommended to drink milk).
Adults and children over 14 years of age are prescribed 0.25-0.5 g 3-4 times a day.
If necessary, the daily dose can be increased to 3 g per day.
After achieving a therapeutic effect, the daily dose is reduced to 1 g.
Children aged 5 to 14 years are prescribed 0.25 g 3-4 times a day.
The duration of the course of treatment is 20-45 days (if necessary - 2 months or more).
Side effect
Nausea, heartburn, diarrhea (Diarrhea- rapid excretion of liquid stools associated with the accelerated passage of intestinal contents due to increased peristalsis, impaired absorption of water in the large intestine and the release of a significant amount of inflammatory secretion by the intestinal wall), abdominal pain, anorexia, flatulence (Flatulence- accumulation of gases in the digestive tract with bloating, rumbling, belching, cramping pains), gastrointestinal bleeding, constipation, general weakness, drowsiness, irritability, insomnia, visual disturbances, albuminuria, allergic reactions ( itching (Itching- a modified feeling of pain due to irritation of the nerve endings of pain receptors), edema (Edema- swelling of tissues as a result of a pathological increase in the volume of interstitial fluid) face, rash, etc.). With prolonged use (2 months or more) may develop hemolytic anemia (Hemolytic anemia- anemia due to increased hemolysis (destruction of red blood cells), which occurs due to a defect in the structure of red blood cell membranes), decrease in hematocrit, hematopoietic disorders. At a concentration of the drug in the blood of 100-200 mcg / l and above, muscle twitching, convulsions, and vomiting may be observed.
Contraindications
Peptic ulcer of the stomach and duodenum, inflammatory diseases of the digestive tract, diseases of the kidneys and blood-forming organs.
Overdose
In case of an overdose, muscle twitching, convulsions, vomiting, and respiratory disorders may occur.
Application features
Mefenamic acid-Darnitsa can cause a negative effect on the cardiovascular system of the fetus, so its use in pregnant women is not recommended.
The drug is able to penetrate into breast milk, so its use during lactation (Lactation- secretion of milk by the mammary gland should be limited.
Caution requires the use of the drug in persons with impaired renal function, in patients with bronchial asthma, as well as in persons with a history of gastric and duodenal ulcers.
Interaction with other drugs
With simultaneous use with analgin, the anti-inflammatory effect of Mefenamic acid-Darnitsa increases. Simultaneous use with other non-steroidal anti-inflammatory drugs increases the likelihood of side effects from the gastrointestinal tract.
Thiamine, pyridoxine hydrochloride, barbiturates, phenothiazine derivatives, narcotic analgesics (Analgesics- drugs that relieve or eliminate pain. Opium preparations, its alkaloids, their synthetic substitutes are called narcotic analgesics; analgin, paracetamol, acetylsalicylic acid, etc. - non-narcotic analgesics), caffeine, diphenhydramine increase the analgesic effect of the drug. Mefenamic acid-Darnitsa increases activity oral (oral- the route of administration of the drug through the mouth (per os)) anticoagulants.
Product General Information
Terms and conditions of storage. Store in a dry, dark place and out of the reach of children. Shelf life - 5 years.
Holiday conditions. Without recipe.
Package. 10 tablets in a blister pack.
Manufacturer.CJSC "Pharmaceutical firm "Darnitsa".
Location. 02093, Ukraine, Kyiv, st. Borispolskaya, 13.
Website. www.darnitsa.ua
This material is presented in free form on the basis of the official instructions for the medical use of the drug.
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One of the most unpleasant symptoms accompanying most diseases is pain. If the pain becomes unbearable, then there is both inflammation and swelling. Mefenamic acid can help with these unpleasant symptoms. This drug is used not only to eliminate the symptoms of the disease, but also in the treatment of ulcers and inflammation of the musculoskeletal system.
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Composition and properties
Mefenamic acid is available in the form of tablets, which include:
The active substance is mefenamic acid.
Mefenamic acid belongs to non-steroidal anti-inflammatory and antirheumatic drugs, and has the following properties:
Auxiliary substances - methylcellulose; starch; magnesium stearate; croscarmellose sodium; ocatedecanoic acid.
Indications and contraindications
Indications for the use of mefenamic acid are the following diseases or disorders:
In addition, the drug is used as an antipyretic for fevers. If a woman plans to become pregnant, you should refrain from using the drug, as it may interfere with fertility.
Contraindications to the use of mefenamic acid are:
- Pregnancy and lactation.
- Children's age up to five years.
- Blood diseases.
- Peptic ulcer of the stomach of the duodenum.
- Inflammatory processes of the gastrointestinal tract.
- Violations of the functions of the kidneys and liver.
- Gastritis.
- Cirrhosis of the liver.
- Heart failure.
- Allergic reaction to a component of the drug.
Mefenamic acid reduces the reaction rate, so it is not recommended to drive vehicles during the period of its administration. With caution, the drug is prescribed to patients with epilepsy or heart disease.
Instructions for use
The method of administration and dosage of Mefenamic acid depends on the age of the patient:
To reduce possible irritation of the gastric mucosa, the drug can be taken with meals.
Overdose, adverse reactions
In case of accidental overdose of the drug, the following symptoms may occur, in which you should immediately consult a doctor:
Treatment includes symptomatic therapy, forced diuresis, gastric lavage. Mefenamic acid binds strongly to blood proteins, so hemodialysis is not effective.
In addition to overdose, a possible rare manifestation of adverse reactions to the drug:
- Discomfort in the gastrointestinal tract.
- Pain in the intestines and stomach.
- Gastrointestinal bleeding.
- Rarely the development of ulcers.
- Purpura.
- Edema.
- Heart rhythm disturbances.
- An increase in blood pressure.
- Dysuric manifestations.
- Kidney dysfunction.
- Agranulocytosis.
- Eosinophilia.
- Hematuria.
- Irritability.
- Sleep disorders.
- Skin rash.
- Hives.
If any adverse reactions occur, do not make a decision on your own, it is important to immediately consult a doctor or call an emergency.
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