How long after hCG should be done after conception? When is blood donation for hCG indicated: before and after the delay. How to donate blood for hCG analysis

Instructions

HCG (human chorionic gonadotropin) is a special hormone secreted by the chorion (outer embryonic membrane) after the fertilized egg attaches to the wall of the uterus. Gonadotropin circulates in the mother's blood and is partially excreted unchanged in the urine. This is the basis for the determination of hCG in biological material. The longer the pregnancy, the higher the concentration of the hormone. In non-pregnant women, the content of gonadotropin in the blood ranges from 0 to 5 mU/ml, and is absent in the urine.

There are methods for determining hCG in urine at home and in blood in the laboratory. You can determine pregnancy at home using test strips, tablet and inkjet tests impregnated with a special reagent, which upon contact with gonadotropin causes the appearance of an additional second strip. The longer the pregnancy, the brighter the stripe will appear. The reliability of the results of these analyzes is 80-90%. Pregnancy is detected 12-14 days after conception. It is preferable to conduct the study in the morning, after taking hygiene procedures, following the steps specified in the instructions attached to a particular test.

The most accurate is a laboratory determination of the amount of hCG in the blood. The reliability of the results of this study ranges from 99-100%. Using special laboratory equipment, a quantitative assessment of the level of gonadotropin in the blood is made, giving specific numbers. This method allows 10-14 days after conception. To obtain correct results, it is necessary to prepare for the study. On the eve of donating blood, you should follow a diet that excludes fatty, fried foods, and alcoholic beverages. On the day of the procedure, it is not recommended to eat or drink drinks. It is acceptable to drink a glass of water. Blood is donated in the morning on an empty stomach in the treatment room of the antenatal clinic or any other medical institution.

You need to know that there are false positive and false negative results for determining the amount of hCG in biological material both at home and in the laboratory. Considering that the level of gonadotropin begins to increase after the egg attaches to the wall of the uterus, that is, on days 6-10 after conception, a test for the hormone should be carried out on days 2-3 of the delay. Otherwise, the test may result in a negative result if you are pregnant. Positive results for hCG in the absence of conception may be the result of a recent abortion or taking hormonal medications. If you suspect pregnancy, you should consult a gynecologist who will issue a referral to determine the level of hCG in the blood, and, if necessary, prescribe additional examinations to more accurately determine the duration of pregnancy.

  • threat of spontaneous abortion (reduced by more than 50%)
  • chronic placental insufficiency
  • true post-term pregnancy
  • fetal death (in the II-III trimester of pregnancy).

It happens that the test results show the absence of the hormone in the blood. This result may occur if the test was performed too early or during an ectopic pregnancy.

Whatever the result of the test for hormones during pregnancy, remember that only a qualified doctor can give the correct interpretation of hCG, determining which hCG is normal for you in combination with data obtained by other examination methods.

How to take a blood test for hCG correctly

Your doctor should tell you how to properly prepare for the test and when to take it. We will only give general recommendations if you have not received them from your gynecologist. To perform an analysis for hCG, blood is taken from a vein.

  • It is recommended to donate blood in the morning and strictly on an empty stomach.
  • If you take the hCG test at another time, you must fast from food for 4-6 hours.
  • And you should tell your nurse or your doctor if you are taking any hormonal medications.

It is recommended to carry out a laboratory test to determine pregnancy in the early stages no earlier than 3-5 days of missed menstruation. The pregnancy blood test can be repeated after 2-3 days to clarify the results. A blood test for beta-hCG in our medical center can also be performed urgently. In a comprehensive diagnosis of pregnancy in the early stages, along with an analysis for hCG, it is necessary to do an ultrasound with a vaginal sensor. To identify fetal pathology in pregnant women, a test for hCG, human chorionic gonadotropin, is taken from 14 to 18 weeks of pregnancy.

The hCG level during pregnancy is one of the most important indicators, which indicates, in particular, the normal development of pregnancy and helps to diagnose a variety of pregnancy disorders at an early stage. It is for this reason that every pregnant woman is recommended to take a blood test for hCG - this is a necessary measure for the timely detection of various problems at different stages of pregnancy. And the expectant mother must be informed by her gynecologist about exactly when it is necessary to donate blood for hCG.

  • You may have a miscarriage

How should hCG rise normally?

If the pregnancy develops successfully, the hCG level will constantly increase until 10-12 weeks, and then begin to fall. HCG dynamics (that is, how hCG levels change as pregnancy progresses) can be completely different for each pregnant woman, so there are no strict norms for the rise of hCG levels. However, in most cases, hCG levels double approximately every 1-3 days by week 4, and then approximately every 3.5 days by week 9. After 10-12 weeks of pregnancy, hCG begins to fall - this is normal.

If the hCG level does not increase or decreases, then you need to contact a gynecologist as soon as possible. Such dynamics may indicate a miscarriage or missed pregnancy.

If the hCG level is growing very quickly, you should also visit a gynecologist who will rule out possible complications, for example, hydatidiform mole.

HCG and the risk of Down syndrome in the unborn child

In order to determine the risk of having a child with Down syndrome, a series of examinations is performed, which are called screening of the first and second trimester of pregnancy. In the first trimester of pregnancy (from 11 weeks to 13 weeks and 6 days), among other tests, the level of hCG in the pregnant woman’s blood is measured. If hCG levels are elevated, the baby may be at increased risk of Down syndrome. On our website there is a separate article devoted to this topic: Screening in the first trimester of pregnancy: results, risk calculation.

What medications affect the level of hCG in the blood?

The level of hCG in the blood can only be affected by medications that themselves contain this hormone (Pregnil, Horagon). These drugs are used mainly in the treatment of infertility by stimulating ovulation. If you have taken one of these medications, or have taken a course of ovulation stimulation, be sure to tell the laboratory where you are taking the test.

No other medicine can distort (increase or decrease) the result of a blood test for hCG. Birth control pills do not affect hCG blood test results or pregnancy test results.

Can the hCG test result be wrong?

There is always a risk of erroneous hCG blood test results. These results are called false positives and false negatives.

False-positive results of a blood test for hCG (when a woman is not pregnant, but the test shows a positive result) is relatively rare (approximately 0.01-2% of cases). If you suspect that the result of your test is incorrect, contact your gynecologist and consult with him what to do next (usually, in this case, the gynecologist will prescribe a repeat test or additional examinations).

False-negative results of a blood test for hCG (when a woman is pregnant, but the test shows a negative result) can occur if the rules for donating blood for analysis were violated, if the gestational age was incorrectly determined, you had late ovulation or late implantation (attachment of the fetus in uterus). In very rare cases of ectopic pregnancy, hCG blood test results may also be false negative. If you suspect that the hCG blood test was incorrect, consult your gynecologist.

Blood test for hCG in menopause (menopause)

In women who have already entered menopause (after menstruation has stopped), the level of hCG in the blood may be slightly elevated. Thus, some gynecologists consider it normal if, after the onset of menopause, the level of hCG in a woman’s blood reaches 14 mIU/ml (mIU/ml) (while in women before the onset of menopause, the hCG level normally does not exceed 5 mIU/ml (mIU/ ml)).

Blood test for progesterone to determine pregnancy

In some cases, in addition to determining the level of hCG in the blood, the doctor also recommends a blood test for progesterone. Progesterone is a pregnancy hormone, and its level can determine how successfully your pregnancy is developing.

Most doctors believe that a progesterone level above 25 ng/ml (or 79.5 nmol/l) in early pregnancy means the pregnancy is progressing well. If the level of progesterone during pregnancy is less than 5 ng/ml (or 15.9 nmol/l), then the chances of a successful pregnancy are quite low. Intermediate values ​​from 5 to 25 ng/ml (or from 15.9 nmol/l to 79.5 nmol/l) require repeated measurements after some time.

How does the hCG level change after a miscarriage (miscarriage or abortion)?

In the first few days and even weeks, the level of hCG in the blood may remain elevated. However, if the pregnancy is terminated, the hCG level will gradually decrease (but in no case increase). In most cases, hCG levels return to normal within 4 to 6 weeks after a miscarriage or abortion.

When can you donate blood for hCG?

Guest | 08/07/2013, 14:46:59

the delay is three days, the test is negative... and the condition is normal, as if they are not going to come (Critical days) how long after unprotected PA can you donate blood for hCG? It's been a week since the last PA. Isn't it too early?

    Yes, you can just buy a test at the pharmacy - it will show.

    test negative

    HCG - 12 days after the expected date of arrival, and tests often lie.

    I found out that hCG will be told only after 4 days of testing, again wait that long(

  • 7. | 07.08.2013, 15:33:51
  • Come on! In St. Petersburg in Helix I took it in the morning and received the results in the evening. Or are you talking about the district clinic 😉?

    in Kazan so

  • Pin

    the tests don’t lie, you just need to do it on morning urine (actually, they write about this in the instructions). The tests “catch” a certain level of hCG, usually it starts at 20 for the most sensitive tests. There is no point in donating blood if you can wait two days and do a regular test because the hCG level doubles every 48 hours.

    just to be sure

  • 11. | 07.08.2013, 15:37:17
  • Pin

    9 What difference does it make to find out today or in 4 days? The longer the period, the more likely it is that the test will show it the first time. The test is kind of cheaper than a blood test. But no, no, your period will come.

    Well, he’s already negative three times. And still no months. I've never had any delays

  • 13. | 07.08.2013, 15:39:38

    The tests show perfectly from the first day of the delay; well, if ovulation was late, then after 5 days it will definitely show if you do it in the morning on what is called an empty stomach. Everything else is a fairy tale about 3 months of catching hCG.

  • Guest
  • 15. | 07.08.2013, 15:40:41
  • 16. | 07.08.2013, 15:43:03
  • Lark

    Well, if the test was done correctly (and to be on the safe side, preferably 2 times), then red days will probably come. In general, listen to your feelings - many, like me, for example, realized within a couple of days after conception that they were pregnant (this was the first pregnancy) - maybe your breasts became swollen, or your blood pressure dropped, irritability appeared, or you were craving something from food . Well, if you really want to donate blood for hCG, then you can already donate - it will show for sure. My sister took the test even before the delay - the pregnancy was confirmed. And you already have a delay, albeit a small one.

    I have irritability... maybe that’s why they haven’t come for another month. My breasts don’t seem to be swollen, my nipples hurt... I don’t feel like eating, I want to smoke, no matter how funny it sounds) I haven’t smoked for two years. So I’ll move out tomorrow and rent it out. maybe tomorrow they will come... thank you!

  • Pin

    Has it been a week since PA? It’s too early to do the test and the hCG analysis will not show you anything, because add 4-5 days here until your egg reaches the uterus and is implanted, and only then the production of hCG will begin, which you will catch only after a week on average.

  • 19. | 07.08.2013, 15:45:37
  • Maybe that’s why the tests don’t show anything..?

    I read the wrong message. I missed the test. It turns out it won’t show anything... how long to wait((so much patience is needed

  • Pin

    Author, here is a short excursion for you. On average, it is considered that if you have a stable regular cycle of approximately 28 days, then you ovulate on day 14, usually conception occurs in this range, well, until it gets there, until it attaches, an average of two weeks will pass when you start to have a delay. those. plus +14 days.

    yes, I know that... but in general it happened several days before the expected period, in fact there may not be a pregnancy, but this delay was confusing...

  • 04-04-145. Free beta subunit of human chorionic gonadotropin (free b-hCG) Cost of service (Kazan, Almetyevsk, Bugulma, Volzhsk, Zelenodolsk, Yoshkar-Ola, Naberezhnye Chelny, Novocheboksarsk, Arsk, Vysokaya Gora): 310.00 rub. Completion time (in the laboratory): from 1 working day. here are the addresses:
  • and even faster - generally 3-4 hours DIAGNOSTICS prenatal fetus and placenta. failure in the CITO (ICA) mode. Common beta subunit of hCG Completion time - 3-4 hours Address: LUKOVSKOGO, 8. Central OFFICE Telephone: 5-333-333, fax: 236-76-98

    HCG is given on the 25-26th day of the cycle, it will already show if there is anything

    I'm nowhere near day 25-26(

  • 27. | 07.08.2013, 20:41:08

    In about 2 weeks. While the embryo is fixed, it begins to produce. Tests usually have a sensitivity of 15-20 units. And the test will immediately show you the exact number. More than 5, a reason to think about it... The doctor recommended that I take it after 2-3 days of delay.

  • 31. | 08.08.2013, 06:12:22
  • Guest

    I put 2 drops in and again no...could this be implantation bleeding? or does it happen only before the delay?

    is it possible to be pregnant or not?

  • 34. | 04.11.2013, 20:07:08

    Girls, tell me. There was a three-day delay, I took two different tests, both positive. But the lower abdomen hurts, like during menstruation. Not intrusive. I do something and forget. Is this normal? I have a voucher to see the gynecologist only in two days. I decided to take a hCG test tomorrow.

  • 35. | 07.12.2013, 21:28:40

    I am writing for everyone who claims that the test is reliable from the first day of delay. My test showed two lines on the SEVENTEENTH day!!! And there was also a case where the test showed pregnancy, but it wasn’t there (I then took HCG), so tests are unreliable!!!

  • 40. | 13.01.2014, 12:44:20
  • I have the same question, day after day..... I want to do hCG tomorrow, is there any point?

  • 42. | 13.01.2014, 22:19:58

    Pa was the day after my period ended! When can I do a test or donate blood for hCG??? help guys, what is the probability of pregnancy?!

  • Alla

    I have a question: the expected day of conception was January 1st, today is January 13th, when can I take a test and donate blood for hCG? Thank you in advance!

    That turns out to be 12 depots, you can safely get tested

  • 44. | 29.01.2014, 15:04:26

    girls, is it better to do an hCG or a test last night I hardly slept I woke up from increased salivation at night I thought I would hug the potty, but no, I went to bed again, started simmering and after 2 hours it happened again half a day I have no strength, I have no strength, I feel sick, I have a nasty taste in my mouth (really) (I just I forgot how it happens, I have three beauties but we want more, but for four years there hasn’t been a single flight)

  • 46. | 02.02.2014, 18:27:08

    Girls, tell me, please. I'm already climbing the wall. I feel constantly sick, I constantly eat something, I eat a lot, I even overeat (which is very strange for me, because I eat little, with a height of 170, I weigh 49.5) over the last week I have gained a kilo, for me this is a lot (because it’s very difficult for me to get better) I’ve been stretching my lower abdomen (slightly) all last week, I’ve become very irritable, and my husband says that my mood is changing very much, although I don’t notice it and my nipples really hurt. Everyone unanimously repeats (even my husband) that it looks like I’m pregnant. Estimated date of conception is January 19. 14 days have passed, I took a test 2 days ago and it was negative. Your period should come in just a week, so there is no delay. Should I run for another test? What are your thoughts on this matter? Thank you in advance.

  • 48. | 18.02.2014, 23:10:08

    The unprotected PA was 09.02. (Well, it looks like he didn’t cum in me) ms were from 01.02 to 04.02. The cycle sometimes varies, but on average it is 26 days! Took a test, negative. The feeling is strange, maybe due to stress. It felt like ovulation was on 14.02. Could I be pregnant?

  • 49. | 21.02.2014, 06:45:44

    Gulya, the test should be done 2-3 days after a missed period. And on days 12-14 from the expected conception, you can donate blood for hCG. And on the 5th day after your period, the chances of getting pregnant are minimal.

  • 50. | 26.02.2014, 19:36:43

    hello, I had sexual intercourse on January 30th, and my period started on January 31st, is it possible to get pregnant? 26 days have passed since the supposed conception, I did an hCG test, the result is negative, there has been no delay yet. There are still 12 days before it, can I trust hCG in this situation? or do it again after a delay?

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It should be understood that these indicators are not absolute and accurate. The hCG level during pregnancy may deviate slightly from the norm, and this does not mean that there are any abnormalities or pathological changes in the fetus.

In most cases, doctors monitor the dynamics of hormone levels throughout the entire period of gestation.

How to prepare for research?

A blood test for the presence of hCG is carried out only in medical institutions. Only venous blood is needed. Beforehand, you should not eat or drink drinks 8-10 hours before. This is a prerequisite for passing any analysis. It is precisely because this condition is not met that many analyzes become incorrect. By the way, ordinary seeds or spicy adjika can provoke a positive result when donating blood for sexually transmitted diseases. In addition, when taking a test during pregnancy, you should not be sexually active and try not to overload your body with physical activity; these factors greatly influence the result and determination of pregnancy.

If before conducting the study, a person took medications for 2-3 months, this should be reported to the attending physician. For pregnant women, the test can be taken as early as the fourth week after conception, and to identify pathologies - two weeks after the first examination. If it is necessary to study diseases, blood is donated at intervals of 4-7 weeks, depending on what disease needs to be identified.

The study may also be erroneous when a person took medications that included human chorionic gonadotropin. These medications are taken mainly to stimulate ovulation. Treatment of infertility requires taking this hormone. No more medicine can affect the level and indicator of hCG in the blood. Many women ask whether taking contraceptives can affect the amount of the hormone in the blood. The answer is clear - no. Despite the fact that almost all birth control pills contain a small percentage of hormonal agents, other hormones will not be able to increase or decrease the level of human chorionic gonadotropin.

What does high and low hormone levels mean?

A low level of production of human chorionic gonadotropin can be interpreted as the presence of such abnormalities:

  • ectopic pregnancy (indicator will be below 0);
  • frozen fetus or its death;
  • physiological delay in embryo development;
  • risk of miscarriage;
  • pathological abnormalities in the structure of the placenta;
  • the presence of genomic pathology in the fetus.

Only an experienced doctor can decipher the hCG analysis during pregnancy. Again, do not forget that you should not eat food before donating blood. Only in this case can the level of the hormone in the blood be correctly deciphered.

In an ectopic pregnancy, the fertilized egg implants in the fallopian tubes or in the abdominal cavity. This means that the pregnancy cannot develop normally, and in some cases serious consequences and abnormalities occur. The interpretation and the result will show that the level of the hormone during an ectopic pregnancy is initially increased, but is not the same as during conception in the uterus, but 4 units less. But, by the fifth week, the amount of the hormone decreases sharply. One such study, of course, will not be able to determine an ectopic pregnancy; this requires the results of an ultrasound examination.

When the fetus dies, human chorionic gonadotropin levels drop sharply. In the early stages of pregnancy, the fetus undergoes a toxic process with fading.

When a woman is not planning a pregnancy and knows for sure that there was no fertilization process, but after taking tests for production, she receives a result that shows that the level of the hormone is increased, this can be an alarming sign.

Genomic pathology in the fetus scares many expectant mothers. Today, doctors conduct special examinations in order to identify the presence of this pathology as quickly as possible. For this purpose, screening is carried out in the 1st and 2nd trimester. The first trimester is decisive; if a woman has a high hormone level, then the fetus has obvious pathological abnormalities. But you don’t need to panic right away; you need to see a doctor who can interpret the hCG analysis. High levels of the hormone may mean that a pregnant woman has two or more fetuses. If toxicosis is too strong, its amount will also be increased.

In men, a high level of the hormone can mean diabetes or gestosis. In any case, it is impossible to determine from one study, because in some cases, when the hormone rises, it seems to warn that bleeding is possible. In order to correctly interpret and decipher the analysis, it is necessary to undergo several more types of examination and only then draw the appropriate conclusions.

Any tests are always repeated in order to eliminate the risk of error. HCG analysis during pregnancy is no exception. The result and decoding may also be erroneous. Erroneous analyzes fall into two categories:

  • false positive test result;
  • false - negative.

Although such results are rare, there is still a risk of erroneously detected hormone levels.

We can talk about false-positive results of blood tests for hCG if a woman is not fertilized, but the result showed the opposite. In this case, a repeat analysis is prescribed after 2.5 weeks. The reasons for such a blood test for hCG may be:

  • violation of the rules for donating or collecting blood;
  • incorrect deadline;
  • ovulation disorder in a woman;
  • untimely attachment of the embryo.

The level of the hormone in a woman’s blood can change after a premature termination of pregnancy and after a spontaneous miscarriage has occurred. 7 weeks after the pregnancy is terminated, naturally or forcibly, the hormonal level will return to normal. If it increases, it will be necessary to undergo additional examinations; repeated interpretation will help determine the reason for the increase in the level of the hormone in the body. In some cases, after an incorrectly performed operation, accumulations may remain in the uterine cavity; the level of the hormone will also be increased in this case and will decrease only when a repeat operation is performed.

In some women, human chorionic gonadotropin levels may be high when menopause begins (menopause). The decoding will show that the hormone level in a woman who has not reached menopause (under 50 years old) is 4, during menopause it rises to 15. In such cases, doctors prescribe medications to women that can regulate the hormone level.

HCG (human chorionic gonadotropin) or hCG (chorionic gonadotropin) is a special pregnancy hormone.

Pregnancy can also be diagnosed using home pregnancy tests based on the analysis of hCG excreted in the urine. But the reliability of the hCG result obtained “at home” is significantly lower than the laboratory hCG blood test, since the level of hCG required for diagnosis in the urine is achieved several days later than in the blood

The hCG hormone is produced by chorion cells (the membrane of the embryo). Based on a blood test for b-hCG, the doctor determines the presence of chorionic tissue in the body, which means the woman is pregnant. The hCG blood test makes it possible to detect pregnancy early - already on days 6-10 after fertilization, the hCG result will be positive.

The role of hCG in the first trimester of pregnancy is to stimulate the formation of hormones necessary for the development and maintenance of pregnancy, such as progesterone, estrogens (estradiol and free estriol). During the normal development of pregnancy, these hormones are subsequently produced by the placenta.

Human chorionic gonadotropin is very important. In a male fetus, hCG stimulates the so-called Leydig cells, which synthesize testosterone. Testosterone in this case is simply necessary, as it promotes the formation of male-type genital organs, and also has an effect on the adrenal cortex of the embryo.

We will present the most common cases when a doctor prescribes an hCG test.

Diagnosis of pregnancy in the early stages

Rule out the possibility of ectopic pregnancy

To assess the completeness of induced abortion

HCG is also given for dynamic monitoring of pregnancy

In case of threat of miscarriage and non-developing pregnancy

Diagnosis of tumors - chorionepithelioma, hydatidiform mole

Along with AFP and free estriol - as a prenatal diagnosis of fetal defects

Norms of hCG in blood serum

HCG norm, honey/ml Men and non-pregnant women< 5 Уровень ХГЧ при беременности: 1 — 2 неделя 25 — 300 2 — 3 неделя 1500 — 5000 3 — 4 неделя 10000 — 30000 4 — 5 неделя 20000 — 100000 5 — 6 неделя 50000 — 200000 6 — 7 неделя 50000 — 200000 7 — 8 неделя 20000 — 200000 8 — 9 неделя 20000 — 100000 9 — 10 неделя 20000 — 95000 11 — 12 неделя 20000 — 90000 13 — 14 неделя 15000 — 60000 15 — 25 неделя 10000 — 35000 26 — 37 неделя 10000 — 60000

Decoding hCG Normally, during pregnancy, hCG levels gradually increase. During the 1st trimester of pregnancy, b-hCG levels increase rapidly, doubling every 2-3 days.

At 10-12 weeks of pregnancy, the highest level of hCG in the blood is reached, then the hCG level begins to slowly decrease and remains constant during the second half of pregnancy.

An increase in beta-hCG during pregnancy can occur when:

multiple births (hCG rate increases in proportion to the number of fetuses)

fetal pathologies, Down syndrome, multiple malformations

incorrectly determined gestational age

An increase in hCG can be a sign of serious diseases in non-pregnant women and men:

  • Edwards syndrome.

How is hCG related to the risk of having a child with Down syndrome?

To determine the risk of this pathology, a prenatal diagnostic system is carried out, which includes determining the concentration of hCG and identifying specific signs on ultrasound.

If the concentration of the hormone in the blood is increased, there is a high risk of the embryo having Down syndrome.

How does the level of hCG in the blood change after a miscarriage or abortion (ectopic and frozen pregnancy)?

A few days after termination of pregnancy, a high concentration of the hormone in the serum is observed, then a gradual decrease in the level of hCG occurs. Most often, it returns to normal levels 4 to 6 weeks after a spontaneous or medical abortion.

During ectopic pregnancy, significantly less hCG is produced than during uterine implantation of the embryo. If the level of hCG increases slowly, then an ultrasound is performed to detect a fertilized egg in or outside the uterus.

If, with a positive test and the absence of menstruation, signs of pregnancy do not occur, or they quickly disappear, a non-developing (frozen) pregnancy can be assumed. The level of hCG in dynamics stops growing, and then sharply decreases.

Read also: Decoding the results of a general urine test in children and adults - all the norms in the tables

Could the results be wrong?

When testing blood for hCG, an erroneous result can occur if the rules for blood sampling, serum storage, or research methods are violated.

A negative result is observed with late implantation of the embryo. In doubtful cases, repeated examination, ultrasound diagnostics and other studies are carried out.

How does the use of medications affect the level of hCG in the blood?

The concentration of human chorionic gonadotropin in the blood can only be affected by medications that contain this hormone. They are most often prescribed to stimulate follicle rupture. If you have taken such drugs, tell your doctor.

No other hormonal drugs, including oral contraceptives, can distort the result of a serum hCG test.

Prices and terms, how long to wait for the result of a hCG test?

The duration of a laboratory blood test for the hormone is approximately 2-3 hours. You can get the test result on the same day if the blood was taken in the morning, or the next day.

In some cases - when laboratory staff are busy or to save reagents - the test is carried out once every few days, when a sufficient number of samples have accumulated.

The cost of a blood test for hCG in Moscow is on average 750 rubles.

Read also: Blood test for thyroid hormones

Feedback from women about taking the test

I used to think that why donate blood from a vein once again if pregnancy can be determined using a test purchased at a pharmacy. But it so happened that there was a delay, the test showed that there was no pregnancy. The doctor ordered a hCG test and an ultrasound. A blood test for the hormone gave the result that there is a pregnancy and is developing normally. What was confirmed by ultrasound. I’m afraid when they take blood from a vein. They are barely noticeable to me. But thanks to this analysis, I was promptly diagnosed with an ectopic pregnancy and had an abortion. Otherwise there could be dire consequences. I also know that with the help of this study, the risk of developing various defects in an unborn child at an early stage, for example, Down syndrome, is determined. Sometimes, using ultrasound, it is impossible to accurately determine the gestational age. This happened to me; my calculations did not coincide with the doctors’ calculations. Then, as an addition, it would be nice to do a blood test for hCG. Although, of course, you don’t want to prick a vein again. Is it useful? Share!Analysis of amniotic fluid and technique for its implementation

Amniocentesis is a medical procedure used in perinatal diagnosis, which consists of puncture of the amniotic sac followed by removal of amniotic fluid for laboratory testing for the purpose of early diagnosis of genetic and chromosomal abnormalities, determination of the sex of the fetus, as well as for amnioreduction in cases of polyhydramnios or the administration of medications to terminate pregnancy. .>

  • threat of spontaneous abortion (reduced by more than 50%)
  • chronic placental insufficiency
  • true post-term pregnancy
  • fetal death (in the II-III trimester of pregnancy).

It happens that the test results show the absence of the hormone in the blood. This result may occur if the test was performed too early or during an ectopic pregnancy.

Whatever the result of the test for hormones during pregnancy, remember that only a qualified doctor can give the correct interpretation of hCG, determining which hCG is normal for you in combination with data obtained by other examination methods.

How to take a blood test for hCG correctly

Your doctor should tell you how to properly prepare for the test and when to take it. We will only give general recommendations if you have not received them from your gynecologist. To perform an analysis for hCG, blood is taken from a vein.

  • It is recommended to donate blood in the morning and strictly on an empty stomach.
  • If you take the hCG test at another time, you must fast from food for 4-6 hours.
  • And you should tell your nurse or your doctor if you are taking any hormonal medications.

It is recommended to carry out a laboratory test to determine pregnancy in the early stages no earlier than 3-5 days of missed menstruation. The pregnancy blood test can be repeated after 2-3 days to clarify the results. A blood test for beta-hCG in our medical center can also be performed urgently. In a comprehensive diagnosis of pregnancy in the early stages, along with an analysis for hCG, it is necessary to do an ultrasound with a vaginal sensor. To identify fetal pathology in pregnant women, a test for hCG, human chorionic gonadotropin, is taken from 14 to 18 weeks of pregnancy.

The hCG level during pregnancy is one of the most important indicators, which indicates, in particular, the normal development of pregnancy and helps to diagnose a variety of pregnancy disorders at an early stage. It is for this reason that every pregnant woman is recommended to take a blood test for hCG - this is a necessary measure for the timely detection of various problems at different stages of pregnancy. And the expectant mother must be informed by her gynecologist about exactly when it is necessary to donate blood for hCG.

Currently, there are several methods that allow you to quickly and accurately determine the presence of pregnancy. One of the most popular of them are pregnancy tests sold in pharmacies. However, a more accurate result can be obtained by conducting a blood test for pregnancy, based on determining the level of the hCG hormone.

What is hCG

A special hormone that is not produced in the body of a man or a non-pregnant woman is human chorionic gonadotropin, abbreviated as hCG. When pregnancy occurs, the membranes of the fetus, namely the chorion, begin to secrete this hormonal substance. The presence of gonadotropin in the blood makes it possible to accurately determine pregnancy using a blood test.

It is for this reason that this test is called a pregnancy blood test.

Does a blood test indicate early pregnancy?

As follows from the instructions for the standard pharmacy test, based on the presence of chorionic hormone in the urine, a reliable result can be obtained no earlier than the first day of the delay. Pregnancy can be determined by a blood test already on the tenth day from the moment of fertilization, that is, approximately a week before the next planned menstruation. Thus, the possibility of earlier diagnosis when taking a blood test for pregnancy and the period at which this study can be carried out are the undoubted advantages of this method over a “regular” test from a pharmacy. However, such an analysis was created not only so that impatient parents would know the desired results as quickly as possible.

Blood test for pregnancy: normal hCG levels

Many women wonder what hCG levels should be at a given stage of pregnancy. It should be noted that each of these periods has fairly wide boundaries of normal values, which is why it is not always possible to find out how well the embryo is developing. However, if you take a pregnancy blood test twice or more, you can almost always get the correct results. In some situations, it is impossible for expectant mothers to undergo any other examinations other than being offered a blood test for pregnancy, so in such situations they have to rely only on the results obtained from a blood test for hCG.

The unit of measurement for human chorionic hormone levels is mU/ml. For men and women who are not currently expecting a child, the hCG value is less than 5. For pregnant women, the norm for this hormone is determined for each period of pregnancy separately.

Compared to the initial value of less than 5 mU/ml, the level of chorionic hormone in the blood of a woman carrying a child will always be elevated. And in some cases, the level of this hormone increases even more than it should be at the appropriate stage of pregnancy. A significant increase in the level of human chorionic gonadotropin occurs during the patient’s multiple pregnancy. In this case, the value of this hormone can exceed 1.5-2 times or even more the normal level of hCG for each stage of pregnancy.

A study such as a blood test for hCG does not need to be carried out in every case of pregnancy. If pregnancy proceeds safely, then there is no need to take this test. However, in any case, performing a blood test for hCG provides diagnostic information, on the basis of which it is possible to identify possible disorders in the development of the fetus, select the necessary treatment, and, if the child develops normally, please future parents with such information.

  • You may have a miscarriage

How should hCG rise normally?

If the pregnancy develops successfully, the hCG level will constantly increase until 10-12 weeks, and then begin to fall. HCG dynamics (that is, how hCG levels change as pregnancy progresses) can be completely different for each pregnant woman, so there are no strict norms for the rise of hCG levels. However, in most cases, hCG levels double approximately every 1-3 days by week 4, and then approximately every 3.5 days by week 9. After 10-12 weeks of pregnancy, hCG begins to fall - this is normal.

If the hCG level does not increase or decreases, then you need to contact a gynecologist as soon as possible. Such dynamics may indicate a miscarriage or missed pregnancy.

If the hCG level is growing very quickly, you should also visit a gynecologist who will rule out possible complications, for example, hydatidiform mole.

HCG and the risk of Down syndrome in the unborn child

In order to determine the risk of having a child with Down syndrome, a series of examinations is performed, which are called screening of the first and second trimester of pregnancy. In the first trimester of pregnancy (from 11 weeks to 13 weeks and 6 days), among other tests, the level of hCG in the pregnant woman’s blood is measured. If hCG levels are elevated, the baby may be at increased risk of Down syndrome. On our website there is a separate article devoted to this topic: Screening in the first trimester of pregnancy: results, risk calculation.

What medications affect the level of hCG in the blood?

The level of hCG in the blood can only be affected by medications that themselves contain this hormone (Pregnil, Horagon). These drugs are used mainly in the treatment of infertility by stimulating ovulation. If you have taken one of these medications, or have taken a course of ovulation stimulation, be sure to tell the laboratory where you are taking the test.

No other medicine can distort (increase or decrease) the result of a blood test for hCG. Birth control pills do not affect hCG blood test results or pregnancy test results.

Can the hCG test result be wrong?

There is always a risk of erroneous hCG blood test results. These results are called false positives and false negatives.

False-positive results of a blood test for hCG (when a woman is not pregnant, but the test shows a positive result) is relatively rare (approximately 0.01-2% of cases). If you suspect that the result of your test is incorrect, contact your gynecologist and consult with him what to do next (usually, in this case, the gynecologist will prescribe a repeat test or additional examinations).

False-negative results of a blood test for hCG (when a woman is pregnant, but the test shows a negative result) can occur if the rules for donating blood for analysis were violated, if the gestational age was incorrectly determined, you had late ovulation or late implantation (attachment of the fetus in uterus). In very rare cases of ectopic pregnancy, hCG blood test results may also be false negative. If you suspect that the hCG blood test was incorrect, consult your gynecologist.

Blood test for hCG in menopause (menopause)

In women who have already entered menopause (after menstruation has stopped), the level of hCG in the blood may be slightly elevated. Thus, some gynecologists consider it normal if, after the onset of menopause, the level of hCG in a woman’s blood reaches 14 mIU/ml (mIU/ml) (while in women before the onset of menopause, the hCG level normally does not exceed 5 mIU/ml (mIU/ ml)).

Blood test for progesterone to determine pregnancy

In some cases, in addition to determining the level of hCG in the blood, the doctor also recommends a blood test for progesterone. Progesterone is a pregnancy hormone, and its level can determine how successfully your pregnancy is developing.

Most doctors believe that a progesterone level above 25 ng/ml (or 79.5 nmol/l) in early pregnancy means the pregnancy is progressing well. If the level of progesterone during pregnancy is less than 5 ng/ml (or 15.9 nmol/l), then the chances of a successful pregnancy are quite low. Intermediate values ​​from 5 to 25 ng/ml (or from 15.9 nmol/l to 79.5 nmol/l) require repeated measurements after some time.

How does the hCG level change after a miscarriage (miscarriage or abortion)?

In the first few days and even weeks, the level of hCG in the blood may remain elevated. However, if the pregnancy is terminated, the hCG level will gradually decrease (but in no case increase). In most cases, hCG levels return to normal within 4 to 6 weeks after a miscarriage or abortion.

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It should be understood that these indicators are not absolute and accurate. The hCG level during pregnancy may deviate slightly from the norm, and this does not mean that there are any abnormalities or pathological changes in the fetus.

In most cases, doctors monitor the dynamics of hormone levels throughout the entire period of gestation.

How to prepare for research?

A blood test for the presence of hCG is carried out only in medical institutions. Only venous blood is needed. Beforehand, you should not eat or drink drinks 8-10 hours before. This is a prerequisite for passing any analysis. It is precisely because this condition is not met that many analyzes become incorrect. By the way, ordinary seeds or spicy adjika can provoke a positive result when donating blood for sexually transmitted diseases. In addition, when taking a test during pregnancy, you should not be sexually active and try not to overload your body with physical activity; these factors greatly influence the result and determination of pregnancy.

If before conducting the study, a person took medications for 2-3 months, this should be reported to the attending physician. For pregnant women, the test can be taken as early as the fourth week after conception, and to identify pathologies - two weeks after the first examination. If it is necessary to study diseases, blood is donated at intervals of 4-7 weeks, depending on what disease needs to be identified.

The study may also be erroneous when a person took medications that included human chorionic gonadotropin. These medications are taken mainly to stimulate ovulation. Treatment of infertility requires taking this hormone. No more medicine can affect the level and indicator of hCG in the blood. Many women ask whether taking contraceptives can affect the amount of the hormone in the blood. The answer is clear - no. Despite the fact that almost all birth control pills contain a small percentage of hormonal agents, other hormones will not be able to increase or decrease the level of human chorionic gonadotropin.

What does high and low hormone levels mean?

A low level of production of human chorionic gonadotropin can be interpreted as the presence of such abnormalities:

  • ectopic pregnancy (indicator will be below 0);
  • frozen fetus or its death;
  • physiological delay in embryo development;
  • risk of miscarriage;
  • pathological abnormalities in the structure of the placenta;
  • the presence of genomic pathology in the fetus.

Only an experienced doctor can decipher the hCG analysis during pregnancy. Again, do not forget that you should not eat food before donating blood. Only in this case can the level of the hormone in the blood be correctly deciphered.

In an ectopic pregnancy, the fertilized egg implants in the fallopian tubes or in the abdominal cavity. This means that the pregnancy cannot develop normally, and in some cases serious consequences and abnormalities occur. The interpretation and the result will show that the level of the hormone during an ectopic pregnancy is initially increased, but is not the same as during conception in the uterus, but 4 units less. But, by the fifth week, the amount of the hormone decreases sharply. One such study, of course, will not be able to determine an ectopic pregnancy; this requires the results of an ultrasound examination.

When the fetus dies, human chorionic gonadotropin levels drop sharply. In the early stages of pregnancy, the fetus undergoes a toxic process with fading.

When a woman is not planning a pregnancy and knows for sure that there was no fertilization process, but after taking tests for production, she receives a result that shows that the level of the hormone is increased, this can be an alarming sign.

Genomic pathology in the fetus scares many expectant mothers. Today, doctors conduct special examinations in order to identify the presence of this pathology as quickly as possible. For this purpose, screening is carried out in the 1st and 2nd trimester. The first trimester is decisive; if a woman has a high hormone level, then the fetus has obvious pathological abnormalities. But you don’t need to panic right away; you need to see a doctor who can interpret the hCG analysis. High levels of the hormone may mean that a pregnant woman has two or more fetuses. If toxicosis is too strong, its amount will also be increased.

In men, a high level of the hormone can mean diabetes or gestosis. In any case, it is impossible to determine from one study, because in some cases, when the hormone rises, it seems to warn that bleeding is possible. In order to correctly interpret and decipher the analysis, it is necessary to undergo several more types of examination and only then draw the appropriate conclusions.

Any tests are always repeated in order to eliminate the risk of error. HCG analysis during pregnancy is no exception. The result and decoding may also be erroneous. Erroneous analyzes fall into two categories:

  • false positive test result;
  • false - negative.

Although such results are rare, there is still a risk of erroneously detected hormone levels.

We can talk about false-positive results of blood tests for hCG if a woman is not fertilized, but the result showed the opposite. In this case, a repeat analysis is prescribed after 2.5 weeks. The reasons for such a blood test for hCG may be:

  • violation of the rules for donating or collecting blood;
  • incorrect deadline;
  • ovulation disorder in a woman;
  • untimely attachment of the embryo.

The level of the hormone in a woman’s blood can change after a premature termination of pregnancy and after a spontaneous miscarriage has occurred. 7 weeks after the pregnancy is terminated, naturally or forcibly, the hormonal level will return to normal. If it increases, it will be necessary to undergo additional examinations; repeated interpretation will help determine the reason for the increase in the level of the hormone in the body. In some cases, after an incorrectly performed operation, accumulations may remain in the uterine cavity; the level of the hormone will also be increased in this case and will decrease only when a repeat operation is performed.

In some women, human chorionic gonadotropin levels may be high when menopause begins (menopause). The decoding will show that the hormone level in a woman who has not reached menopause (under 50 years old) is 4, during menopause it rises to 15. In such cases, doctors prescribe medications to women that can regulate the hormone level.

Carrying a baby is an exciting and very responsible period. Now a young mother must be registered with a doctor and undergo all the necessary tests. There is hardly a woman who, during pregnancy, would not be prescribed a blood test for human chorionic gonadotropin. In the article we will figure out what this substance is, and also find out when a blood test for hCG will show pregnancy.

Human chorionic gonadotropin is a unique hormone synthesized by chorion tissue almost immediately after the fertilized egg attaches to the uterine wall. This happens a week after the sperm meets the egg. From the first days after fertilization, the amount of hCG begins to increase rapidly and only by 11-12 weeks its growth stops.


Many modern pregnancy tests are based on the quantitative and qualitative composition of hCG beta subunits in urine. If pregnancy has already occurred, then a decrease in the level of this hormone may indicate various pathologies, for example, a threat of miscarriage, or fetal fading.

Properties of human chorionic gonadotropin

As we have already found out, the production of human chorionic gonadotropin begins in the first days after implantation of the embryo. HCG can be detected in the blood of a pregnant woman 9-10 days after ovulation. Usually this period coincides with the process of implantation of the fertilized egg into the uterine wall.

The main role of hCG during pregnancy is to maintain the functioning of the corpus luteum of the ovary.

This function of the hormone is made possible due to the unique structure of hCG. The human body contains LH (luteinizing hormone), FSH (follicle stimulating hormone) and thyroid-stimulating hormone. They consist of two subunits (alpha and beta). HCG has a similar structure. All of these substances have an identical alpha unit, but differ only in the beta unit. It is the latter that determines some additional functions of hormones and their stability.


Ovulation in the female body occurs due to LH and FSH. After this process is completed, the follicle transforms into the corpus luteum. Constant releases of luteinizing hormone keep it functioning. But due to the fact that the corpus luteum lives only for a few hours, its other, constant stimulation is necessary. If fertilization does not occur, the corpus luteum dies. In case of fertilization, the production of hCG begins. It is this hormone that maintains the constant functioning of the corpus luteum, because human chorionic gonadotropin acts in the same way as LH.

The decomposition period of human chorionic gonadotropin is longer than that of luteinizing hormone.

Thanks to these properties of hCG, the corpus luteum is constantly stimulated, which allows pregnancy to develop normally. Progesterone will be produced until the very moment the placenta begins to function.

Many people believe that hCG is necessary solely to maintain the functioning of the corpus luteum. Actually this is not true. The significance of this hormone is also as follows:

  • stimulation of the growth of blood vessels in the uterus;
  • repulsion of immunoglobulins from the embryo;
  • protection of the implanted fertilized egg from destruction as a foreign body;
  • stimulation of the fetal testis, which ensures normal development of the genital organs in boys;
  • ensuring the process of lowering the testicles into the scrotum area.

It is interesting to know that in representatives of the stronger sex, hCG is also produced in the body in small quantities. Usually its concentration does not exceed 5 mIU/ml.


The function of human chorionic gonadotropin in men is to maintain the normal process of testosterone production. Of course, luteinizing hormone also copes well with this task, and hCG is its additional support.

Why is a hCG test prescribed during pregnancy?

The first thing that a hCG test allows you to find out is whether pregnancy has occurred or not. Many women mistakenly believe that this is where the role of the hormone is limited. In fact, the role of gonadotropin is much broader. By assessing its concentration in the body, it is possible to find out whether the pregnancy is multiple. After all, each embryo produces a certain amount of hCG.

Blood donation for this indicator is usually prescribed during prenatal screenings at 12-15 and 16-20 weeks. This analysis makes it possible to timely identify certain chromosomal abnormalities in the fetus and suspect developmental defects.

An unscheduled blood test for hCG is prescribed if there is a suspicion of embryonic failure, fetal development retardation, ectopic pregnancy and some other pathologies. It is mandatory to donate blood for human chorionic gonadotropin among patients who have had an abortion or miscarriage.

Men and women donate blood for hCG if they suspect the presence of malignant tumors in the body.

After fertilization occurs, hCG in a woman’s body begins to be produced at a very high rate. Every day it doubles several thousand times. Immediately after the meeting of the egg and sperm, the fertilized egg needs approximately 6-8 days to reach the uterus and implant into its wall. From this we can conclude that pregnancy or its absence can be confirmed 9-10 days after the expected date of conception. This is almost a week earlier than the onset of conception can be diagnosed by conventional pharmacy tests.

In addition, it cannot be ignored that the sensitivity of pharmacy tests is 2-3 times lower than laboratory testing. In addition, the concentration of hCG in the urine increases more slowly than in the blood.


In a non-pregnant woman, the level of human chorionic gonadotropin is no more than 5 mU/ml. Immediately after the implantation of the fertilized egg into the uterine wall, the concentration of the hormone begins to increase and doubles in the first day, that is, up to 10 mU/ml. The next day - 20 mU/ml, then 40-60 mU/ml and so on. In urine, the concentration of hCG during this period will be half as much, that is, 30 mU/ml. The sensitivity threshold of pharmacy tests is usually from 15 mU/ml, therefore, during this period, a woman will be able to determine the onset of conception using the test.

Despite the convenience of this type of diagnosis, tests often give erroneous results. After all, they may be defective, past their expiration date. In addition, a woman may perform the diagnostic procedure itself incorrectly. A blood test in a laboratory is a more reliable research method. Errors are extremely rare here.

A blood test for hCG allows you not only to confirm or refute the fact of pregnancy, but also to find out the approximate date of birth and to suspect pathologies of fetal development.

Features of blood donation

In medical practice, it is customary to observe certain standards for blood sampling for hCG:

  • Conducting a study if the patient has a delay in menstruation for more than three days or 10-12 days after the date of expected fertilization. It is at this time that laboratory research will have the most accurate results.
  • Taking a blood test after a medical termination of pregnancy. Experts prescribe the woman to undergo this test on the second and fifth days after the abortion, which helps ensure the success of the procedure.
  • Blood testing for hCG allows you to determine the onset of conception, the duration of pregnancy, and the success of its development. In this case, the analysis is carried out several times over time in order to track the dynamics of embryo development.
  • The method allows you to suspect and identify malformations in the fetus and the presence of certain chromosomal diseases (Down syndrome, Edwards syndrome and other diseases).

It is important to note that during diagnosis, the first results of the analysis for human chorionic gonadotropin are not decisive. It is tracking these indicators over time that allows you to fully assess the development of pregnancy. We cannot ignore the fact that each woman’s hCG can fluctuate depending on some individual characteristics.


Blood is donated for hCG at least twice. During this procedure, a sample of human biological material is taken from a vein. In rare cases, laboratories use blood from a finger. This is explained by the fact that both venous and capillary blood act as one biological medium, therefore, both types of biological material contain human chorionic gonadotropin.

To obtain reliable results, a woman needs to know how to properly take an hCG test. In most cases, blood is drawn from a vein. This procedure is carried out in the morning. At the same time, it is undesirable to eat or drink anything. If it was not possible to donate blood in the morning, the procedure can be performed at other times of the day. The main thing is that after the last meal, at least 8 hours pass before submitting the biological material for research.

It is mandatory to inform the doctor about taking any medications the day before the diagnosis. Some drugs can lower or increase the concentration of hCG in a woman’s blood.

You can drink water in small quantities. It will not affect the hormone levels in the body. But you should definitely refrain from drinking strong tea, coffee, and even more alcohol. There is also no need to eat too fatty or protein foods. This can affect hormonal balance.

Blood can be donated for hCG at any antenatal clinic. Private clinics also provide the service, however, there this type of diagnosis can cost much more. Usually you have to wait up to 5 hours for results.


Commercial clinics often do not have their own laboratory. They are only intermediaries for sending results to larger centers. In this regard, the result of the study will have to wait longer.

Gonadotropin levels depending on the stage of pregnancy

An hCG test allows you to confirm the fact of conception and determine the timing of pregnancy. To obtain reliable data during diagnosis, the timing of the release of the egg from the ovary must be taken into account. For convenience, this period is denoted by the abbreviation DPO, that is, “day after ovulation.” Typically, such tests are carried out among women planning motherhood.

In the initial stages, the growth of human chorionic gonadotropin does not occur at such a rapid pace as, for example, at 6-7 weeks. In this case, the results of the study may look something like this: “12 DPO – 20 mIU/ml.”
All laboratories use an individual results table, which records data on the minimum, average and maximum hCG levels at a given time. The countdown starts from day 7 until day 42 of DPO.


If we take the average values, then at 7-8 DPO the minimum value will be no more than 2 mIU/ml, the average will be up to 5 mIU/ml, and the maximum will be up to 10 mIU/ml. In comparison, 42 DPO has a minimum of 28,000 mIU/ml, an average of 65,000 mIU/ml, and a maximum of 128,000 mIU/ml.

There are also certain tables that are used to compare results during pregnancies that have already taken place. Here, the beginning is taken from the moment of implantation of the embryo into the wall of the uterus (implantation of the fertilized egg or DPP) until 42 weeks. The table contains days of pregnancy and human chorionic gonadotropin concentrations.


It is important to note that in vitro fertilization (IVF) uses different tables. The days and indicators for embryos implanted 3 and 5 days after fertilization of the egg will be indicated here. Read more about hCG by week in.

Let us remind you that the interpretation of the results depends on the laboratory in which the woman was tested, and interpretation is performed exclusively by a specialist.

Decoding the received data

Having received the results of the study, the specialist compares these indicators with established standards. These indicators must be assessed over time. If the hCG level increases, this indicates normal development of the embryo. If, after an increase, human chorionic gonadotropin begins to fall, we are talking about various pathologies, such as fading or termination of pregnancy. Based on the amount of hCG in the blood, a single or multiple pregnancy can be diagnosed.

Two or more embryos often develop after IVF. In this case, the concentration of the hormone in the blood will be several times higher. In addition, hCG determines the presence of developmental pathologies in the fetus. In addition to hCG, the woman is recommended to undergo additional medical examinations. These include ultrasound, chorionic villus testing, umbilical cord blood analysis and others.

In the second trimester, a triple analysis helps to assess the successful development of pregnancy, including a blood test for hCG, ACE and estradiol.


ACE stands for alpha fetoprotein. This substance acts as an oncological marker in the human body. If the level of ACE and estradiol is within the normal range, and hCG is significantly deviated, there is every reason to suspect that the child has Down syndrome. You can read more about this disease.

If all three indicators are low, the chromosomal disease Edwards syndrome or Patau syndrome is suspected. Additional medical diagnostic techniques help confirm or refute these suspicions.

Suspicion of Turner syndrome is caused by a decrease in the levels of ACE and estradiol with normal hCG levels.

If the doctor suspects the presence of a genetic pathology in a child, do not panic ahead of time. Forecasts are often wrong.

Can the results be wrong?

A blood test for hCG is considered one of the most accurate and reliable methods. It is for this reason that this research method has found such wide application in medical practice for more than one decade. Despite this, you cannot insure yourself against mistakes. Therefore, let's look at why false positive and false negative results can occur.

False positive response

Sometimes the analysis shows a high level of hCG in a woman’s body, but pregnancy is not diagnosed. Why is this happening:

  • An increase in the concentration of human chorionic gonadotropin in a woman can occur in situations where the patient was previously taking hormonal drugs.
  • A high level of hCG is found in tumor formations in the body.
  • An increase in the level of the hormone is often diagnosed with hormonal disorders in the body due to diseases of the thyroid gland.

In any case, if suspicious test results occur, it is recommended to retake the test after a few days.

Sometimes it happens that pregnancy has occurred, but the hCG test shows a negative result. This happens because pregnancy is diagnosed too early, when the fertilized egg has not yet attached to the uterine wall and the production of human chorionic gonadotropin has not yet begun.


Negative or very low levels of hCG are often found in ectopic pregnancies. To confirm this diagnosis, it is necessary to conduct a repeated examination every two days, as well as use ultrasound.

What indicators should be normal?

Only a qualified doctor can judge to what extent certain results of blood sampling for the level of human chorionic gonadotropin correspond to the norm. Factors such as the woman’s age, the presence of chronic diseases, multiple or single pregnancy, and so on must be taken into account.

For convenience, doctors use special tables that help compare the data obtained with the upper and lower limits of acceptable standards. In addition, such tables help to accurately determine the duration of a developing pregnancy.

It is known that it is almost impossible to accurately determine the date of fertilization of the egg. In this regard, doctors count conception from the first day of the last menstruation. These are obstetric weeks, which are counted from the moment the mature egg leaves the ovary.

Unlike embryonic, obstetric timing is imprecise and can be off by 1-2 weeks. The true period after conception, that is, embryonic, is always 7-14 days less than the obstetric period. This depends on the length of the woman's menstrual cycle.

An hCG test helps to find out with high certainty the exact period after conception. After all, we know that human chorionic gonadotropin begins to be synthesized in the body from the first hours after embryo implantation. By assessing hCG in the blood, you can find out the time of conception. Ultrasound helps confirm these data.


In this table you can find the upper and lower limits of hCG for a given week of pregnancy.

Advantages of blood tests over pharmacy tests

A woman can find out whether pregnancy has occurred using a regular test, which can be purchased at a pharmacy. These tests contain certain reagents that react with hCG. If conception has occurred, the test will show two stripes. This diagnostic method is very convenient because it can be done at home.

The disadvantage of tests before laboratory testing is that they can only detect the presence of pregnancy. It is impossible to determine the place of attachment of the egg and the correct development of the embryo. In addition, a blood test can detect the onset of conception earlier than a conventional test.


Carrying out a blood test for human chorionic gonadotropin over time also helps to suspect the presence of chromosomal abnormalities in a child and promptly recognize the threat of miscarriage, ectopic pregnancy and fetal death. The test will not be able to provide such information.

Types of analysis for hCG

In medical practice, several types of blood tests for human chorionic gonadotropin are used. This is a general analysis for hCG and the detection of free beta-hCG in the body. Let's take a closer look at them.

General

This type of diagnostic technique is used to determine the occurrence of egg fertilization in the early stages, when conventional tests are not yet able to determine conception. In the second trimester, a test for total human chorionic gonadotropin is prescribed in the form of a triple test, which was described earlier in the article.

Free beta-hCG

This type of examination is used for hydatidiform mole, choriocarcinoma, testicular oncology and suspected other pathologies in the fetus. In the first and second trimester, this test is used to assess the baby's risk of Edwards and Down syndrome.
If there are deviations from the norm, the woman is placed at risk and referred for additional studies.

Will the test show pregnancy before a missed period and when is the best time to donate blood?

Many girls are interested in the question of how long the fertilization field must pass in order to determine the onset of pregnancy before the delay? The most reliable method of detecting conception before a missed period is a laboratory blood test for hCG. It is recommended to do it 7-9 days after the expected date of conception.

During this period, active production of human chorionic gonadotropin begins. If the study showed a hormone concentration of more than 7 mIU/ml, there is reason to suspect pregnancy. When the study is repeated and the pregnancy progresses successfully, the hCG level increases several times every day.

It is recommended to donate blood for human chorionic gonadotropin 7-10 days after trying to conceive.

Reason for donating blood

Many women are planning pregnancy. This is the right decision, because such an important issue should be taken seriously. The reason for getting tested is undoubtedly a delay in menstruation. Women whose cycles are irregular can donate blood even before the delay, because it often happens that pregnancy is diagnosed even before menstruation begins. Be that as it may, donating blood immediately after unprotected sex does not make sense. To get an accurate result, it is better to wait a few weeks.

Low levels of human chorionic gonadotropin are an undesirable phenomenon exclusively for a woman expecting a baby. In other situations, this hormone should not exceed 5 mIU/ml. If in a man or a non-pregnant girl these levels exceed 5-10 mIU/ml, you should definitely look for the cause. The fact is that hCG acts as a tumor marker and indicates the presence of an oncological process in the body.


Causes of elevated hormone levels:

  • benign or malignant formations in the testicles or uterus;
  • oncology in the gastrointestinal tract, kidneys, liver;
  • formations in the respiratory system.

If the hormone level constantly increases over time, this indicates the process of cancer cells spreading to organs located near the diseased area. Sometimes human chorionic gonadotropin increases when treated with certain medications.

Conclusion

Every woman should remember that the interpretation of the results obtained during the study should be carried out exclusively by the doctor. If the hormone is elevated, this does not always mean pregnancy. Under no circumstances should you make your own diagnosis or self-medicate. This can lead to extremely serious consequences.

Video

This video will help you learn more about hCG during pregnancy.

Actually, ovulation normally occurs 2 weeks after menstruation. Therefore, it is best to count at least seven days after intercourse and only then go to the laboratory.

What kind of test is this

The previously mentioned hormone is always present in the female body in extremely small quantities. The standard value is from 0 to 15 mIU/ml. This level indicates that conception has not occurred.

When fertilization of the egg occurs already in the 1st DPO, hCG begins to be intensively produced. In general, the hormonal background of an expectant mother changes rapidly in just a few hours. However, at first, the numerical changes are minimal, so donating blood during this period is pointless.

Gradually increasing, the hCG content ensures the normal development of the embryo. As is known, this protein is produced directly in the embryonic membrane. Thus, the larger the baby, the greater the content of human chorionic gonadotropin.

Many people are interested in whether it is possible to determine the exact date of pregnancy using blood? This in reality does not pose any problem. Any competent specialist processing tests in the laboratory will tell you the date.

Why is a hCG test prescribed? There are many reasons:

  • early detection of pregnancy;
  • intermediate monitoring of the condition of both the baby and the mother throughout the entire period of gestation;
  • with amenorrhea (absence of menstruation);
  • miscarriage risk analysis;
  • differentiation of ectopic pregnancy;
  • determining the effectiveness of abortion;
  • diagnosing cancer (including men).

When to go for analysis

As evidenced by expert reviews, the analysis in question will show pregnancy using hCG even before the delay begins. Different laboratories have their own recommendations regarding the most optimal time to visit a doctor.

If you can’t wait to find out if there will be a baby, donate blood in 6 or 7 days. But for the most part, as doctors indicate, it is better not to rush and postpone the visit for two weeks. So, to avoid errors, the analysis is repeated after 2 or 3 days.


In a situation where we are talking about an IVF procedure, the test is not carried out immediately, but at least 12 days after the final injection. It is important to understand that in this situation not all standard indicators are applicable, since the hormonal background of a woman who decides to undergo in vitro fertilization often differs significantly from normal.

Analysis results

The level of hCG in the blood is measured in international units (mIU) per milliliter. Some laboratories use the English abbreviation mIU/ml. The designation in nanograms (ng/ml) is practically no longer found. To recalculate the result, it is simply multiplied by 21.28.

If, after taking the test, you were found to have the amount of the hormone in question in the range from 0 to 5 mIU, then this means that everything is in order with your health and you are not pregnant.

At the same time, a small increase (from 5 to 25) is considered as an inaccurate or questionable result. In such a situation, the doctor will probably advise you to re-donate blood in 3-4 days. It is important to go to the same laboratory where you went before. If conception is successful, then over the specified period the volume of hCG will definitely increase. If the level remains unchanged, the doctor will suspect the onset of a disease or the development of a neoplasm.

You will definitely become a mommy if you end up with a value above 25 mIU/ml. However, the gynecologist will most likely give a referral for a repeat examination for final confirmation.

Tests during pregnancy


As the fetus develops, hCG levels will continue to rise. In the first few decades of pregnancy, the normal hormone level ranges from 50 to 300 international units. During this period, almost all women gain a little weight (the average norm is half a kilogram).

By the end of the 4th week, human chorionic gonadotropin becomes many times greater. The indicator here is from 1.5 thousand to 5. Then, by the third month, hCG rises to 30,000.

During the second trimester, the amount of the hormone will reach 60 thousand international units.

Triple analysis

This test allows you to identify existing developmental disorders in your child based on three indicators. The content of the following substances is taken into account:

  • hCG itself;
  • estriol;
  • alpha-fetoprotein.

An increased level of human chorionic gonadotropin against the background of a decrease in the amount of other components indicates Down syndrome.

Excess alpha-fetoprotein, when other indicators remain within standard limits, indicates a disorder in the development of the neural tube.

When all three substances are present in large quantities, the mother bears several children.

According to doctors, the accuracy of this analysis is very high – approximately 95 percent. However, in recent years, many critics have appeared who claim that the coincidence of forecasts with the real picture is observed in only 20 pregnant women out of a hundred.